Search results for "OLFACTORY"
showing 10 items of 319 documents
Nuclear aggregation of olfactory receptor genes governs their monogenic expression.
2012
SummaryGene positioning and regulation of nuclear architecture are thought to influence gene expression. Here, we show that, in mouse olfactory neurons, silent olfactory receptor (OR) genes from different chromosomes converge in a small number of heterochromatic foci. These foci are OR exclusive and form in a cell-type-specific and differentiation-dependent manner. The aggregation of OR genes is developmentally synchronous with the downregulation of lamin b receptor (LBR) and can be reversed by ectopic expression of LBR in mature olfactory neurons. LBR-induced reorganization of nuclear architecture and disruption of OR aggregates perturbs the singularity of OR transcription and disrupts the…
Chemoresponsiveness and Breath Physiology in Anosmia
2014
Anosmia is a model to study the interaction among chemoreception systems. In the head injury, the traumatic irreversible anosmia caused by damage to olfactory nerve fibers and brain regions is of enviable research interest. In this study, psychophysiological tests for a comprehensive assessment of olfactory function were utilized to investigate anosmia, together with a new technique based on the breath real-time monitoring of volatile organic compounds (VOCs). We applied the breath and VOCs analysis to investigate chemoresponsiveness in the long-term irreversible post-traumatic anosmia.
When the nose must remain responsive: glutathione conjugation of the mammary pheromone in the newborn rabbit
2014
In insects, xenobiotic-metabolizing enzymes were demonstrated to regulate pheromones inactivation, clearing them from the olfactory periphery and keeping receptors ready for stimulation renewal. Here, we investigate whether similar processes could occur in mammals, focusing on the pheromonal communication between female rabbits and their newborns. Lactating rabbits emit in their milk a volatile aldehyde, 2-methylbut-2-enal, that elicits searching-grasping in neonates; called the mammary pheromone (MP), it is critical for pups which are constrained to find nipples within the 5 min of daily nursing. For newborns, it is thus essential to remain sensitive to this odorant during the whole nursin…
The "olfactostriatum" of snakes: a basal ganglia vomeronasal structure in tetrapods.
2005
The olfactostriatum is a portion of the basal ganglia of snakes situated ventromedially to the nucleus accumbens proper. It receives a major vomeronasal input from the nucleus sphericus, the primary target of accessory olfactory bulb efferents. Recently, the ophidian olfactostriatum has been characterized on the basis of chemoarchitecture (distribution of serotonin, neuropeptide Y and tyrosine hydroxylase) and hodology (afferent and efferent connections). In contrast to the nucleus accumbens proper, the olfactostriatum is densely immunoreactive for serotonin and neuropeptide Y and sparsely immunoreactive for tyrosine hydroxylase. The nucleus accumbens proper and the olfactostriatum share mo…
A new odorant-binding protein XlaeOBP identified in the aerial olfactory system of Xenopus laevis and Xenopus tropicalis
2004
National audience
3d ligandbased virtual screening for deorphanisation of a human olfactory receptor
2008
International audience
Modelling analysis of centroid curves of olfactory habituation in humans
2020
Indexation en cours.; International audience; Previously published experiments established the time-course of olfactory habituation in humans, and extracted 3 centroid curves from clustering analysis that reflected high, middle and low habituation. The aim of the current theoretical study was to further analyse these previous experimental data by developing a mathematical modelling analysis designed for fitting the 3 curves from a general equation. After adjusting equation parameters for each curve, fitting equation outcomes on experimental data yielded high correlation coefficients of 0.9997 – 0.9995 – 0.9962, respectively. A model-based interpretation of olfactory-habituation centroid cur…
Pyrethroids alter sodium channel gating in honeybee olfactory receptor neurons
2010
International audience; Social structure in a domestic honeybee colony relies on inter-individual. chemical communication. Chemical communication is mediated. by odors and pheromones detected by olfactory receptor. neurons (ORN) localized in antennae. The Colony Collapse Disorder. (CCD) has been described in many countries around the world. and one of its main symptoms is the desertion of the hive by adult. worker bees, leaving the queen with brood and a small number of. young bees only. Our hypothesis is that such a desertion could be a. consequence of a disruption in the colony cohesion due to a defective. peripheral olfactory system. Recent studies have shown that. several insecticides c…
Biotransformation of odorants modifies the olfactory signal
2009
International audience