Search results for "OCTA"

showing 10 items of 1862 documents

Identification of the Tetraspanin CD9 as an Interaction Partner of Organic Cation Transporters 1 and 2

2019

Organic cation transporters (OCTs) are membrane proteins with relevant physiological (because they accept neurotransmitters as substrate) and pharmacological (because of their interaction with drugs) roles. The human OCTs hOCT1 (SLC22A1/hOCT1) and hOCT2 (SLC22A2/hOCT2) are highly expressed in hepatic (hOCT1) and in renal and neuronal tissue (hOCT2), suggesting a possible role in modulating neurotransmitter activity in the liver, kidney, and brain, and their clearance from the blood. Even though there are several data demonstrating that OCTs are regulated under various patho-physiological conditions, it remains largely unknown which proteins directly interact with OCTs and thereby influence …

0301 basic medicineTetraspaninsEndosome610BiochemistryInteractomeTetraspanin 29Madin Darby Canine Kidney CellsAnalytical Chemistry03 medical and health sciencesDogs610 Medical sciences MedicineTetraspaninAnimalsHumansCellular localizationOrganic cation transport proteins030102 biochemistry & molecular biologybiologyChemistryCell MembraneMembrane ProteinsOrganic Cation Transporter 2TransporterCompartmentalization (psychology)Cell biologyProtein TransportHEK293 Cells030104 developmental biologyMembrane proteinembryonic structuresbiology.proteinMolecular MedicineOctamer Transcription Factor-1Biotechnology
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Maternal Perfluoroalkyl Substances, Thyroid Hormones, and DIO Genes: A Spanish Cross-sectional Study

2021

Results of studies on perfluoroalkyl substances (PFASs) and thyroid hormones (THs) are heterogeneous, and the mechanisms underlying the action of PFASs to target THs have not been fully characterized. We examined the relation between first-trimester maternal PFAS and TH levels and the role played by polymorphisms in the iodothyronine deiodinase 1 (DIO1) and 2 (DIO2) genes in this association. Our sample comprised 919 pregnant Spanish women (recruitment = 2003-2008) with measurements of perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorononanoic acid (PFNA), thyroid-stimulating hormone (TSH), total triiodothyronine (TT3), and fr…

0303 health sciencesmedicine.medical_specialtyPerfluorooctanesulfonic acidTriiodothyronineCross-sectional studyDIO2General Chemistry010501 environmental sciencesBiology01 natural sciencesPerfluorononanoic acid03 medical and health scienceschemistry.chemical_compoundEndocrinologychemistryInternal medicinemedicineEnvironmental ChemistryPerfluorooctanoic acidGene030304 developmental biology0105 earth and related environmental sciencesHormoneEnvironmental Science & Technology
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The influence of storage conditions on flavour changes in human milk

2009

http://www.sciencedirect.com/ ; http://www.elsevier.com/; International audience; The effects of freeze-storage on human milk have been investigated with regard to sensory changes and modifications in the molecular composition of constituent odour-active volatiles. Sensory evaluation showed that fishy-metallic odour attributes are generated during storage, as are rancid-sweaty odour notes, which were described by panellists to be highly unpleasant. To monitor the dynamics of off-odour development in human milk, sensory evaluation in both orthonasal and retronasal mode was performed at defined time intervals of storage, with parallel evaluation of human milk samples that had been heated prio…

030309 nutrition & dietetics[ SDV.AEN ] Life Sciences [q-bio]/Food and NutritionFlavourFood storageBreastfeeding03 medical and health sciences0404 agricultural biotechnology[SDV.IDA]Life Sciences [q-bio]/Food engineeringparasitic diseasesAcidGas chromatography olfactometryFood science(Z)-Octa-15-dien-3-oneGeneralLiterature_REFERENCE(e.g.dictionariesencyclopediasglossaries)FlavorComputingMilieux_MISCELLANEOUS2. Zero hungerchemistry.chemical_classification0303 health sciencesNutrition and DieteticsFishyOff-flavourFood preservationfood and beveragesFood composition data04 agricultural and veterinary sciences[SDV.IDA] Life Sciences [q-bio]/Food engineering040401 food scienceOff-flavourchemistryBiochemistryMetallicFood quality[SDV.AEN]Life Sciences [q-bio]/Food and NutritionFood SciencePolyunsaturated fatty acid
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CCDC 2211279: Experimental Crystal Structure Determination

