Search results for "OPG"

showing 10 items of 12 documents

The Role of Osteoprotegerin and Its Ligands in Vascular Function

2019

International audience; The superfamily of tumor necrosis factor (TNF) receptors includes osteoprotegerin (OPG) and its ligands, which are receptor activators of nuclear factor kappa-B ligand (RANKL) and TNF-related apoptosis-inducing ligand (TRAIL). The OPG/RANKL/RANK system plays an active role in pathological angiogenesis and inflammation as well as cell survival. It has been demonstrated that there is crosstalk between endothelial cells and osteoblasts during osteogenesis, thus establishing a connection between angiogenesis and osteogenesis. This OPG/RANKL/RANK/TRAIL system acts on specific cell surface receptors, which are then able to transmit their signals to other intracellular comp…

0301 basic medicineAngiogenesismedicine.medical_treatmentReview030204 cardiovascular system & hematologyLigandslcsh:ChemistryTNF-Related Apoptosis-Inducing Ligand0302 clinical medicineReceptorlcsh:QH301-705.5Cellular SenescenceSpectroscopyReceptor Activator of Nuclear Factor-kappa BbiologyChemistryvascular diseaseGeneral MedicineComputer Science ApplicationsProtein Transportmedicine.anatomical_structureCytokineRANKLTumor necrosis factor alphaDisease Susceptibilitymedicine.symptomProtein BindingSignal Transductionmusculoskeletal diseasesProteasome Endopeptidase ComplexEndotheliumendotheliumNeovascularization PhysiologicInflammationCatalysisInorganic ChemistryStructure-Activity Relationship03 medical and health sciencesOsteoprotegerin[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemmedicineAnimalsHumansPhysical and Theoretical ChemistryMolecular BiologyMyocardiumRANK LigandOrganic ChemistryEndothelial Cells030104 developmental biologylcsh:Biology (General)lcsh:QD1-999osteoprotegerinOPG/RANKL/RANKCancer researchbiology.proteinBlood VesselsBiomarkers
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Cabozantinib targets bone microenvironment modulating human osteoclast and osteoblast functions

2016

Cabozantinib, a c-MET and vascular endothelial growth factor receptor 2 inhibitor, demonstrated to prolong progression free survival and improve skeletal disease-related endpoints in castration-resistant prostate cancer and in metastatic renal carcinoma. Our purpose is to investigate the direct effect of cabozantinib on bone microenvironment using a total human model of primary osteoclasts and osteoblasts.Osteoclasts were differentiated from monocytes isolated from healthy donors; osteoblasts were derived from human mesenchymal stem cells obtained from bone fragments of orthopedic surgery patients. Osteoclast activity was evaluated by tartrate resistant acid phosphatase (TRAP) staining and …

0301 basic medicinePyridines -- pharmacologyPyridinesPyridineImmunoenzyme TechniqueOsteoclastsApoptosisRANK Ligand -- genetics -- metabolismImmunoenzyme Techniqueschemistry.chemical_compoundBone Resorption -- drug therapy -- metabolism -- pathology0302 clinical medicineOsteogenesisCathepsin KMedicineAnilidesAnilides -- pharmacologyOsteoprotegerin -- genetics -- metabolismOsteoclasts -- cytology -- drug effects -- physiologyHuman primary cellCells CulturedTartrate-resistant acid phosphataseReceptor Activator of Nuclear Factor-kappa B -- genetics -- metabolismbiologyProto-Oncogene Proteins c-met -- genetics -- metabolismReceptor Activator of Nuclear Factor-kappa BReverse Transcriptase Polymerase Chain ReactionOsteoblastOsteogenesiOsteoblastCell DifferentiationSciences bio-médicales et agricolesProto-Oncogene Proteins c-metOsteoblasts -- cytology -- drug effects -- physiologymedicine.anatomical_structureCell Differentiation -- drug effectsOncologyRANKL030220 oncology & carcinogenesishuman primary cellsOsteoclastosteoprotegerin (OPG)bone microenvironmentHumanResearch Papermusculoskeletal diseasesmedicine.medical_specialtyCabozantinibBlotting WesternOsteogenesis -- drug effects -- physiologyReal-Time Polymerase Chain ReactionBone resorption03 medical and health sciencesOsteoprotegerinOsteoclastcabozantinibInternal medicineHumansRNA MessengerBone ResorptionCell ProliferationOsteoblastsbusiness.industryRANK LigandAnilideOsteoprotegerinApoptosiBone microenvironment; Cabozantinib; Human primary cells; Osteoprotegerin (OPG); Receptor activator of nuclear factor-kb ligand (RANKL); Anilides; Apoptosis; Blotting Western; Bone Resorption; Cell Differentiation; Cell Proliferation; Cells Cultured; Humans; Immunoenzyme Techniques; Osteoblasts; Osteoclasts; Osteogenesis; Osteoprotegerin; Proto-Oncogene Proteins c-met; Pyridines; RANK Ligand; RNA Messenger; Real-Time Polymerase Chain Reaction; Receptor Activator of Nuclear Factor-kappa B; Reverse Transcriptase Polymerase Chain Reaction; Oncology030104 developmental biologyEndocrinologychemistrybiology.proteinbusinessRNA Messenger -- geneticsreceptor activator of nuclear factor-kb ligand (RANKL)
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Inhibition of miR-21 restores RANKL/OPG ratio in multiple myeloma-derived bone marrow stromal cells and impairs the resorbing activity of mature oste…

