Search results for "OLFACTORY"
showing 10 items of 319 documents
Are hedonic responses to food odours linked to food liking in infants at 12 and 22 months?
2013
Communication orale (résumé 1 p.) ; http://www.pangborn2013.com/; International audience
G-protein-coupled odorant receptors underlie mechanosensitivity in olfactory sensory neurons
2012
G-protein-coupled odorant receptors underlie mechanosensitivity in olfactory sensory neurons. 34. annual meeting - Association for chemoreception sciences (AChemS)
Impact of a maternal high fat high sucrose diet on progeny's olfactory system
2018
International audience
The human OR1G1 olfactory receptor is differentially activated by various sandalwood odorants. A joint approach combining in silico and in vitro expe…
2013
International audience; Sandalwood is a highly valuable component in perfumery. The action mode of sandalwood odorant molecules remains to be addressed. In fact, olfactory receptors involved in their perception have not yet been identified. The interaction of a human olfactory receptor, hOR1G1, with sandalwood odorants has been investigated. By means of cellular biology and functional tests experiments, we provide an additional insight to our atomic model of OR1G1 and our olfactophore approach performed on various odorants. The studied odorants cover a wide range of structures and sandalwood intensities. We experimentally show that beta-santalol is a strong agonist of hOR1G1, contrarily to …
Evidence of peripheral olfactory adaptation
2016
Mise en évidence de transporteurs de la résistance pléiotropique dans la muqueuse olfactive et leur implication dans la réponse aux odorants chez les…
2011
Multidrug resistance (MDR) is a property of various cells associated with the capacity to reject or efflux a wide range of potentially harmful substances out of the cell. Pumps that effect such efflux are membrane proteins and belong to the ATP- binding cassette (ABC) superfamily. Among the members of the ABC family two are conferring MDR, P-glycoprotein (Pgp) and the multidrug resistance-associated protein (MRP1). In this study we investigated the functional activity of MDR transporters in olfactory mucosa of two species, rat and mouse. We used the fluorometric calcein-AM uptake assay on olfactory mucosal slices incubated with specific inhibitors of the MDR-transporters, verapamil and cycl…
3D-QSAR study of ligands for two human olfactory receptors
2008
International audience; All living organisms, including human beings, are able to detect and discriminate myriads of structurally diverse odorants through their interaction with olfactory receptors (ORs) (1). It is well accepted that the perception of thousands of odors by about 380 ORs results from a combinatorial coding, in which one OR recognizes multiple odorants and different odorants are recognized by different combinations of ORs (2). In a previous study (3), the functional characterization on two human ORs, called OR1G1 (class II) and OR52D1 (class I) have been performed using 95 odorant molecules. We used these previously obtained functional data (3) to perform a molecular modellin…
Foetor judaicus: antisemitism and the excremental imagination in late nineteenth-century French-speaking novels
2021
This study examines the relationship between anti-Semitic discourse and excremental olfactory notations in French and Belgian fictional narratives during the second half of the nineteenth-century, including works from the Goncourt brothers, Rachilde, Léon Bloy, and Camille Lemonnier, among others. The novelists use nauseating olfactory notations, often linked to faecal matter, waste, digestion, etc., as clues of a character's ties with the Jewish community. The relationship between anti-Semitic ideology and excremental olfactory notations illustrates complex political, social, cultural, and economic tensions, directly influencing the ways in which literary texts conceive the discourses surr…
Cellular Composition and Organization of the Subventricular Zone and Rostral Migratory Stream in the Adult and Neonatal Common Marmoset Brain
2011
The adult subventricular zone (SVZ) of the lateral ventricle contains neural stem cells. In rodents, these cells generate neuroblasts that migrate as chains toward the olfactory bulb along the rostral migratory stream (RMS). The neural-stem-cell niche at the ventricular wall is conserved in various animal species, including primates. However, it is unclear how the SVZ and RMS organization in nonhuman primates relates to that of rodents and humans. Here we studied the SVZ and RMS of the adult and neonatal common marmoset (Callithrix jacchus), a New World primate used widely in neuroscience, by electron microscopy, and immunohistochemical detection of cell-type-specific markers. The marmoset …
2015
AbstractGenomic imprinting is implicated in the control of gene dosage in neurogenic niches. Here we address the importance of Igf2 imprinting for murine adult neurogenesis in the subventricular zone (SVZ) and in the subgranular zone (SGZ) of the hippocampus in vivo. In the SVZ, paracrine IGF2 is a cerebrospinal fluid and endothelial-derived neurogenic factor requiring biallelic expression, with mutants having reduced activation of the stem cell pool and impaired olfactory bulb neurogenesis. In contrast, Igf2 is imprinted in the hippocampus acting as an autocrine factor expressed in neural stem cells (NSCs) solely from the paternal allele. Conditional mutagenesis of Igf2 in blood vessels co…