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showing 10 items of 2571 documents
Identification of ELF3 as an early transcriptional regulator of human urothelium
2014
AbstractDespite major advances in high-throughput and computational modelling techniques, understanding of the mechanisms regulating tissue specification and differentiation in higher eukaryotes, particularly man, remains limited. Microarray technology has been explored exhaustively in recent years and several standard approaches have been established to analyse the resultant datasets on a genome-wide scale. Gene expression time series offer a valuable opportunity to define temporal hierarchies and gain insight into the regulatory relationships of biological processes. However, unless datasets are exactly synchronous, time points cannot be compared directly.Here we present a data-driven ana…
Testing for goodness rather than lack of fit of an X–chromosomal SNP to the Hardy-Weinberg model
2019
The problem of checking the genotype distribution obtained for some diallelic marker for compatibility with the Hardy-Weinberg equilibrium (HWE) condition arises also for loci on the X chromosome. The possible genotypes depend on the sex of the individual in this case: for females, the genotype distribution is trinomial, as in the case of an autosomal locus, whereas a binomial proportion is observed for males. Like in genetic association studies with autosomal SNPs, interest is typically in establishing approximate compatibility of the observed genotype frequencies with HWE. This requires to replace traditional methods tailored for detecting lack of fit to the model with an equivalence test…
Higgs mass predicted from the standard model with asymptotically safe gravity
2016
Tässä Pro Gradu -tutkielmassa tavoitteena on ennustaa Higgsin bosonin massa ottaen lähtökohdaksi hiukkasfysiikan standardimalli, johon on kytketty gravitaatio ns. asymptoottisesti turvallisena teoriana. Ennusteen laskemiseksi selvitetään Higgsin bosonin itseiskytkennän ja neljän muun standardimallin kytkinvakion juokseminen, eli kytkinvakioiden käyttäytyminen energiaskaalan funktiona, johtavassa kertaluvussa MS-skeemassa. Standardimallista saatuihin β-funktioihin lisätään asymptoottisesti turvallisen gravitaation antamat korjaukset suurilla energiaskaaloilla, jonka jälkeen β-funktioiden muodostama differentiaaliyhtälöryhmä ratkaistaan numeerisesti. Standardimallin osittainen äärellinen remo…
To d , or not to d : recent developments and comparisons of regularization schemes
2017
We give an introduction to several regularization schemes that deal with ultraviolet and infrared singularities appearing in higher-order computations in quantum field theories. Comparing the computation of simple quantities in the various schemes, we point out similarities and differences between them.
Weight Systems from Feynman Diagrams
1996
We find that the overall UV divergences of a renormalizable field theory with trivalent vertices fulfil a four-term relation. They thus come close to establish a weight system. This provides a first explanation of the recent successful association of renormalization theory with knot theory.
Entropy Production during Asymptotically Safe Inflation
2011
The Asymptotic Safety scenario predicts that the deep ultraviolet of Quantum Einstein Gravity is governed by a nontrivial renormalization group fixed point. Analyzing its implications for cosmology using renormalization group improved Einstein equations we find that it can give rise to a phase of inflationary expansion in the early Universe. Inflation is a pure quantum effect here and requires no inflaton field. It is driven by the cosmological constant and ends automatically when the renormalization group evolution has reduced the vacuum energy to the level of the matter energy density. The quantum gravity effects also provide a natural mechanism for the generation of entropy. It could eas…
From Big Bang to Asymptotic de Sitter: Complete Cosmologies in a Quantum Gravity Framework
2005
Using the Einstein-Hilbert approximation of asymptotically safe quantum gravity we present a consistent renormalization group based framework for the inclusion of quantum gravitational effects into the cosmological field equations. Relating the renormalization group scale to cosmological time via a dynamical cutoff identification this framework applies to all stages of the cosmological evolution. The very early universe is found to contain a period of ``oscillatory inflation'' with an infinite sequence of time intervals during which the expansion alternates between acceleration and deceleration. For asymptotically late times we identify a mechanism which prevents the universe from leaving t…
Pair creation in electric fields, anomalies, and renormalization of the electric current
2018
We investigate the Schwinger pair production phenomena in spatially homogeneous strong electric fields. We first consider scalar QED in four-dimensions and discuss the potential ambiguity in the adiabatic order assignment for the electromagnetic potential required to fix the renormalization subtractions. We argue that this ambiguity can be solved by invoking the conformal anomaly when both electric and gravitational backgrounds are present. We also extend the adiabatic regularization method for spinor QED in two-dimensions and find consistency with the chiral anomaly. We focus on the issue of the renormalization of the electric current $\langle j^\mu \rangle$ generated by the created pairs.…
The 1-loop effective potential for the Standard Model in curved spacetime
2018
The renormalisation group improved Standard Model effective potential in an arbitrary curved spacetime is computed to one loop order in perturbation theory. The loop corrections are computed in the ultraviolet limit, which makes them independent of the choice of the vacuum state and allows the derivation of the complete set of $\beta$-functions. The potential depends on the spacetime curvature through the direct non-minimal Higgs-curvature coupling, curvature contributions to the loop diagrams, and through the curvature dependence of the renormalisation scale. Together, these lead to significant curvature dependence, which needs to be taken into account in cosmological applications, which i…
Do we Observe Quantum Gravity Effects at Galactic Scales?
2005
The nonperturbative renormalization group flow of Quantum Einstein Gravity (QEG) is reviewed. It is argued that there could be strong renormalization effects at large distances, in particular a scale dependent Newton constant, which mimic the presence of dark matter at galactic and cosmological scales.