Search results for "ODY"

Acclimation capacity and rate change through life in the zooplankton Daphnia

2020

When a change in the environment occurs, organisms can maintain an optimal phenotypic state via plastic, reversible changes to their phenotypes. These adjustments, when occurring within a generation, are described as the process of acclimation. While acclimation has been studied for more than half a century, global environmental change has stimulated renewed interest in quantifying variation in the rate and capacity with which this process occurs, particularly among ectothermic organisms. Yet, despite the likely ecological importance of acclimation capacity and rate, how these traits change throughout life among members of the same species is largely unstudied. Here we investigate these rel…

The Clinical Value of Autoantibodies in Rheumatoid Arthritis

2018

Rheumatoid arthritis (RA) is a highly heterogeneous syndrome in terms of clinical presentation, progression, and response to therapy. In such a complicated context, the identification of disease-related biomarkers would be undoubtedly helpful in assisting tailored approaches for every patient. Despite remarkable efforts, however, progress in new biomarker development and validation is dramatically slow. At present, none of the candidate genetic, cellular, or molecular biomarker has yet surpassed the clinical value of RA-specific autoantibodies, including rheumatoid factor (RF) and anti-citrullinated protein autoantibodies (ACPA). Rather, recent years have witnessed significant advancements …

FRI0030 Anti-TNF-α Antibody Targeted To Inflamed Synovial Tissue for The Treatment of Rheumatoid Arthritis

2016

Background TNF-α neutralizing molecules represent one of the most efficient therapeutic approaches to control inflammation in rheumatoid arthritis (RA). The widespread distribution in the body induces the inhibition of TNF-α in all the tissues, requesting the use of high dose of this expensive drug. Another problem that has not yet been solved in the management of RA patients is how to reduce and possibly avoid the side effects, particularly the increased risk of common and opportunistic infections, which may be associated with long-term administration of these therapeutic drugs. Objectives The aim of the present investigation was to show that a recombinant protein obtained by fusing a syno…

Cypriana Norwida słowo i druk

2009

Laboratory Measurements of Upstream Overdeepening

2000

Efficacy and safety of photodynamic therapy with RLP068 for diabetic foot ulcers: a review of the literature and clinical experience

2020

This article is the second part of a literature review concerning diabetic foot ulcers (DFUs) and the use of antimicrobial photodynamic therapy (PDT). PDT involves the topical application of a photosensitiser into the tissue, followed by illumination that induces the formation of reactive oxygen species (ROS). PDT provides bacterial inactivation and promotes wound healing, and it can be used to manage the infection and microbial colonisation of DFUs. It has pivotal advantages in comparison with chemotherapeutics, such as no potential to induce resistance, and a wide spectrum of activity. Tetracationic Zn(II) phthalocyanine derivatives have been developed for PDT. Among these, we would like …

Photoluminescent Detection of Human T-Lymphoblastic Cells by ZnO Nanorods.

2020

The precise detection of cancer cells currently remains a global challenge. One-dimensional (1D) semiconductor nanostructures (e.g., ZnO nanorods) have attracted attention due to their potential use in cancer biosensors. In the current study, it was demonstrated that the possibility of a photoluminescent detection of human leukemic T-cells by using a zinc oxide nanorods (ZnO NRs) platform. Monoclonal antibodies (MABs) anti-CD5 against a cluster of differentiation (CD) proteins on the pathologic cell surface have been used as a bioselective layer on the ZnO surface. The optimal concentration of the protein anti-CD5 to form an effective bioselective layer on the ZnO NRs surface was selected. …

Foot and Lower Limb Clinical and Structural Changes in Overuse Injured Recreational Runners Using Floating Heel Shoes: Preliminary Results of a Rando…

2021

Foot-strike and the associated load rate are factors related to overuse injuries in runners. The purpose of this study was to analyse structural and functional changes in runners using floating heel running shoes, compared with runners using conventional footwear. A randomised control trial was conducted. Twenty runners with overuse injuries were followed over a 12-week gait retraining programme using floating heel running shoes or their conventional footwear. Pain was measured with pressure pain thresholds (PPTs), structural changes were measured with ultrasonography, and severity and impact of injury was scored on the Oslo Sports Trauma Research Centre Overuse Injury Questionnaire (OSTRC-…

Uttalet i läroböcker i svenska som andraspråk från begriplighetsperspektiv

2020

I denna artikel studerar jag hur uttal presenteras i finska gymnasieläroböcker (n=10) i svenska som andra språk. Syftet är att undersöka vilka uttalsdrag som tas upp i läroböckerna och relationen mellan dessa drag och begriplighet. Metoden som jag använder är kvalitativ innehållsanalys. Prosodiska drag har ansetts ha en stor betydelse för begriplighet. Vad det gäller svenska är speciellt satsrytm viktig. Analysen visar dock att uppmärksamheten oftast fästs vid enskilda segment (språkljud) och ord. Uttalet av hela satser övas också men regler eller anvisningar om produktionen av prosodiska drag presenteras bristfälligt. Att ange explicita råd och att göra inläraren medveten har i tidigare un…

"Laulu syömmet aukaisee" : kokonaisvaltainen laulunopetus musiikkiliikunnan avulla

2018

The subject of this research is a holistic approach to singing education using body movements. This study was conducted as action research in which the singing pedagogue also worked as a researcher. The aim of this study was to: develop an approach to singing education with body movements, qualitatively investigate how singing with body movements can be used in solo singing education and how pedagogical ideas of Finnish music and movement teacher Inkeri Simola-Isaksson could be adapted to singing education. The data included interviews of the vocal students at the University of Oulu and the vocal students of the Johann Sebastian Bach music school in Vienna, participant journals and research…