2015

// Maria Rita Pitari 1 , Marco Rossi 1 , Nicola Amodio 1 , Cirino Botta 1 , Eugenio Morelli 1 , Cinzia Federico 1 , Annamaria Gulla 1 , Daniele Caracciolo 1 , Maria Teresa Di Martino 1 , Mariamena Arbitrio 2 , Antonio Giordano 3, 4 , Pierosandro Tagliaferri 1 , Pierfrancesco Tassone 1, 4 1 Department of Experimental and Clinical Medicine and T. Campanella Cancer Center, Magna Graecia University, S. Venuta University Campus, Catanzaro, Italy 2 ISN-CNR, Roccelletta di Borgia, Catanzaro, Italy 3 Department of Human Pathology and Oncology, University of Siena, Siena, Italy 4 Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology,…

Bone diseaseMessengerOsteoclastsTumor Microenvironment3' Untranslated RegionsMultiple myelomaTumorbiologyMesenchymal Stromal CellsRANKLProtein Inhibitors of Activated STATUp-Regulationmedicine.anatomical_structureOncologyRANKLmiRNAsmiR-21MiRNAMultiple MyelomaMiR-21; MiRNAs; Multiple myeloma bone disease; OPG; RANKL; 3' Untranslated Regions; Bone Marrow Cells; Bone Resorption; Cell Adhesion; Cell Line Tumor; Coculture Techniques; HEK293 Cells; Humans; Interleukin-6; Lentivirus; Mesenchymal Stromal Cells; MicroRNAs; Molecular Chaperones; Multiple Myeloma; Osteoclasts; Osteoprotegerin; Protein Inhibitors of Activated STAT; RANK Ligand; RNA Messenger; STAT3 Transcription Factor; Stromal Cells; Tumor Microenvironment; Up-Regulation; OncologyResearch Papermusculoskeletal diseasesSTAT3 Transcription FactorStromal cellBone Marrow CellsBone resorptionCell LineOsteoprotegerinCell Line TumormedicineCell AdhesionHumansRNA MessengerBone Resorptionbusiness.industryInterleukin-6LentivirusRANK LigandOsteoprotegerinMesenchymal Stem Cellsmedicine.diseaseMolecular medicineCoculture TechniquesMicroRNAsmultiple myeloma bone diseaseHEK293 CellsImmunologyCancer researchbiology.proteinRNAOPGBone marrowStromal CellsbusinessMolecular ChaperonesOncotarget
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Role of OPG-RANK-RANKL pathway in the pathophysiology, diagnosis and therapeutic follow-up of metastatic bone disease.

2011

Settore MED/06 - Oncologia MedicaRole of OPG-RANK-RANKLpathophysiology diagnosis and therapeutic follow-upmetastatic bone disease.
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La Ortopantomografía como método para la detección de las placas de ateroma calcificadas: Revisión de la literatura

2006

Los accidentes cerebrovasculares (ACV) constituyen la tercera causa de muerte en los países industrializados, tras la cardiopatía isquémica y el cáncer. Se trata pues de un importante problema de Salud pública, no sólo por su elevada incidencia, sino también por el alto costo que genera la rehabilitación física y psicológica de estos pacientes. El Odontoestomatólogo, como profesional de la salud, debe implicarse ante esta situación y contribuir, dentro de sus posibilidades, a la detección precoz de los pacientes con riesgo de sufrir un ACV. Desde la década de los ochenta, distintos autores han descrito la posibilidad de detectar las placas de ateroma calcificadas localizadas en la bifurcaci…

