Search results for "Normetanephrine"

showing 3 items of 3 documents

Blood pressure changes after automatic and fixed CPAP in obstructive sleep apnea. Relationship with nocturnal sympathetic activity.

2011

Treatment of obstructive sleep apnea (OSA) by continuous positive airway pressure (CPAP) usually causes a reduction in blood pressure (BP), but several factors may interfere with its effects. In addition, although a high sympathetic activity is considered a major contributor to increased BP in OSA, a relationship between changes in BP and in sympathetic nervous system activity after OSA treatment is uncertain. This study was undertaken to assess if, in OSA subjects under no pharmacologic treatment, treatment by CPAP applied at variable levels by an automatic device (APAP) may be followed by a BP reduction, and if that treatment is associated with parallel changes in BP and catecholamine exc…

AdultMaleSympathetic nervous systemSympathetic Nervous SystemAmbulatory blood pressurePhysiologymedicine.medical_treatmentambulatory blood pressure monitoring catecholaminesBlood PressureSettore MED/10 - Malattie Dell'Apparato RespiratorioNorepinephrineCatecholaminesInternal MedicinemedicineHumansContinuous positive airway pressureWakefulnessSleep Apnea ObstructiveContinuous Positive Airway Pressurebusiness.industrySleep apneaGeneral MedicineBlood Pressure Monitoring AmbulatoryMiddle Agedmedicine.diseaseCircadian RhythmNormetanephrinenervous system diseasesrespiratory tract diseasesObstructive sleep apneamedicine.anatomical_structureBlood pressureAnesthesiaAmbulatoryCatecholamineSleepbusinessmedicine.drug
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Radioimmunoassay of Plasma and Urinary Norepinephrine

1989

Various analytical methods, such as fluorimetry, radioenzymic assay and in particular liquid chromatography are used for the analysis of norepinephrine (NA) in body fluids and tissue homogenates. These procedures, however, often lack sensitivity, are expensive and/or time consuming. Basing on our previous reports on the radioimmunoassay of chemically modified serotonin1, 5-hydroxy-3-indole acetic acid2 and normetanephrine (NMN)3, a sensitive radioimmunoassay of the N-acetyl,3-methoxy analogue of urinary and plasma norepinephrine was developed.

Norepinephrine (medication)chemistry.chemical_compoundChromatographyPlasma norepinephrineChemistryUrinary systemmedicineRadioimmunoassayNormetanephrinemedicine.drug
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Colorimetric detection of normetanephrine, a pheochromocytoma biomarker, using bifunctionalised gold nanoparticles.

2019

[EN] A simple and effective colorimetric method for the detection of normetanephrine (NMN), an O-methylated metabolite of norepinephrine, using functionalised gold nanoparticles is described. This metabolite is an important biomarker in the diagnosis of adrenal tumours such as pheocromocytoma or paraganglioma. The colorimetric probe consists of spherical gold nanoparticles (AuNPs) functionalised with two different ligands, which specifically recognize different functional groups in normetanephrine. Thus, a benzaldehyde-terminated ligand was used for the recognition of the amino alcohol moiety in NMN, by forming the corresponding oxazolidine. On the other hand, N-acetyl-cysteine was chosen f…

OxazolidineMetaboliteAdrenal Gland NeoplasmsMetal Nanoparticles02 engineering and technologyPheochromocytomaNormetanephrine01 natural sciencesBiochemistryAnalytical ChemistryAggregationchemistry.chemical_compoundQUIMICA ORGANICAMolecular recognitionLimit of DetectionCell Line TumorBiomarkers TumorGold nanoparticlesEnvironmental ChemistryHumansSpectroscopychemistry.chemical_classificationChromatographyBiomoleculeQUIMICA INORGANICA010401 analytical chemistryHomovanillic acid021001 nanoscience & nanotechnology0104 chemical sciencesNormetanephrinechemistryColloidal goldColorimetryNaked eyeGold0210 nano-technologyColorimetric detectionAnalytica chimica acta
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