Search results for "OSP"
showing 10 items of 25966 documents
W sprawie potrzeby uregulowania umowy franczyzy w Polsce
2021
Praca prezentuje w pierwszej kolejności zagadnienia związane z pojęciem umowy franczyzy jako empirycznym typem umowy, jak i teoretyczne zagadnienie problematyki umów nienazwanych. W kontekście treści stosunku prawnego franczyzy zwrócono uwagę na dwie kwestie. Po pierwsze, pomimo braku regulacji umowy franczyzy w polskim prawie cywilnym wpływ na treść stosunku prawnego franczyzy mają przepisy prawa publicznego z zakresu ochrony konkurencji (prawa antymonopolowego). Wpływ ten należy ocenić jako istotny. Ewentualne uregulowanie w prawie cywilnym umowy franczyzy nie będzie oznaczało dopuszczalności pominięcia przy nadawaniu jej konkretnej treści regulacji prawa ochrony konkurencji. Po drugie, t…
EUROsceptycyzm - propozycja konceptualizacji
2015
Autorzy niniejszego tekstu stawiają sobie za cel doprecyzowanie kategorii EUROsceptycyzmu. Artykuł rozpoczyna przegląd literatury w zakresie szerszej koncepcji eurosceptycyzmu, aby następnie pozycjonować w tym kontekście poglądy sceptyczne wobec unii walutowej w Europie. Punkt ciężkości opracowania kładzie się na przedmiotowym zakresie pojęcia EUROsceptycyzmu. Autorzy wskazują wymieniane w literaturze czynniki warunkujące zjawisko EUROsceptycyzmu, grupując je w trzy zestawy determinant. Do nich, jako ważną zmienną warunkującą narastanie EUROsceptycyzmu, dodają kryzys gospodarczy (2007–2014). Rozważania kończy podsumowanie wskazujące na obecny poziom EUROsceptycyzmu w Unii Europejskiej i pra…
Real-world experience with obeticholic acid in patients with primary biliary cholangitis
2021
Background & aims Obeticholic acid (OCA) is the second-line treatment approved for patients with primary biliary cholangitis (PBC) and an inadequate response or intolerance to ursodeoxycholic acid. We aimed to evaluate the effectiveness and safety of OCA under real-world conditions. Methods Patients were recruited into the Italian PBC Registry, a multicentre, observational cohort study that monitors patients with PBC at national level. The primary endpoint was the biochemical response according to Poise criteria; the secondary endpoint was the biochemical response according to normal range criteria, defined as normal levels of bilirubin, alkaline phosphatase (ALP), and alanine aminotransfer…
Alteration-Induced Volcano Instability at La Soufrière de Guadeloupe (Eastern Caribbean)
2021
International audience; Volcanoes are unstable structures that deform laterally and frequently experience mass wasting events. Hydrothermal alteration is often invoked as a mechanism that contributes significantly to volcano instability. We present a study that combines laboratory experiments, geophysical data, and large-scale numerical modeling to better understand the influence of alteration on volcano stability, using La Soufrière de Guadeloupe (Eastern Caribbean) as a case study. Laboratory experiments on variably altered (advanced argillic alteration) blocks show that uniaxial compressive strength, Young's modulus, and cohesion decrease as a function of increasing alteration, but that …
Estetica urbana. Atmosfere e artificazione degli spazi della città
2023
Ancora uno studio su questo argomento, infatti i pochi saggi su temi analoghi non adottano una prospettiva filosofica. Il volume mira a colmare questa lacuna affrontando l’estetica urbana attraverso due paradigmi interpretativi, che talvolta nel libro vengono intrecciati: i concetti di atmosfera e di artificazione. La nozione di “atmosfera” nasce in seno alla nuova fenomenologia tedesca di Hermann Schmitz ed è declinata verso l’estetica dal filosofo Gernot Böhme che la considera un paradigma privilegiato per indagare gli spazi emozionali, intesi come frutto di relazioni affettive tra il soggetto percipiente e l’oggetto percepito. Pertanto l’estetica delle atmosfere si rivela uno strumento t…
More nature in the city
2020
According to projects and practices that the Italian botanists and ecologists are carrying out for bringing “more nature in the city”, new insights for a factual integration between ecological perspectives and more consolidated aesthetic and agronomic approaches to the sustainable planning and management of urban green areas are provided.
La città ospedale e il sistema Policlinico-Civico di Palermo
2009
Studi, ricerche e riflessioni sulla progettazione di ospedali di grandi dimensioni
Nuorten urheilijoiden alaraajavammat ja riskitekijät : 12 kuukauden prospektiivinen kohorttitutkimus
2013
Tämän tutkimuksen tarkoituksena oli selvittää alaraajojen nivelten liikkuvuuden ja puolierojen yhteyttä alaraajojen urheiluvammoihin. Koehenkilöt olivat Tampereen alueelta 2011 kirjallisella kutsulla vapaaehtoisesti tutkimukseen osallistuvia kansallisella ja kansainvälisellä huipputasolla salibandyä, koripalloa ja jääkiekkoa pelaavia urheilijoita. (n=141, 114 naista, 27 miestä). Tutkimus oli osa UKK-instituutin ”Polvi- ja nilkkavammoja ennustavat tekijät sekä vammojen ehkäisy nuorilla urheilijoilla”–tutkimusta. Alaraajojen liikkuvuutta ja puolieroja mitattiin seitsemän eri testin avulla (polven laksiteetti ja yliojennus, nivelten yleinen yliliikkuvuus, takareiden elastisuus, lonkan maksimaa…
Players with high physical fitness are at greater risk of injury in youth football.
2022
The aim of this study was to investigate physical fitness, football-specific skills and their association with injury risk in youth football. Altogether 447 male and female players aged 9 to 14 years (median 12 years) participated in performance tests and prospective follow-up. The physical fitness tests included five-jump test for distance, 30-m sprint, football-specific figure of eight agility, countermovement jump, and Yo-Yo intermittent endurance test level 1. The football-specific skill tests included dribbling and passing tests. Injuries and exposure were registered during the 20-week follow-up. Our candidate risk factors were low/high level of physical fitness measured with a composi…
Properties of transmembrane helix TM1 of the DcuS sensor kinase of Escherichia coli, the stator for TM2 piston signaling
2021
Abstract The sensor kinase DcuS of Escherichia coli perceives extracellular fumarate by a periplasmic PASP sensor domain. Transmembrane (TM) helix TM2, present as TM2-TM2′ homo-dimer, transmits fumarate activation in a piston-slide across the membrane. The second TM helix of DcuS, TM1, is known to lack piston movement. Structural and functional properties of TM1 were analyzed. Oxidative Cys-crosslinking (CL) revealed homo-dimerization of TM1 over the complete membrane, but only the central part showed α-helical +3/+4 spacing of the CL maxima. The GALLEX bacterial two-hybrid system indicates TM1/TM1′ interaction, and the presence of a TM1-TM1′ homo-dimer is suggested. The peripheral TM1 regi…