Search results for "ODR"
showing 10 items of 434 documents
Handbuch für Organisten Bernharda Kothego (1821-1897)
2018
A particular favourite amongst the numerous 19th century „manuals for organists” was the Handbuch für Organisten, which was published for the first time in 1871 by Leuckart in Leipzig. Its author was Bernhard Kothe, a famous Silesian organist, conductor, composer, teacher, publicist, editor and an organiser of musical life. The Handbuch is a handy volume destined mainly for liturgical use. The collection comprises 346 smaller pieces of organ music, 46 modulation samples as well as an additional compilation of 18 easy preludes in the most frequently used ranges. The works are sorted in order of pitch (24 ranges) and, within the different ranges, in order of size. The shortest pieces were mea…
Photoactivation of Anticancer Ru Complexes in Deep Tissue: How Deep Can We Go?
2017
Activation of anticancer therapeutics such as ruthenium (Ru) complexes is currently a topic of intense investigation. The success of phototherapy relies on photoactivation of therapeutics after the light passes through skin and tissue. In this paper, the photoactivation of anticancer Ru complexes with 671-nm red light through tissue of different thicknesses was studied. Four photoactivatable Ru complexes with different absorption wavelengths were synthesized. Two of them (Ru3 and Ru4) were responsive to wavelengths in the “therapeutic window” (650–900 nm) and could be activated using 671-nm red light after passing through tissue up to 16-mm-thick. The other two (Ru1 and Ru2) could not be ac…
Antitumoural properties of benzannelated seven-membered 5-fluorouracil derivatives and related open analogues. Molecular markers for apoptosis and ce…
2005
Attention is increasingly being focussed on the cell cycle and apoptosis as potential targets for therapeutic intervention in cancer. We prepared a series of bioisosteric benzannelated seven-membered 5-FU O,N-acetals to test them against the MCF-7 human breast cancer cell line. Benzo-fused seven-membered O,O-acetals or their acyclic analogues led to the expected 5-FU O,N-acetals (or aminals), in addition to six- and 14-membered aminal structures and acyclic compounds. All the cyclic aminals provoked a G0/G1-phase cell cycle arrest, whereas Ftorafur, a known prodrug of 5-FU, and 1-[2-(2-hydroxymethyl-4-nitrophenoxy)-1-methoxyethyl]-5-fluorouracil (11) induced an S-phase cell cycle arrest. Al…
ChemInform Abstract: Synthesis and in vitro Studies on a Potential Dopamine Prodrug.
2009
Dopamine delivery to the central nervous system (CNS) undergoes the permeability limitations of blood-brain barrier (BBB) which is a selective interface that excludes most water-soluble molecules from entering the brain. Neutral amino acids permeate the BBB by specific transport systems. Condensation of dopamine with neutral amino acids could afford potential prodrugs able to interact with the BBB endogenous transporters and easily enter the brain. The synthesis and characterization of the dopamine derivative 2-amino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-phenyl-propionamide (7) is described. The chemical and enzymatic stability of 7 was evaluated. The molecular weight (300 Da) and Log Papp (…
Polyaminoacid–doxorubicin prodrug micelles as highly selective therapeutics for targeted cancer therapy
2016
An amphiphilic copolymer carrying high-dose doxorubicin (21% on a weight basis), PHEA–EDA–P,C–Doxo, was prepared by coupling doxorubicin with a biocompatible polyaminoacid through a pH-sensitive spacer. Additional derivatization with 4-pentynoic acid endows it with self-assembling properties by means of π–π stacking. These micelles can be triggered to promptly release drug in lysosomes (∼40% in 12 h) through pH-dependent micelle hydrolysis after uptake. In vitro tests on co-cultures of cancer (MDA-MB 231) and normal (HB-2) breast cells proved that the conjugate was selectively internalized into the former rather than normal cells, exploiting the caveolae-dependent endocytosis pathway, expla…
Multistage rocket: integrational design of a prodrug-based siRNA delivery system with sequential release for enhanced antitumor efficacy.
2018
An integrated peptide-camptothecin prodrug (RSC) system was designed as a nano-sized multistage rocket for the efficient complexation and controlled sequential release of siRNA and anticancer drug under tumor-relevant reductive and esterase-enriched conditions, which facilitated the avoidance of negative interactions and maximized the synergistic effect.
o-Ethoxybenzamid-Mannichbasen als potentielle Prodrugs. o-Ethoxybenzamide Mannich Bases as Potential Prodrugs
1986
Toxicity of binary mixtures of Cu, Cr and As to the earthworm Eisenia andrei
2020
AbstractChromated copper arsenate (CCA) mixtures were used in the past for wood preservation, leading to large scale soil contamination. This study aimed at contributing to the risk assessment of CCA-contaminated soils by assessing the toxicity of binary mixtures of copper, chromium and arsenic to the earthworm Eisenia andrei in OECD artificial soil. Mixture effects were related to reference models of Concentration Addition (CA) and Independent Action (IA) using the MIXTOX model, with effects being related to total and available (H2O and 0.01 M CaCl2 extractable) concentrations in the soil. Since only in mixtures with arsenic dose-related mortality occurred (LC50 92.5 mg/kg dry soil), it wa…
Correspondencia de Gregorio Mayáns y Siscar con Ignacio Jordán Amo del Río y Miguel de Manuel Rodríguez (1771-1780)
1966
Correspondencia entre juristas españoles del siglo XVIII.
Claudie, un "rurodrame" de George Sand
2006
This article examines a theatrical work of George Sand, Claudie, performed the 11th January 1851 on the theatre of Porte Saint Martin in Paris. The analysis concentrates at first on the modalities of writing of this theatre, and secondly on the relation of the famous novelist with the dramatic art, for which she had a great passion but the processes of which she did never come out very well. Claudie was successful for the large audience but the critics were more cautious. The play, all the same, marks a renewal of theatrical art for which George Sand will be always a careful promoter.