Search results for "ODR"
showing 10 items of 434 documents
Nenodrošinātā kreditora tiesību īstenošanas problemātika mantojuma lietā
2019
Bakalaura darba “Nenodrošinātā kreditora tiesību īstenošanas problemātika mantojuma lietā” mērķis ir noskaidrot tiesiskā regulējuma gadījumus, kas ir nenodrošinātā kreditora tiesību īstenošanas problemātikas pamatā mantojuma lietā. Tāpat mērķis ir noskaidrot, vai nenodrošinātā kreditora kā tiesību subjekta tiesības ir samērotas ar citu tiesību subjektu tiesībām un pienākumiem mantojuma lietā. Darbā autore, aplūkojot katru mantojuma lietas posmu, sākot no mantojuma atklāšanās līdz tiesību pārņēmēju noskaidrošanai vai mantojuma lietas izbeigšanai, ir analizējusi problemātikas rašanās pamatus un darba noslēgumā sniegusi priekšlikumus, kā risināt aplūkotos problemātikas gadījumus.
Targeting a Targeted Drug: An Approach Toward Hypoxia-Activatable Tyrosine Kinase Inhibitor Prodrugs
2016
Tyrosine kinase inhibitors (TKIs), which have revolutionized cancer therapy over the past 15 years, are limited in their clinical application due to serious side effects. Therefore, we converted two approved TKIs (sunitinib and erlotinib) into 2-nitroimidazole-based hypoxia-activatable prodrugs. Kinetics studies showed very different stabilities over 24 h; however, fast reductive activation via E. coli nitroreductase could be confirmed for both panels. The anticancer activity and signaling inhibition of the compounds against various human cancer cell lines were evaluated in cell culture. These data, together with molecular docking simulations, revealed distinct differences in the impact of …
Development and biological investigations of hypoxia-sensitive prodrugs of the tyrosine kinase inhibitor crizotinib
2019
Despite the huge success of tyrosine kinase inhibitors as anticancer agents, severe side effects are a major problem. In order to overcome this drawback, the first hypoxia-activatable 2-nitroimidazole-based prodrugs of the clinically approved ALK and c-MET inhibitor crizotinib were developed. The 2-aminopyridine functionality of crizotinib (essential for target kinase binding) was considered as ideal position for prodrug derivatization. Consequently, two different prodrugs were synthesized with the nitroimidazole unit attached to crizotinib either via carbamoylation (A) or alkylation (B) of the 2-aminopyridine moiety. The successful prodrug design could be proven by docking studies and a dr…
Precursors of bipolar disorders: A systematic literature review of prospective studies
2015
Objective To evaluate the presence of affective signs and symptoms as precursors of bipolar disorder in prospective studies, including assessment of their prevalence, duration, and predictive value. Data sources We followed PRISMA guidelines to search PubMed, CINAHL, PsycINFO, EMBASE, SCOPUS, and ISI Web of Science databases to May 31, 2013, using the terms bipolar disorder AND (antecedent* OR predict* OR prodrom* OR prospect*) AND (diagnosis OR development). Hand searching of identified reports led to additional relevant references. Study selection We included only English-language articles containing (1) prospective, longitudinal studies with at least 2 structured clinical assessments (in…
Clinical risk factors for bipolar disorders: A systematic review of prospective studies
2014
Background: Early phases and suspected precursor states of bipolar disorder are not well characterized. We evaluate the prevalence, duration, clinical features and predictive value of non-affective psychopathology as clinical risk factors for bipolar disorder in prospective studies. Methods: We screened PubMed, CINAHL, PsycINFO, Embase, SCOPUS, and ISI-Web of Science databases from inception up to January 31, 2014, following PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and searched: bipolar disorder AND [antecedentn OR predictn OR prodromn OR prospectn OR riskn] AND [diagnosis OR development]. We included only English language reports on prospective…
Zoledronate, ibandronate and clodronate enhance osteoblast differentiation in a dose dependent manner – A quantitative in vitro gene expression analy…
2010
Bisphosphonates are widely used in the clinical treatment of bone diseases with increased bone resorption. In terms of side effects, they are known to be associated with osteonecrosis of the jaw (BONJ). There are two groups of bisphosphonates: the nitrogen-containing bisphosphonates, e.g. zoledronate and ibandronate, and the non-nitrogen-containing bisphosphonates, e.g. clodronate. Their impact on bone metabolism seems to differ. The objective of this study was to compare the osteogenic differentiation potency of these two pharmacologic groups. Human osteoblasts were stimulated with zoledronate and ibandronate at concentrations of 5×10(-5) M, 5×10(-6) M and 5×10(-7) M over the experimental …
La televisión de la sociedad democrática: ¿Una necesidad imposible?
2004
Melodrammatici e risorgimentali: "I briganti" visti da Parigi
2022
L'articolo si concentra sull'opera di Saverio Mercadante e Jacopo Crescini "I briganti" (Parigi, Théâtre-Italien, 1836), e indaga, in una prospettiva storiografica culturale e ricostruttiva, i suoi significati melodrammatici e risorgimentali. The article focuses on the opera of Saverio Mercadante and Jacopo Crescini "I briganti" (Paris, Théâtre-Italien, 1836), and investigates, in a cultural and reconstructive historiographical perspective, its melodramatic and risorgimental meanings.
“The (anti-)establishment blues”: la doppia geografia di Sixto Rodriguez tra marginalità e sovversione
2016
The life and career of Sixto Rodríguez, the American folk-singer born in Detroit in 1942, weave together two different places. On the one hand, we find Detroit where at the turn of the Sixties Rodríguez recorded two albums without success. On the other, there is Cape Town where unknown to Rodríguez his music became very influential and its subversive contents found an unexpected space of resonance. This paper aims at investigating the double geography emerging from this astonishing musical biography. The analysis will focus on the complex relationship between musical practices and spatial formations, examining how power geometries shape and carve the field of their mutual production. If the…
Supervizoru atbalsta sistēmas nepieciešamība māsu klīnisko prakšu izglītības procesā
2020
Maģistra darbā ir pētīta tēma “Supervizoru atbalsta sistēmas nepieciešamība māsu klīnisko prakšu izglītības procesā”. Supervīzija un supervizors māszinību specialitātē tiek interpretēta kā mācīšanās un profesionālā atbalsta sistēma, kas ietver neskaitāmas darbības un sniedz iespēju attīstīt un pilnveidot kompetenci, uzņemties atbildību par savu profesionālo praksi, kā arī uzlabot sniegto pakalpojumu kvalitāti un drošību. Māszinību specialitātē supervīziju saista tieši ar klīnisko un mācību supervīziju, kuras mērķis ir uzlabot jau esošās un attīstīt jaunās zināšanas, prasmes un profesionālās kompetences saistībā ar aprūpes procesu un pievērst lielāku uzmanību māsas – studenta un māsas – paci…