Search results for "OCAI"
showing 10 items of 237 documents
Organizācijas kultūra attālinātā darba formātā uzņēmumā SIA „Euroaptieka”
2022
Bakalaura darba tēma ir organizācijas kultūra attālinātā darba formātā uzņēmumā SIA „Euroaptieka”. Darba mērķis ir izstrādāt uzņēmuma SIA „Euroaptieka” organizācijas kultūras pilnveides pasākumus darbam attālinātā formātā, lai sasniegtu šo mērķi tika izvirzīti šādi uzdevumi - pamatojoties uz zinātnisko literatūru, novērtēt organizācijas kultūru; noskaidrot attālinātā darba formāta; raksturot uzņēmumu SIA „Euroaptieka” esošos procesus; izmantojot OCAI - Organizācijas kultūras vērtēšanas instrumentu, izvērtēt darbinieku viedokļus par esošo un vēlamo organizācijas kultūru; analizēt iegūtos aptauju rezultātus un izdarīt secinājumus; veikt secinājumus un izstrādāt priekšlikumus, lai uzlabotu org…
Nanomaterial-based cocaine aptasensors.
2015
Up to now, many different methods have been developed for detection of cocaine, but most of these methods are usually time-consuming, tedious and require special or expensive equipment. Therefore, the development of simple, sensitive and rapid detection methods is necessary. In the last decade, aptamers have been used as a new biosensor platform for detection of cocaine in different samples. Aptamers are artificial single-stranded DNA or RNA oligonucleotides capable of binding to specific molecular targets with high affinity and if integrated to nanomaterials, it may lead in precise methods for cocaine detection in the common laboratories. In this review, recent advances and applications of…
Organizācijas kultūras pilnveides iespējas Salaspils 1.vidusskolā
2019
Bakalaura darbā “Organizācijas kultūras pilnveides iespējas Salaspils 1. vidusskolā” autors Sandijs Krastiņš pēta un sniedz priekšlikumus organizācijas kultūras pilnveidošanai Salaspils 1. vidusskolā. Salaspils 1. vidusskola patreiz atrodas organizatorisko pārmaiņu procesā. Skola savā pārvaldībā ieguvusi jaunu ēku, kas platības ziņā ir līdzvērtīga vecajai. Organizācijas izvietojums divās atsevišķās ēkās tai ir kas jauns. Turklāt, darbā tika pieņemts daudz jaunu darbinieku. Tāpēc ir svarīgi apzināt esošo situāciju, lai organizācijas vadība spētu veikt nepieciešamās darbības organizācijas kultūras uzlabošanai vēlamajā virzienā. Darbam ir 2 nodaļas – pirmajā autors analizē organizācijas kultūr…
Étude des caractéristiques cliniques et biologiques des patients marocains COVID-19 avec et sans dysfonctionnement olfactif et/ou gustatif
2021
Introduction et but de l’etude L’epidemie de coronavirus-2 du syndrome respiratoire aigu severe (SRAS-CoV-2), a l’origine de la maladie a coronavirus 2019 (COVID-19), presente une menace importante et urgente pour la sante mondiale. Cette infection virale alarmante, declaree pandemique par l’OMS en fevrier 2020, a entraine des millions de patients infectes et des milliers de morts dans le monde. Au Maroc, malgre les efforts fournis par les autorites, le SRAS-CoV-2 continue de se propager et constitue un fardeau de morbidite et de mortalite. L’objectif de cette etude est de decrire les caracteristiques cliniques des patients marocains COVID-19 et d’etablir la relation entre des symptomes cli…
Bilateral Transcranial Magnetic Stimulation of the Prefrontal Cortex Reduces Cocaine Intake: A Pilot Study
2016
Background Chronic cocaine consumption is associated with a decrease in mesolimbic dopamine transmission that maintains drug intake. transcranial magnetic stimulation (TMS) is gaining reliability, a useful therapeutic tool in drug addiction, since it can modulate cortico-limbic activity resulting in reduction of drug craving. Aims In the present study, we investigated the therapeutic effect of bilateral TMS of prefrontal cortex (PFC) in reducing cocaine intake, in a sample of treatment-seeking patients with current cocaine use disorder (DSM-V). Methods Ten cocaine addicts (DSM-V) were randomly assigned to the active or sham stimulation protocol in a double-blind experimental design. Twelve …
