Search results for "Novas"
showing 10 items of 30 documents
Triptans and CGRP blockade - impact on the cranial vasculature.
2017
Abstract The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including serotonin and calcitonin gene-related peptide (CGRP), which modulate pain transmission and vascular tone. Thirty years after discovery of agonists for serotonin 5-HT1B and 5-HT1D receptors (triptans) and less than fifteen after the proof of concept of the gepant class of CGRP receptor antagonists, we are still a long way from understanding their precise site and mode of action in migraine. The effect on cranial vasculature is relevant, because all specific anti-migraine drugs and mig…
Screening for congenital renovascular hypoplasia and renal artery stenosis by acute converting enzyme inhibition.
1993
To evaluate the usefulness of the captopril test for identifying renal artery stenosis (RAS) and renovascular hypoplasia (RAH), we studied 48 hypertensive patients. In 20 hypertensives with screening procedures indicating renovascular disease and in 28 essential hypertensives (EH), the plasma renin activity (PRA) responses to an oral test dose of captopril (50 mg) were studied. A 60-min post-captopril PRA increase of 150% (or 400% if baseline PRA < or = 3 ng/ml/h) was considered as positive. Renal angiography was performed in all cases. Among the 20 renovascular hypertensive patients, RAH in 9 and RAS in 11 subjects were proved by angiography. The captopril test in all patients with RAH res…
Comparison of tumour necrosis factor and endothelin-1 between essential and renal hypertensive patients
1998
The present study was performed to compare circulating levels of tumour necrosis factor-alpha (TNFalpha) and plasma endothelin 1 (ET-1), of hypertensive patients with or without renal failure and with those of normotensive healthy subjects. The study population consisted of 21 healthy normotensive subjects and 22 hypertensive patients, 11 with essential hypertension, and 11 with hypertension and chronic renal failure (CRF). Plasma ET-1 levels, serum TNFalpha and creatinine, creatinine clearance, 24-h urinary albumin excretion (UAE) were assayed, and 24-h blood pressure monitoring was obtained in all subjects. Office blood pressure was similar between hypertensive patients with and without C…
Ambulatory blood pressure during diseases of the kidney
1999
During the last few years there has been a renewal of interest in blood-pressure-induced kidney damage due to a progressive increase in the incidence and prevalence of hypertension and vascular diseases as a cause of end-stage renal disease (ESRD). The need to prevent ESRD demands a continuation of effort to make the early identification of hypertensives who are at risk possible and to provide them with effective antihypertensive therapy. Since ambulatory blood pressure monitoring has been used successfully to assess blood pressure and identify risk markers for cardiovascular diseases, a logical approach would be to use it also to identify the risk markers for ESRD. Higher than normal perce…
One coast, two systems: Regional innovation systems and entrepreneurial discovery in Western Norway
2021
This paper introduces an analytical framework for understanding how specialized and diversified regional innovation system (RIS) differ in the way an entrepreneurial discovery process (EDP) is likely to unfold. To analytically explore the proposed framework, we deploy a sequential explanatory design approach, using quantitative data to analyze the regional industry structure of the city regions of Bergen and Stavanger in Western Norway, followed by a qualitative analysis of interviews with key stakeholders in both regions. We find that the city regions face unique challenges that align with an understanding of their respective RIS categorization, providing evidence that the framework propos…
Organisasjonslæring og innovasjon i Nøsted Kjetting AS
2014
Masteroppgave i industriell økonomi og teknologiledelse IND 590 Universitetet i Agder 2014 Norsk industri er stadig i nedgang. Etter oljeproduksjonens begynnelse på starten av 1970 tallet har antall arbeidsplasser i industrien sunket drastisk. Dette kommer blandt annet av et stadig økende kostnadsnivå og økt internasjonal konkurranse. Til tross for dette så har en liten kjettingprodusent fra Mandal klart å overkomme alle hindringer, og er i dag norges eneste gjenlevende kjettingprodusent. Deres 75 år lange historie består av mange oppturer og nedturer. Etter bedriftens oppstart i 1939 hadde de en stor utvikling de første 30 årene. De automatiserte og ekspanderte, og ble etterhvert en av nor…
Zvaigžnotā Debess: 2007, Vasara
2007
Latvijas Zinātnes padome, Latvijas Universitāte
Relationship between transforming growth factor beta1 and progression of hypertensive renal disease.
2002
In this study the role of circulating transforming growth factor beta1 (TGFbeta1) on progression of renal hypertensive disease has been investigated. Fifty consecutive outpatients with essential hypertension were enrolled and divided into three groups, according to their urinary albumin excretion (UAE). Group A comprised 10 hypertensives with UAEor=20 mg/24 h (normoalbuminuric group); Group B included 21 hypertensives with UAE20300 mg/24 h (microalbuminuric group); Group C encompassed 19 hypertensives with UAEor= 300 mg/24 h (proteinuric group). In all patients UAE by immunonephelometric assay, circulating TGFbeta1 by a solid phase specific sandwich ELISA technique, BUN and creatinine by ro…
Collaborative Management in Norwegian Municipalities: Do Middle Managers Make a Difference?
2022
Norway is an example of the Nordic model in which the local level is of fundamental importance. However, the municipalities are relatively small and increasingly subject to decentralisation of their activities. To compensate for scale disadvantages, a mixture of collaborative activities is pursued in order to build system capacity. Paradoxically, little is known about collaboration among key stakeholders. This article makes a contribution to reducing this knowledge gap by focusing on mid-level managers and municipal departments. This research is empirically underpinned by a cross sectional survey of middle managers in 64 municipalities in Norway (N = 1354) and presents, for the first time, …
Tomography of the SN 1987A ejecta and AGN core-shifts with high-precision astrometry
2017
Esta tesis trata dos temas muy distintos: (1) el estudio de las estructuras y movimientos propios de los chorros de los núcleos activos de galaxias (AGN) que componen la muestra S5 del casquete polar, por medio de astrometría global de alta precisión con la técnica de interferometría de muy larga base (VLBI); y (2) la reconstrucción tomográfica (i.e., 3D) de la emisión molecular de la parte interna de la supernova SN 1987A y su comparación con modelos de explosión de supernovas. En la primera parte, presentamos el análisis astrométrico diferencial llevado a cabo para todas las fuentes de la muestra S5 del casquete polar. Se consigue aplicar por primera vez a 43 GHz la técnica de astrometría…