Search results for "ONSET"

Effectiveness and safety of electrical cardioversion for acute-onset atrial fibrillation in the emergency department: a real-world 10-year single cen…

2019

OBJECTIVE Despite limited evidence, electrical cardioversion of acute-onset atrial fibrillation (AAF) is widely performed in the emergency department (ED). The aim of this study was to describe the effectiveness and safety of electrical cardioversion of AAF performed by emergency physicians in the ED. METHODS All episodes of AAF electrically cardioverted in the ED were retrieved from the database for a 10-year period. Most patients not already receiving anticoagulants were given enoxaparin before the procedure (259/419). Procedural complications were recorded, and the patients were followed-up for 30 days for cardiovascular and hemorrhagic complications. RESULTS Four hundred nineteen eligib…

Rapid onset opioids for breakthrough pain: Titrating or not titrating, this is the question!

2011

Abstract Breakthrough cancer pain (BTcP) has been defined as a transitory increase in pain intensity that occurs either spontaneously, or in relation to a specific predictable or unpredictable trigger, despite relatively stable and adequately controlled background pain. Traditional dosing recommendations for BTcP have suggested that the effective dose of oral opioids should be a percentage of a patient’s total daily opioid dose. In the last years a number of new formulations that deliver fentanyl directly through mucous membranes have been developed in an effort to provide a more rapid onset of effect (rapid onset opioids, ROOs). Recent recommendations suggest that the dose of ROOs for BTcP…

First-Episode Psychosis Patients Who Deteriorated in the Premorbid Period Do Not Have Higher Polygenic Risk Scores Than Others: A Cluster Analysis of…

2023

Abstract Cluster studies identified a subgroup of patients with psychosis whose premorbid adjustment deteriorates before the onset, which may reflect variation in genetic influence. However, other studies reported a complex relationship between distinctive patterns of cannabis use and cognitive and premorbid impairment that is worthy of consideration. We examined whether: (1) premorbid social functioning (PSF) and premorbid academic functioning (PAF) in childhood and adolescence and current intellectual quotient (IQ) define different clusters in 802 first-episode of psychosis (FEP) patients; resulting clusters vary in (2) polygenic risk scores (PRSs) for schizophrenia (SCZ_PRS), bipolar dis…

Circulating Levels of Ferritin, RDW, PTLs as Predictive Biomarkers of Postoperative Atrial Fibrillation Risk after Cardiac Surgery in Extracorporeal …

2022

Postoperative atrial fibrillation (POAF) is the most common arrhythmia after cardiac surgery in conventional extracorporeal circulation (CECC), with an incidence of 15–50%. The POAF pathophysiology is not known, and no blood biomarkers exist. However, an association between increased ferritin levels and increased AF risk, has been demonstrated. Based on such evidence, here, we evaluated the effectiveness of ferritin and other haematological parameters as POAF risk biomarkers in patients subjected to cardiac surgery. We enrolled 105 patients (mean age = 70.1 ± 7.1 years; 70 men and 35 females) with diverse heart pathologies and who were subjected to cardiothoracic surgery. Their blood sample…

Is There an Advantage to Venlafaxine in Comparison with Other Antidepressants?

1997

The purpose of this article is to compare and contrast the benefits and limitations of antidepressant drugs. Several different classes of antidepressants are available for treatment of major depressive disorder, each with its own benefits and limitations as a result of its pharmacological profile. Tricyclic antidepressants (TCAs) and monoamine oxidase (MAO) inhibitors are effective in a large proportion of depressed patients, but their use is often limited by short- and long-term safety/tolerability problems. Selective serotonin reuptake inhibitors (SSRIs) exhibit comparable efficacy to TCAs in most patients, but may be less effective in certain patients. Additionally, SSRI use may by impac…

Delayed onset muscle soreness (DOMS) management: present state of the art

2016

This paper reviews existing theories explaining the delayed onset muscle soreness (DOMS) phenomenon. The authors describe the main symptoms of DOMS and their relation to different kinds of training strategies, and discuss the most popular muscle pain reduction interventions such as stretching, diet, dietary supplements, nonsteroidal anti-inflammatory drugs (NSAIDs), cryotherapy and cold water immersion, concurrent training, and the repeated bout effect.

Effect of tempo and vision on interpersonal coordination of timing in dyadic performance

2015

Interpersonal coordination within a dyadic musical performance requires that the two musicians share a similar mental model of the music’s timing structure. In addition to non-fluctuating inter-onset-interval, matched mental models can be observed through corporeal articulations and apparent embodiment of musical features (i.e. synchronous body sway, mimicked or complementary gestures). Our aim was to examine the effect of tempo on interpersonal coordination within a musical dyad. Violin dyads performed three unfamiliar collaborative musical sequences in facing vs. non-facing conditions. Our hypotheses were that interpersonal coordination would be weakened in the non-facing conditions, and …

Diferencias de género entre autocultivadores de cannabis en España

2019

The increase in cannabis use coincides with the proliferation of small-scale cannabis cultivation. These crops facilitate substance availability and increased use. Some investigations have studied the characteristics of small-scale cultivators; however, it is not known whether their profiles differ by gender. The aim of the present study was to analyse differences among growers regarding sociodemographic variables, patterns of use and health problems from a gender perspective. A descriptive observational study was designed with a sample of 219 cultivators (157 men and 62 women), aged between 18 and 34. Problematic use of cannabis (CPQ), cannabis dependence (SDS), patterns of abuse (CAST), r…

Overwintering strategies of a boreal small mammal in a changing climate

2015

Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consorti…

2016

Myopia, currently at epidemic levels in East Asia, is a leading cause of untreatable visual impairment. Genome-wide association studies (GWAS) in adults have identified 39 loci associated with refractive error and myopia. Here, the age-of-onset of association between genetic variants at these 39 loci and refractive error was investigated in 5200 children assessed longitudinally across ages 7–15 years, along with gene-environment interactions involving the major environmental risk-factors, nearwork and time outdoors. Specific variants could be categorized as showing evidence of: (a) early-onset effects remaining stable through childhood, (b) early-onset effects that progressed further with i…