Search results for "Note"

Thermo-, piezo-, photo- and chemo-switchable spin crossover iron(II)-metallocyanate based coordination polymers

2011

Abstract The design of coordination polymers (CPs) with switch and memory functions is an important subject of current interest in the search for new advanced materials with potential applications. Implementation of CPs with electronically labile iron(II) building blocks able to undergo cooperative spin crossover (SCO) behavior is a singular approach to this end. This review provides an up to date survey of a new generation of iron(II)-metallocyanate based spin crossover coordination polymers (SCO-CPs) developed during the last decade. These new solids feature structural diversity, supramolecular isomerism, interpenetrating frameworks, structure flexibility, reversible solid-state chemical …

Modelling retention and peak shape of small polar solutes analysed by nano-HPLC using methacrylate-based monolithic columns.

2019

Abstract The development of methacrylate-based monolithic columns was studied for the separation of pharmaceutical hydrophilic compounds in nano-liquid chromatography. The selected polymerisation mixture consisted of 7.5% hexyl methacrylate, 4.5% methacrylic acid and 18.0% ethylene dimethacrylate (w/w), in a binary porogenic solvent (35:35 w/w 1-propanol/1,4-butanediol). The polymer synthesised with this mixture has a good permeability, not excessive back-pressure, and reasonable retention times for polar and non-polar solutes. Monolithic columns (12 cm total capillary length, 100 μm i.d.), prepared with this mixture, were able to produce hydrogen bonding and electrostatic interactions, giv…

Pretreatment and fractionation of lignocellulosic barley straw by mechanocatalysis

2017

Abstract This study focuses on the mechanocatalytical process combining dilute acid pretreatment and mechanical processing driven by ball milling. Milled and hydrolyzed barley straw samples are subject to reducing sugar analysis by DNS assay and capillary electrophoresis. Optimization of the saccharification conditions was carried out with two different sulfuric acid concentrations, 0.5 mol kg −1 and 1.0 mol kg −1 , and compared. A significant yield of total reducing sugar (53.4%) was obtained from barley straw impregnated with sulfuric acid (1.0 mol kg −1 ) after milling for only 20 min. Glucose and xylose concentrations accounted for 3.5% and 11.3%, respectively. Strikingly, the present s…

Luminometric sub-nanoliter droplet-to-droplet array (LUMDA) and its application to drug screening by phase I metabolism enzymes.

2012

Here we show the fabrication of the Luminometric Sub-nanoliter Droplet-to-droplet Array (LUMDA chip) by inkjet printing. The chip is easy to be implemented and allows for a multiplexed multi-step biochemical assay in sub-nanoliter liquid spots. This concept is here applied to the integral membrane enzyme CYP3A4, i.e. the most relevant enzymatic target for phase I drug metabolism, and to some structurally-related inhibitors.

Structure and luminescence properties of supramolecular polymers of amphiphilic aromatic thioether–peptide conjugates in water

2019

We present the preparation of luminophore–peptide conjugates that self-assemble into supramolecular polymers in neutral buffer. To this end, we have prepared a small library of six conjugates with varying substitution patterns of the aromatic thioethers, as well as varying amino acid sequences. The latter have allowed us to tune the thermodynamic driving force for self-assembly and probe their photoluminescent properties either in the monomeric or polymeric state, while fully avoiding selective solvent techniques or organic solvent mixtures. All of the supramolecular structures were characterised with transmission electron microscopy, circular dichroism measurements, as well as steady-state…

Polymeric janus particles.

2009

Since de Gennes' Nobel lecture in 1991, in which he coined the term "Janus grains", research into asymmetric particles has boomed. Macroscopic, microscopic and nanoscopic particles have been prepared in which certain parts of their surface differ in chemical composition, polarity, color, or any other property. Spherical, cylindrical, disc-like, snowman-, hamburger-, and raspberry-like structures have been synthesized from organic or inorganic materials or even as hybrids of both. Synthetic strategies towards such particles vary greatly from simple polymer mixtures to the bulk self-assembly of sophisticated terpolymers to immobilization methods of symmetric particles. Polymeric Janus particl…

Dye loading of amphiphilic poly(organosiloxane) nanoparticles.

2003

Metal-organic frameworks conjugated with biomolecules as efficient platforms for development of biosensors

2021

Abstract Recent developments in the field of metal-organic frameworks (MOFs) have renewed the interests of scientists to bring about a major breakthrough in this field soon. These particles consist of ultra-highly porous and tremendous internal surface areas with extraordinary variabilities that make them highly potent compounds in nanomedicine. Moreover, low weight, large free volumes, and multiple functionalities of these particles have made them extremely attractive for various applications. Along with a critical role in the adsorption and separation of different analytes, they also have an immense role in the development of biosensor platforms that are expected to pave the way for accur…

Aptamer-based assay of biomolecules: Recent advances in electro-analytical approach

2017

Electrochemical aptasensors, which are based on the specificity of aptamer-target recognition, with electrochemical transduction for analytical purposes have received particular attention due to their high sensitivity and selectivity, simple instrumentation, as well as low production cost. This review summarizes advances from 2009 to January 2017 in the development of electrochemical aptasensors for biological molecules, including small molecules, nucleic acids, and proteins. Various aptasensing strategies are assessed according to their potential for reaching relevant limits of sensitivity, specificity, and degrees of multiplexing. Furthermore, we address the remaining challenges and oppor…

Synthesis of Precision Poly(1,3-adamantylene alkylene)s via Acyclic Diene Metathesis Polycondensation

2019

[Image: see text] Fully saturated, aliphatic polymers containing adamantane moieties evenly distributed along the polymer backbone are of great interest due to their exceptional thermal stability, yet more synthetic strategies toward these polymers would be desirable. Herein, we report for the first time the synthesis of poly(1,3-adamantylene alkylene)s based on α,ω-dienes containing bulky 1,3-adamantylene defects precisely located on every 11th, 17th, 19th, and 21st chain carbon via acyclic diene metathesis polycondensation. All saturated polymers revealed excellent thermal stabilities (452–456 °C) that were significantly higher compared to those of structurally similar polyolefins with al…