Postsynaptic NO/cGMP Increases NMDA Receptor Currents via Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in the Hippocampus
2013
The nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling cascade participates in the modulation of synaptic transmission. The effects of NO are mediated by the NO-sensitive cGMP-forming guanylyl cyclases (NO-GCs), which exist in 2 isoforms with indistinguishable regulatory properties. The lack of long-term potentiation (LTP) in knock-out (KO) mice deficient in either one of the NO-GC isoforms indicates the contribution of both NO-GCs to LTP. Recently, we showed that the NO-GC1 isoform is located presynaptically in glutamatergic neurons and increases the glutamate release via hyperpolarization-activated cyclic nucleotide (HCN)-gated channels in the hippocampus. Electrophysiologi…
Three Patterns of Oscillatory Activity Differentially Synchronize Developing Neocortical Networks In Vivo
2009
Coordinated patterns of electrical activity are important for the early development of sensory systems. The spatiotemporal dynamics of these early activity patterns and the role of the peripheral sensory input for their generation are essentially unknown. We performed extracellular multielectrode recordings in the somatosensory cortex of postnatal day 0 to 7 rats in vivo and observed three distinct patterns of synchronized oscillatory activity. (1) Spontaneous and periphery-driven spindle bursts of 1-2 s in duration and approximately 10 Hz in frequency occurred approximately every 10 s. (2) Spontaneous and sensory-driven gamma oscillations of 150-300 ms duration and 30-40 Hz in frequency oc…
Resilience to social defeat stress in adolescent male mice.
2022
Adverse social experiences during adolescence are associated with the appearance of mental illness in adulthood. Social defeat (SD) is an ethologically valid murine model to study the consequences of social stress. In adolescent mice, SD induces depressive-like behaviors, increased anxiety and potentiates the reinforcing effects of cocaine and alcohol. However, not all mice exposed to SD will be susceptible to these effects. Adult mice resilient to the effects of SD show a consistent phenotype being resilient to depressive-like behaviors and to the increase in cocaine and alcohol consumption. The aim of the present study was to characterize the resilient phenotype to depressive-like behavio…
Mitochondrial basis of the anti-arrhythmic action of lidocaine and modulation by the n-6 to n-3 PUFA ratio of cardiac phospholipids
2012
The aim of this study was to evaluate the involvement of mitochondria in the mechanism of the anti-arrhythmic lidocaine. Rats were fed with a diet containing either n-6 polyunsaturated fatty acids (PUFAs, SSO group) or an equimolecular mixture of n-3 and n-6 PUFAs (FO group) for 8 weeks. The hearts were perfused according to the working mode using a medium with or without lidocaine 5 μM. They were then subjected to local ischemia (20 min) and reperfusion (30 min). Dietary n-3 PUFAs triggered the expected decrease in the n-6/n-3 PUFA ratio of cardiac phospholipids. Reperfusing the ischemic area favored the incidence of severe arrhythmias. Lidocaine treatment abolished almost completely reper…
Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters
2001
1. The release of acetylcholine was investigated in the human placenta villus, a useful model for the characterization of the non-neuronal cholinergic system. 2. Quinine, an inhibitor of organic cation transporters (OCT), reduced acetylcholine release in a reversible and concentration-dependent manner with an IC(50) value of 5 microM. The maximal effect, inhibition by 99%, occurred at a concentration of 300 microM. 3. Procaine (100 microM), a sodium channel blocker, and vesamicol (10 microM), an inhibitor of the vesicular acetylcholine transporter, were ineffective. 4. Corticosterone, an inhibitor of OCT subtype 1, 2 and 3 reduced acetylcholine in a concentration-dependent manner with an IC…