Search results for "Note"

Antibacterial PEGylated Solid Lipid Microparticles for Cosmeceutical Purpose: Formulation, Characterization, and Efficacy Evaluation

2020

The development of efficacious means of delivering antioxidant polyphenols from natural sources for the treatment of skin diseases is of great interest for many cosmetic and pharmaceutical companies. Resveratrol (RSV) and Limonene (LIM) have been shown to possess good anti-inflammatory and antibacterial properties against Staphylococcus aureus infections responsible for many skin disorders, such as acne vulgaris. In this study, solid lipid microparticles are designed as composite vehicles capable of encapsulating a high amount of trans-RSV and enhancing its absorption through the stratum corneum. A microparticulate system based on mixture of PEGylate lipids, long-chain alcohols and LIM is a…

Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001-2011).

2013

Apaļā jūrasgrunduļa Neogobius melanostomus populācijas bioloģisko parametru raksturojums Latvijas piekrastē

2019

Darbā tika analizētas apaļā jūrasgrunduļa bioloģisko parametru izmaiņas Latvijas piekrastē, balstoties uz komerciālās un rūpnieciskās zvejas datu analīzi laika posmā no 2014. – 2018. gadam. Baltijas jūras atklātajā daļā dzīvojošie apaļie jūrasgrunduļi sasniedz lielāku ķermeņa izmēru, nekā Rīgas jūras līcī dzīvojošie īpatņi, izaugot aptuveni par 2 cm garāki. Taču pēdējo gadu laikā abos reģionos ir samazinājies īpatņu vidējais garums, ka arī mazāko īpatņu masa. Papildus analizējot vecumstruktūru un dzimumstruktūru izmaiņas Baltijas jūras atklātajā daļā novērojams tēviņu īpatsvara pieaugums, kā arī populācijas novecošanās, vidējam vecumam sasniedzot 3,6 gadus. Tika konstatēti arī samērā svārst…

Monoterpene derivatives from the flowers of Ferulago campestris, (Apiaceae).

2013

Ferulago campestris (Besser) Grec., (Ferula galbanifera (Mill) Kock. = F. campestris), finocchiazzo, is an annual or perennial herb of the Mediterranean area. In this paper the phytochemical studies of the CH2Cl2 and MeOH extracts of the flowers are described. Several ferulol derivatives and a new 10-hydroxy-verbenone ester (7) were isolated. The structure of the new compound was established by extensive NMR analysis, including HMBC and HSQC pulse sequences.

Chemical Composition of Essential Oils from Athamanta sicula

2008

The genus Athamanta L. (Apiaceae) consists of about nine species, which are distributed mainly in southeastern Europe. Some of the Athamanta species are used in traditional medicine as antiseptics, diuretics, and in the therapy of sclerosis [1]. Phytochemical studies of species from the genus Athamanta report the presence of coumarins [2–5], flavonoids [6], and fatty acids [7]. Athamanta sicula L. is an annual perennial herb, growing to a height of 30 to 100 cm. It occurs in calcareous vertical cliffs 100 meters to 1500 meters above sea level and is widespread in South Italy, particularly in Sicily. In the popular medicine, it is known as “spaccapietre” (rock splitters), and infusions of it…

Uptake mechanism of ApoE-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model.

2012

Background The blood-brain barrier (BBB) represents an insurmountable obstacle for most drugs thus obstructing an effective treatment of many brain diseases. One solution for overcoming this barrier is a transport by binding of these drugs to surface-modified nanoparticles. Especially apolipoprotein E (ApoE) appears to play a major role in the nanoparticle-mediated drug transport across the BBB. However, at present the underlying mechanism is incompletely understood. Methodology/Principal Findings In this study, the uptake of the ApoE-modified nanoparticles into the brain capillary endothelial cells was investigated to differentiate between active and passive uptake mechanism by flow cytome…

A class of shear deformable isotropic elastic plates with parametrically variable warping shapes

2017

A homogeneous shear deformable isotropic elastic plate model is addressed in which the normal transverse fibers are allowed to rotate and to warp in a physically consistent manner specified by a fixed value of a real non-negative warping parameter ω. On letting ω vary continuously (at fixed load and boundary conditions), a continuous family of shear deformable plates Pω is generated, which spans from the Kirchhoff plate at the lower limit ω=0, to the Mindlin plate at the upper limit ω=∞; for ω=2, Pω identifies with the third-order Reddy plate. The boundary-value problem for the generic plate Pω is addressed in the case of quasi-static loads, for which a principle of minimum total potential …

Investigating the Impact of Radiation-Induced Soft Errors on the Reliability of Approximate Computing Systems

2020

International audience; Approximate Computing (AxC) is a well-known paradigm able to reduce the computational and power overheads of a multitude of applications, at the cost of a decreased accuracy. Convolutional Neural Networks (CNNs) have proven to be particularly suited for AxC because of their inherent resilience to errors. However, the implementation of AxC techniques may affect the intrinsic resilience of the application to errors induced by Single Events in a harsh environment. This work introduces an experimental study of the impact of neutron irradiation on approximate computing techniques applied on the data representation of a CNN.

Functional Fibronectin Adsorption on Aptamer-Doped Chitosan Modulates Cell Morphology by Integrin-Mediated Pathway.

2019

A decisive step in cell-biomaterial interaction is represented by the adsorption of proteins at the interface, whose fine control may be useful to trigger proper cell response. To this purpose, we can selectively control protein adsorption on biomaterials by means of aptamers. Aptamers selected to recognize fibronectin dramatically enhance chitosan ability to promote cell proliferation and adhesion, but the underlying biological mechanism remains unknown. We supposed that aptamers contributed to ameliorate the adsorption of fibronectin in an advantageous geometrical conformation for cells, thus regulating their morphology by the proper activation of the integrin-mediated pathway. We investi…

Insight into the Mechanism of Action of Marine Cytotoxic Thiazinoquinones

2017

The electrochemical response of four natural cytotoxic thiazinoquinones isolated from the Aplidium species was studied using conventional solution-phase and solid-state techniques, based on the voltammetry of immobilized particles methodology. The interaction with O-2 and electrochemically generated reactive oxygen species (ROS) was electrochemically monitored. At the same time, a molecular modeling study including density functional theory (DFT) calculations was performed in order to analyze the conformational and electronic properties of the natural thiazinoquinones, as well as those of their reduced intermediates. The obtained electrochemical and computational results were analyzed and c…