Search results for "ORL"
showing 10 items of 1863 documents
Simone Corleo e "La Filosofia"
2015
Simone Corleo fa parte della serie di autori che, nel corso del secolo XIX, ha contribuito all’inserimento della fi losofia prodotta nell’Ateneo di Palermo nel vasto e articolato panorama della cultura italiana ed europea. A questo proposito, scorrendo a ritroso l’indice di una virtuale storia del pensiero filosofico e scientifico, dovremmo richiamarci, oltre che alla tradizione della Scuola di Vincenzo Miceli prodotta a Monreale sul fi nire del secolo XVIII, ai contributi dati soprattutto da Salvatore Mancino e da Benedetto D’Acquisto. Mancino, dopo avere pubblicato i due volumi degli Elementi di fi losofi a nel 1835-36, aveva tenuto la cattedra di Metafisica e Logica nell’Università degli…
Presenting the Past: A Framework for Facilitating the Externalization and Articulation of User Activities in Desktop Environment
2006
Work processes are conducted in various contexts and they involve different tasks, interruptions, activities and actions. In all of these, tacit knowledge plays a part. Some part of that tacit knowledge can be externalized and articulated by continuously monitoring the users activities. Because the desktop environment is an integral part of almost any office work context, we chart the demands the unstructured and discontinuous nature of work puts on the management of desktop working context. We discuss possibilities to augment the users awareness of his/her desktop working environment by providing a context-aware application that can act as a map-like resource for the users past activiti…
The (controversial) role of the UNESCO WHL Management Plans in promoting sustainable tourism development
2012
This paper investigates the relationship between tourism and planning in UNESCO World Heritage List (WHL) sites. It concentrates on the relation between Management Plans (MPs) and other (local and regional) planning instruments and policies able to influence the promotion of sustainable and responsible development. This is explored through an examination of two important tourist locations in Sicily: Agrigento (the Valley of the Temples) and the Aeolian Islands, which have both been recognized as World Heritage Sites by UNESCO. The analysis of these case studies will point out the challenge of integrating different management and planning regimes. The paper shows how supranational policies o…
Reactome diagram viewer: data structures and strategies to boost performance
2017
Abstract Motivation Reactome is a free, open-source, open-data, curated and peer-reviewed knowledgebase of biomolecular pathways. For web-based pathway visualization, Reactome uses a custom pathway diagram viewer that has been evolved over the past years. Here, we present comprehensive enhancements in usability and performance based on extensive usability testing sessions and technology developments, aiming to optimize the viewer towards the needs of the community. Results The pathway diagram viewer version 3 achieves consistently better performance, loading and rendering of 97% of the diagrams in Reactome in less than 1 s. Combining the multi-layer html5 canvas strategy with a space partit…
Pervasive Displays Research: What's Next?
2019
Reports on the 7th ACM International Symposium on Pervasive Displays that took place from June 6-8 in Munich, Germany.
Population Pharmacokinetics of Palbociclib in aReal-World Situation
2021
Palbociclib is an oral cyclin-dependent kinase inhibitor that is used in combination with aromatase inhibitors in the treatment of postmenopausal women with metastatic breast cancer. Its metabolism profile is associated with an important interpatient variability. We performed a population pharmacokinetics study of palbociclib in women routinely followed in a cancer center. One hundred and fifty-one samples were analyzed. The sampling times after administration ranged from 0.9 to 75 h and the samples were taken between 1 and 21 days after the beginning of the palbociclib cycle. Palbociclib was determined using a validated mass spectrometry method. The best model that described the concentrat…
Pharmacokinetics of new oral anticoagulants: implications for use in routine care
2018
Introduction: Since 2008, new oral anticoagulants (NOACs) have been approved for the prevention of venous thromboembolism (VTE) in patients receiving hip or knee replacement surgery, prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation (NVAF), treatment of deep vein thrombosis (DVT), and pulmonary embolism (PE). Premarketing randomized clinical trials (RCTs) of NOACs demonstrated their non-inferiority in terms of efficacy vs. warfarin (traditional oral anticoagulant–TOA), with lower risk of serious adverse drug reactions, especially cerebral hemorrhages. In clinical practice, pharmacokinetic aspects of NOACs have to be carefully taken into account to …
Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants
2016
Background One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the agestandardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are aff ecting the number of adults with diabetes. Methods We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence—defi ned as fasting plasma glucose of 7·0 mmol/L or higher, or history of diagnosis …
Agreements regarding the property relations of transnational couples and their effects under the application of the twin regulations
2021
It is a true and verifiable fact that the family institution has evolved over recent decades in Europe and throughout the world, but not uniformly or at the same time. This is because it is influenced by social and cultural connotations specific to each State. All of which are respected under EU Regulations 2016/1103 and 2016/1104. This work analyses the Twins Regulations, that gives the couples the possibility of choosing the jurisdiction (art. 7) and applicable legal system underpinning the property consequences of the marriage and registered partnerships (art. 22.1). However, we try to show you these rules absolute freedom of choice is not granted to the parties, because this freedom is …
The Adaptation of a Web Information System: A Perspective of Organizations
2011
We provide a different view on the problem of Web Information System (WIS) adaptation, looking from perspective of organizations that are interested in an adapted Web Information System for their needs if a unified system to support similar business processes is used. We propose an adaptation architecture for WIS. Two levels of adaptation are introduced—coarse grained adaptation for the organization level and fine grained adaptation for the user level. The architecture supports also the situation, when users can work with many instances of the system adapted for different organizations, which are integrated into one instance for a particular user.