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Isolated Systolic Hypertension in the Young
2019
Elevated systolic blood pressure with normal diastolic blood pressure is the most prevalent type of hypertension in young people. The prevalence of isolated systolic hypertension reported among youth ranges widely as a result of the differences in population characteristics such as age, ethnicity, and obesity. Even though it is not an unusual condition, there is still debate in the literature about the clinical significance of an isolated increase in systolic blood pressure detected in the first decades of life. The reported phenotypic characteristics of subjects with isolated systolic hypertension are rather scarce and many relevant pieces of information are still elusive. Further studies …
Concentration and energy fluctuations in a critical polymer mixture
1995
A semi-grand-canonical Monte Carlo algorithm is employed in conjunction with the bond fluctuation model to investigate the critical properties of an asymmetric binary (AB) polymer mixture. By applying the equal peak-weight criterion to the concentration distribution, the coexistence curve separating the A-rich and B-rich phases is identified as a function of temperature and chemical potential. To locate the critical point of the model, the cumulant intersection method is used. The accuracy of this approach for determining the critical parameters of fluids is assessed. Attention is then focused on the joint distribution function of the critical concentration and energy, which is analysed usi…
Phase separation of symmetrical polymer mixtures in thin-film geometry
1995
Monte Carlo simulations of the bond fluctuation model of symmetrical polymer blends confined between two “neutral” repulsive walls are presented for chain lengthNA=NB=32 and a wide range of film thicknessD (fromD=8 toD=48 in units of the lattice spacing). The critical temperaturesTc(D) of unmixing are located by finite-size scaling methods, and it is shown that\(T_c (\infty ) - T_c (D) \propto D^{ - {1 \mathord{\left/ {\vphantom {1 {v_3 }}} \right. \kern-\nulldelimiterspace} {v_3 }}} \), wherev3≈0.63 is the correlation length exponent of the three-dimensional Ising model universality class. Contrary to this result, it is argued that the critical behavior of the films is ruled by two-dimensi…
Array CGH defined interstitial deletion on chromosome 14: a new case
2009
Interstitial deletions of the long arm of chromosome 14 are relatively rare. We report a 8.5-year-old girl with dysmorphic facial features and mental retardation associated with a de novo interstitial deletion of chromosome 14. The comparison between our patient and all published patients is reviewed. The genetic investigations have allowed us to define the critical chromosomal region and to start an accurate follow-up.
Monitoring barley and corn growth from remote sensing data at field scale
2004
Vegetation indices have been used for operational quantitative monitoring of vegetation. Here, corn and barley cultures have been used to relate meaningful biophysical parameters such as dry biomass and Crop Growth Rate (CGR) to the well-established Normalized Difference Vegetation Index (NDVI). We explain these relationships by means of the use of the Light Use Efficiency (LUE) models, based on the positive relation between primary production and Absorbed Photosynthetically Active Radiation (APAR). In these models we introduce NDVI as a linear estimator of f APAR. Experimental data over corn and barley show that dry biomass is linearly related to the Time-Integrated Value of the NDVI (TIND…
Global Scale IB AMSR2 Vegetation Optical Depth at X-Band
2021
Vegetation Optical Depth (VOD) plays an increasingly important role in studying global carbon, water and energy transformation [1], [2]. This study explores the performance of the X-MEB (X-band microwave emission of the biosphere) model at global scale. Similar to the L-MEB model, the X-MEB model, built by INRAE (Institut national de recherche pour l'agriculture, l'alimentation et l'environnement) Bordeaux, aims to retrieve VOD (referred to as IB X-VOD) at X-band. To avoid the ill-posed problem caused by retrieving two parameters of interest (soil moisture (SM) and VOD) from mono-angular and dual-polarized observations (AMSR2), which are strongly correlated, we used the ERA5 SM product as a…
Duration of untreated psychosis in first-episode psychosis is not associated with common genetic variants for major psychiatric conditions: results f…
2021
The EU-GEI Project is funded by the European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010–241909 (Project EU-GEI).
Small omphalocele with umbilical evagination of the bladder: a distinct entity?
2006
A neonatal case of umbilical evagination of the bladder combined with a small omphalocele is presented. This rare congenital malformation has previously been described in only three cases. Umbilical evagination can be understood as a disturbance of development of both the vitelline and allantoic ducts, resulting in a non-descended but otherwise normal bladder opening to the inferior margin of a small omphalocele. Diagnosis is made by clinical inspection and ultrasound. Since other malformations are not present, this entity may be regarded as a minor form of a lower midline defect with excellent prognosis.
Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification.
2015
Mechanisms of initial cell fate decisions differ among species. To gain insights into lineage allocation in humans, we derived ten human embryonic stem cell lines (designated UCSFB1-10) from single blastomeres of four 8-cell embryos and one 12-cell embryo from a single couple. Compared with numerous conventional lines from blastocysts, they had unique gene expression and DNA methylation patterns that were, in part, indicative of trophoblast competence. At a transcriptional level, UCSFB lines from different embryos were often more closely related than those from the same embryo. As predicted by the transcriptomic data, immunolocalization of EOMES, T brachyury, GDF15 and active β-catenin reve…
Postnatal overfeeding in rats leads to moderate overweight and to cardiometabolic and oxidative alterations in adulthood.
2011
In contrast to the masses of data on obesity, few data are available concerning the cardiometabolic and oxidative consequences of moderate overweight. The model of postnatal overfeeding (OF) induces an increase in body weight at weaning that remains during adult life. Litters of Wistar rats were either maintained at 12 pups (normal-fed group, NF), or reduced to 3 pups at birth in order to induce OF. At 6 months of age, metabolic parameters, circulating oxidative stress and aortic and coronary vasoreactivity were assessed. Cardiac susceptibility to ischemia-reperfusion injury was also evaluated ex vivo as were markers of cardiac remodeling. OF led to an increase in body weight at weaning (+5…