Search results for "Note"
showing 10 items of 10709 documents
Inhalation solutions: which one are allowed to be mixed? Physico-chemical compatibility of drug solutions in nebulizers.
2006
AbstractTherapy of chronic respiratory diseases often involves inhalation therapy with nebulizers. Patients often attempt to shorten the time consuming administration procedure by mixing drug solutions/suspensions for simultaneous inhalation. This article considers the issue of physico-chemical compatibility of admixtures of drug solutions/suspensions in nebulizers.A search of databases, prescribing information and primary literature was conducted to locate literature concerning the physico-chemical compatibility of inhalation solutions/suspensions. This was supplemented by telephone interviews.Admixtures of albuterol with ipratropium and/or cromolyn, of albuterol and budesonide, or tobramy…
Techniques to measure sorption and migration between small molecules and packaging. A critical review
2015
The mass transfer parameters diffusion and sorption in food and packaging or between them are the key parameters for assessing a food product's shelf-life in reference to consumer safety. This has become of paramount importance owing to the legislations set by the regulated markets. The technical capabilities that can be exploited for analyzing product–package interactions have been growing rapidly. Different techniques categorized according to the state of the diffusant (gas or liquid) in contact with the packaging material are emphasized in this review. Depending on the diffusant and on the analytical question under review, the different ways to study sorption and/or migration are present…
Erysacleuxins C and D, new isoflavones from the twigs of Erythrina sacleuxii Hua and their cytotoxic activity
2020
Two previously undescribed isoflavones, erysacleuxin C (1) and erysacleuxin D (2), together with seven known compounds (3–9), were isolated and identified from the EtOAc extract of the twigs of Erythrina sacleuxii Hua (Leguminosae). The structures of the isolated compounds were determined on the basis of their spectroscopic and spectrometric data. Evaluation of their cytotoxicity against the human cancer HeLa-S3 cell lines indicated IC50 values of 130.4, 54.9 and 73.9 µM for erysacleuxin C (1), erysacleuxin D (2) and butin (9), respectively. Keywords: Erythrina sacleuxii, Leguminosae, Isoflavone, Erysacleuxin C, Erysacleuxin D, Cytotoxicity
Bārtas upes hidroloģiskā un hidroķīmiskā režīma ilgtermiņa un sezonālās izmaiņas
2016
Bakalaura darba tēma: “Bārtas upes hidroloģiskā un hidroķīmiskā režīma ilgtermiņa un sezonālās izmaiņas”. Bakalaura darba mērķis ir izvērtēt Bārtas upes hidroloģiskā un hidroķīmiskā režīma ilgtermiņa un sezonālās izmaiņas un to ietekmējošos faktorus. Pētījumā ir izmantotas hidroloģisko un hidroķīmisko novērojumu datu kopas no Bārta-Dūkupji novērojumu stacijas, atbilstoši no 1951.-2008.gadam un no 1978.-2008.gadam, kā arī meteoroloģisko novērojumu datu rindas no Liepājas stacijas no 1966.-2008.gadam. Monitoringu novērojumu datu apstrādē un analīzē pielietotas matemātiskās statistikas metodes. Pētījums parādīja, ka Bārtas upes hidroķīmiskais režīms ir cieši saistīts ar hidroloģiskā režīma izm…
Chemical Identification at the Solid–Liquid Interface
2017
Solid-liquid interfaces are decisive for a wide range of natural and technological processes, including fields as diverse as geochemistry and environmental science as well as catalysis and corrosion protection. Dynamic atomic force microscopy nowadays provides unparalleled structural insights into solid-liquid interfaces, including the solvation structure above the surface. In contrast, chemical identification of individual interfacial atoms still remains a considerable challenge. So far, an identification of chemically alike atoms in a surface alloy has only been demonstrated under well-controlled ultrahigh vacuum conditions. In liquids, the recent advent of three-dimensional force mapping…
APPROCCIO FARMACOLOGICO NEL PAZIENTE CON MALATTIA NON SUSCETTIBILE DI TERAPE LOCO-REGIONALI AD INTENTO CURATIVO.
2006
Potential models for the simulation of methane adsorption on graphene: development and CCSD(T) benchmarks
2018
Different force fields for the graphene–CH4 system are proposed including pseudo-atom and full atomistic models. Furthermore, different charge schemes are tested to evaluate the electrostatic interaction for the CH4 dimer. The interaction parameters are optimized by fitting to interaction energies at the DFT level, which were themselves benchmarked against CCSD(T) calculations. The potentials obtained with both the pseudo-atom and full atomistic approaches describe accurately enough the average interaction in the methane dimer as well as in the graphene–methane system. Moreover, the atom–atom potentials also correctly provide the energies associated with different orientations of the molecu…
Delivering all in one: Antigen-nanocapsule loaded with dual adjuvant yields superadditive effects by DC-directed T cell stimulation
2018
Therapeutic vaccination is and remains a major challenge, particularly in cancer treatment. In this process, the effective activation of dendritic cells by a combination of distinctly acting adjuvants and an antigen is crucial for success. While most common vaccine formulations lack the efficiency to trigger sufficient T cell responses in a therapeutic tumor treatment, nanovaccines offer unique properties to tackle that challenge. Here, we report the stepwise development of a nanocapsule for vaccination approaches, comprising a shell consisting of antigen and loaded with a superadditive adjuvant combination. In a first initial step, we identified the combination of resiquimod (R848) and mur…
Analītiskās metodes izstrāde mikotoksīnu noteikšanai notekūdens paraugos
2021
Analītiskās metodes izstrāde mikotoksīnu noteikšanai notekūdens paraugos. Pavļenko R., zinātniskais vadītājs Dr. ķīm., prof. Bartkevičs V. Bakalaura darbs, 49 lappuses, 27 attēli, 18 tabulas, 35 literatūras avoti, 1 pielikums. Latviešu valodā. Mikotoksīni ir toksiskie pelējuma sēnīšu metabolisma produkti, kas rodas, sēnītēm augot pārtikā, kā arī apkārtējā vidē. Ir pierādīts, ka mikotoksīnu izplatība pārtikā var izraisīt negatīvu ietekmi uz cilvēku veselību. Šī darba mērķis ir izstrādāt metodi mikotoksīnu noteikšanai notekūdens paraugos, lai turpmākajos pētījumos būtu iespēja aprēķināt, izmantojot 5-hidroksiindoletiķskābi kā populācijas biomarķieri, iedzīvotāju ekspozīciju ar mikotoksīniem. …
Tensile behaviour of anti-symmetric CFRP composite
2011
Abstract This paper addresses the response of a 17-ply anti-symmetric carbon/epoxy composite subjected to uniaxial tensile loading. Hashin ply damage model is adopted to describe the damage behaviour of the plies, whereas damage initiation and progression of the interfaces are characterised by mixed-mode cohesive damage model. Force-displacement curves obtained numerically and experimentally show good agreement. Results show that all laminae and interfaces experience the damage except laminae with 0o fibre. In addition, damage is concentrated at the tab and central regions of the tensile specimen. Edge delamination is observed in all interfaces.