Search results for "Numa"
showing 10 items of 74 documents
VALUTAZIONE DELLA CRESCITA IN PAZIENTI CON ARTRITE IDIOPATICA GIOVANILE SISTEMICA
2021
IL-1 BLOCKADE IN PAEDIATRIC RECURRENT PERICARDITIS: A MULTICENTRIC RETROSPECTIVE STUDY OF THE ITALIAN COHORT
2019
Introduction: Acute pericarditis is an inflammatory condition causing the occurrence of pericardial effusion. In a third of patients, the disease is recurrent. First line treatment of idiopathic pericarditis consists in non-steroidal anti-inflammatory drugs (NSAIDs) and colchicine; glucocorticoids represent the second line treatment in resistant or intolerant cases. A recent clinical trial has enlightened the effectiveness of anakinra in adults and paediatric patients with colchicine-resistant recurrent pericarditis. Objectives: To describe the clinical characteristics and response to treatment in a cohort of paediatric patients with recurrent pericarditis treated with IL inhibitors. Method…
Canakinumab in systemic juvenile idiopathic arthritis: clinical inactive disease rate and safety in italian patients
2019
Introduction: Systemic juvenile idiopathic arthritis (sJIA) is a polygenic autoinflammatory disease. The pathophysiology is still unclear, it is now well known that innate immune mechanisms play a central role with overproduction of inflammatory cytokines. The increased knowledge on the role of these cytokines has provided a change in the natural history of the disease with the introduction of the targeted treatments. Remarkable results has been observed with canakinumab, an anti-interleukin-1β monoclonal antibody, in two clinical trials but little information are available in real life. Objectives: To evaluate clinical inactive disease rate and safety of canakinumab in Italian patients wit…
Tasso di persistenza in terapia di anakinra e canakinumab nelle malattie autoinfiammatorie monogeniche: studio osservazionale dal registro internazio…
2021
Real-world evidence of biologic treatments in psoriatic arthritis in Italy: results of the CHRONOS (EffeCtiveness of biologic treatments for psoriati…
2022
Abstract Background Biologics have demonstrated efficacy in PsA in randomized clinical trials. More evidence is needed on their effectiveness under real clinical practice conditions. The aim of the present work is to provide real-world evidence of the effectiveness of biologics for PsA in the daily clinical practice. Methods CHRONOS was a multicenter, non-interventional, cohort study conducted in 20 Italian hospital rheumatology clinics. Results 399 patients were eligible (56.9% females, mean (SD) age: 52.4 (11.6) years). The mean (SD) duration of PsA and psoriasis was 7.2 (6.9) and 15.3 (12.2) years, respectively. The mean (SD) duration of the biologic treatment under analysis was 18.6 (6.…
IL POPOLAMENTO DI THARROS IN ETÀ FENICIA E PUNICA. ANALISI ANTROPOLOGICHE PRELIMINARI DALLA NECROPOLI MERIDIONALE DI CAPO SAN MARCO (PENISOLA DEL SIN…
2020
Si riportano i primi dati dell’analisi antropologica eseguita sui resti scheletrici recuperati, da deposizioni primarie e secondarie, durante le recenti campagne di scavo effettuate nella necropoli meridionale di Tharros nell’ambito della Concessione ministeriale di ricerche e scavi archeologici in carico all’Università di Bologna. Tale studio rappresenta una nota preliminare dell’indagine bioarcheologica in corso ad opera del Laboratorio di Antropologia dell’Università degli Studi di Palermo con la Scuola di Specializzazione in Beni archeologici dell’Università di Bologna, sui resti antropologici tharrensi, e si inserisce in un più ampio progetto di ricerca rivolto alla ricostruzione del p…
Numa Denis Fustel de Coulanges, Leçons sur Sparte
2013
International audience
La interpretación de los riesgos naturales y el cambio climático en postgrado. Ejemplos de casos de estudio en la provincia de Alicante (España)
2020
Esta investigación tiene el objetivo de exponer una experiencia didáctica sobre la interpretación de los riesgos naturales y el cambio climático a partir de la propuesta de diferentes estudios de caso de la provincia de Alicante (España). Dicha propuesta se lleva a cabo en la asignatura de Cambio Climático y Riesgo en el Mediterráneo del Máster en Planificación y Gestión de Riesgos Naturales (Universidad de Alicante). Metodológicamente se han expuesto diferentes ejemplos de análisis sobre las temáticas de: 1) Las sequías; 2) La explotación y sangrado de cursos fluviales; 3) Tendencias climáticas; y 4) Medidas de adaptación al cambio climático. Con estos ejemplos se pretende que los discente…
Erenumab and Possible CGRP Effect on Chronotype in Chronic Migraine: A Real-Life Study of 12 Months Treatment
2023
The introduction of monoclonal antibodies (mAbs) directed against the calcitonin gene-related peptide (CGRP), or its receptor (CGRPr), revolutionized migraine management due to their high efficacy and few side effects. Data suggest that the CGRP may even be implicated in circadian rhythm, but studies about the effect of anti-CGRP treatments on sleep are still lacking. The aim of the present study was to assess the effect of erenumab (70 and 140 mg per month), a human mAb directed against CGRPr, on chronotype in chronic migraineurs; secondly, we assessed its efficacy, safety, and the effects on anxiety and depression. Sleep was evaluated using self-administrable questionnaires investigating …