UNESCO::CIENCIAS MÉDICASOdontologíaortopantomografía (OPG)Accidente cerebrovascular (ACV):CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludplacas de ateroma
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Kartering & waardering van een steentijdvindplaats met resten uit het mesolithicum te Lier-Duwijck II (prov. Antwerpen, B)

2012

Deze bijdrage presenteert de resultaten van een prospectie- en waarderingsonderzoek te Lier-Duwijck II (prov. Antwerpen), ter hoogte van een locatie die gekenmerkt wordt door de aanwezigheid van (mesolithische) lithische artefacten en verkoolde ecofacten in zandlemige afzettingen. Het artikel bespreekt de resultaten van een veldverkenning, manuele boringen, een proefputtenonderzoek en een daaropvolgende kleinschalige opgraving van een cluster geassocieerd met een windvalstructuur.

[SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistoryopgraving[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and PrehistorymesolithicumHistory and ArchaeologyLierproefputtenWommersomkwartsietwindvalArchéologie[ SHS.ARCHEO ] Humanities and Social Sciences/Archaeology and Prehistoryboringenprov. Antwerpen (B)vuursteenDuwijck IIComputingMilieux_MISCELLANEOUS
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La Ortopantomografía como método para la detección de las placas de ateroma calcificadas: Revisión de la literatura

2006

Los accidentes cerebrovasculares (ACV) constituyen la tercera causa de muerte en los países industrializados, tras la cardiopatía isquémica y el cáncer. Se trata pues de un importante problema de Salud pública, no sólo por su elevada incidencia, sino también por el alto costo que genera la rehabilitación física y psicológica de estos pacientes. El Odontoestomatólogo, como profesional de la salud, debe implicarse ante esta situación y contribuir, dentro de sus posibilidades, a la detección precoz de los pacientes con riesgo de sufrir un ACV. Desde la década de los ochenta, distintos autores han descrito la posibilidad de detectar las placas de ateroma calcificadas localizadas en la bifurcaci…

atheroma plaquesUNESCO::CIENCIAS MÉDICASpanoramic radiographortopantomografía (OPG)Accidente cerebrovascular (ACV):CIENCIAS MÉDICAS [UNESCO]Cerebrovascular accident (CVA)placas de ateroma
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Characterization of Alternaria alternata Isolates from Tangerine Hybrids Affected by Brown Spot in Italy

2011

Alternaria brown spot, caused by Alternaria alternata, is the most important disease of tangerines and their hybrids worldwide, including Italy. The disease represents, for some susceptible citrus cultivar, a limiting factor in profitable cultivation. The results of the characterization of A. alternata isolates obtained from lesions on leaves and fruits of Fortune, Nova and Winola hybrids and Valencia sweet orange, collected in two groves located in Calabria and Sicily, is reported. An endopolygalacturonase gene (endoPG) was sequenced from five representative strains and a phylogenetic tree based on endoPG sequence data of Italian isolates and those of citrus associated Alternaria species d…

biologySettore AGR/12 - Patologia VegetaleendoPG geneHorticulturesmall-spored AlternariaAlternariabiology.organism_classificationAlternaria brown spotfAFLPBrown spottangerine pathotypeHorticulturePhylogeneticsBotanyCultivarPectinaseHybrid
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LA DIMENSIONE DELLA GENITORIALITÀ IN UN OSPEDALE PSICHIATRICO GIUDIZIARIO

2010

genitorialitàSettore M-PSI/07 - Psicologia DinamicaOPG
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Estudio clínico, radiográfico y plasmático de la osteonecrosis de los maxilares por bisfosfonatos en un grupo de183 pacientes

2016

Osteonecrosis of the jaw is a particular form of chronic osteomyelitis caused by bisphosphonates (BF) or by other pharmacological or anti-angiogenic drugs. The BF are potent drugs inhibitors of osteoclasts by exerting a strong interaction with these cells, producing a sharp decrease of bone resorption. Objectives: To analyse clinical and radiologic characteristics as well as differences in the plasma levels of the Activation Nuclear Kappa receptor ligand (RANKL) and of osteoprotegerin (OPG) in a group of patients with osteonecrosis and compared to healthy controls. In addition, within the Group of patients with osteonecrosis maxillary study if there is relationship between plasma levels of …

musculoskeletal diseasesBisfosfonatosRadiologíaOsteonecrosisRANKLOPGInterleuquinas
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