2023

Related Article: Anssi Peuronen, Anni Taponen, Elina Kalenius, Ari Lehtonen, Manu Lahtinen|2023|Angew.Chem.,Int.Ed.|62|e202215689|doi:10.1002/anie.202215689

11'1''-[(246-trimethylbenzene-135-triyl)tris(methylene)]tris(14-diazabicyclo[2.2.2]octan-1-ium) iodide bis(bis(trifluoromethanesulfonyl)azanide) acetonitrile solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 289303: Experimental Crystal Structure Determination

2007

Related Article: K.Laihia, A.Valkonen, E.Kolehmainen, A.Antonov, D.Zhukov, I.Fedosov, V.Nikiforov|2006|J.Mol.Struct.|800|100|doi:10.1016/j.molstruc.2006.03.095

11'22'5'6'7'7a'-octahydro-2-oxo-1'-nitro-2'-(4''-chlorophenyl)-spiro(3H-indole-33'-(3H)-pyrrolizine)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1014200: Experimental Crystal Structure Determination

2014

Related Article: Hai Yi, Markus Albrecht, Arto Valkonen, Kari Rissanen|2015|New J.Chem.|39|746|doi:10.1039/C4NJ01654H

11'-((22'33'55'66'-octafluorobiphenyl-44'-diyl)bis(methylene))bis-4-aza-1-azoniabicyclo[2.2.2]octane dibromideSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1425258: Experimental Crystal Structure Determination

2016

Related Article: T. Mäkelä, K. Rissanen|2016|Dalton Trans.|45|6481|doi:10.1039/C6DT00414H

11'-(2356891112-Octahydro-1471013-benzopentaoxacyclopentadecine-1516-diyl)bis(3-(4-nitrophenyl)urea) NN-dimethylformamide solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1023704: Experimental Crystal Structure Determination

2014

Related Article: Anssi Peuronen, Heikki Rinta, Manu Lahtinen|2015|CrystEngComm|17|1736|doi:10.1039/C4CE01866D

11'-hexane-16-diylbis(4-diiodaniumyl-14-diazoniabicyclo[2.2.2]octane) bis(hexafluorophosphate)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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Synthesis of a Tetraazido-Substituted 2-Tetrazene from 1,5-Cyclooctadiene and Iodine Azide

1997

In contrast to the addition of iodine azide to cyclooctene (1) or 1,3-cyclooctadiene (5), its reaction with 1,5-cyclooctadiene (12) leads mainly to the surprisingly stable tetraazido-substituted 2-tetrazene 14 The structure of this was established by 15N-NMR studies and an X-ray structural analysis. Treatment of 14 with hydrochloric acid yields the diazido-substituted 9-azabicyclo[3.3.1]nonane 20.

15-CyclooctadieneOrganic Chemistrychemistry.chemical_elementHydrochloric acidGeneral ChemistryIodineMedicinal chemistrychemistry.chemical_compoundchemistryCycloocteneTetrazeneOrganic chemistryAzidePhysical and Theoretical ChemistryNonaneLiebigs Annalen
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CCDC 817434: Experimental Crystal Structure Determination

2011

Related Article: M.Giese, M.Albrecht, C.Bannwarth, G.Raabe, A.Valkonen, K.Rissanen|2011|Chem.Commun.|47|8542|doi:10.1039/c1cc12667a

1-(26-Difluorobenzyl)-4-aza-1-azoniabicyclo[2.2.2]octane bromide monohydrateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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