Search results for "OSiS"
showing 10 items of 15931 documents
Applied genomics for tuberculosis diagnosis and surveillance
2020
La tuberculosis es una de las principales causas de muerte a nivel mundal. A lo largo de los ultimos años, la secuenciación de genoma comleto de Myobacterium tuberculosis, el agente infeccioso, se ha convertido en una herramienta extraordinaria en el estudio, diagnóstico y vigilancia epidemiológica de la enfermedad. Analizar el genoma completo de la bacteria permite la predicción precisa de resistencias a antibióticos, estudiar brotes con una resolución sin preecdentes, a la vez que permite estudiar la evolución y la diversidad genética del patógeno. Sin embargo el uso de la secuenciación genómica se ha visto dificultado por la dependencia de un proceso largo y costoso de cultivo microbiano…
Genomic epidemiology: from transmission to the evolution of pathogenic microorganisms
2022
La epidemiología genómica ha revolucionado el mundo microbiano. Sus aplicaciones permiten conocer y comprender mejor el comportamiento, la transmisión y la evolución de los microorganismos. A pesar de su gran y reconocido potencial, su uso aún es limitado, especialmente en regiones en desarrollo. El principal objetivo de esta tesis fue estudiar y analizar los genomas completos de tres microorganismos patógenos y zoonóticos para comprender mejor su epidemiología, potencial patogénico y evolución. En el primer capítulo caracterizamos a nivel genómico a Salmonella enterica aislada de alimentos, fincas y muestras clínicas en Ecuador. Además, presentamos evidencia de la presencia de factores de …
Estudio de la acción proinflamatoria de Angiotensina II y su posible modulación. Papel de Angiotensina II en disfunciones endoteliales.
2002
La acumulación leucocitaria es una característica de los primeros estadios de la lesión aterosclerótica, de infarto agudo de miocardio y de enfermedades renales de diversa etiología. Receptores para Angiotensina-II (Ang-II) han sido hallados en monocitos y Ang-II puede promover la activación y adhesión de estas células. Este proceso podría desencadenar o perpetuar el daño endotelial asociado a aterosclerosis e hipertensión. Los resultados de nuestro estudio demuestran que Ang-II, a dosis subvasoconstrictoras y fisiológicas, presenta propiedades proinflamatorias in vivo a nivel agudo; en concreto, produce acumulación leucocitaria en vénulas de la microcirculación mesentérica de la rata a tra…
Tuberculosis among Migrant Populations in Sicily: A Field Report
2021
Background. In the EU, tuberculosis (TB) mainly affects vulnerable people, including migrants. From 2014 to 2017, we have estimated the frequency of both tuberculosis and latent tuberculosis infection (LTBI) among the migrant population hosted in 41 reception centers in western Sicily (ITaCA network). Materials and Methods. All migrants were consecutively recruited for the screening of TB infection with physical examination and TST in 1,020 migrants and with IGRA in the others 2,690. The screening was carried out 4–8 weeks after landing in Sicily. For all migrants with a positive screening test, chest X-ray and smear examination were performed. LTBI was defined by positivity of TST or IGRA …
Oral contraceptives in the prevention of endometrioma recurrence: does the different progestins used make a difference?
2013
""The primary aim of the study was to analyze the endometrioma recurrence rate in patients who underwent laparoscopic excision followed by postoperative long-term regimen of oral contraceptives (OCs).. . MATERIALS AND METHODS: 168 patients who underwent a conservative laparoscopic surgery for endometrioma, during the period between September 2009 and August 2010 in three university hospitals were studied. A long-term OCs therapy was offered to all women following surgery. Patients were randomly divided into three groups according to different progestins used (desogestrel, gestodene, dienogest). Women who refused a postoperative hormonal therapy served as control. Follow-up visits and transv…
L’UTILIZZO IN MEDICINA LEGALE DELLA MISURAZIONEDELLA SALUTE DEL MINORE SECONDO ICF-CY: ESEMPLIFICA-ZIONE CASISTICA
2015
The evaluation of minors within welfare contest requires an adequate multidisciplinary and interdisciplinary approach to clinical and psycho-social order. There are many evaluation’s instruments, but in the medico legal context particularly useful is the evaluation according to the guidelines of the World Health Organization, in the recent codification ICF, International Classification of Functioning, Disability and Health [1] version YC (Children and Youth) [2]. The use of minor measurement according to ICF-CY is here reported in a child’s health experience with neuropsychiatric disorders. The system ICF-CY offers a revolutionary new model that relates biological, psychological and social …
Redescription of Chiropturopoda nidiphila Wiśniewski & Hirschmann (Acari: Uropodina) from a woodpecker’s tree holes, including all development stages…
2021
All development stages of Chiropturopoda nidiphila Wiśniewski & Hirschmann, 1983 are described, which has previously been known only from the deutonymph stage. The species is closely associated with tree holes excavated by woodpeckers. Chiropturopoda nidiphila was redescribed and the genus diagnosis was completed. The description of the species morphology is based largely on scanning (SEM) electronograms. Diagnoses differentiating all of the known species of the genus Chiropturopoda are provided, including their developmental stages.
Papel de la mitocondria en la neurodegeneración de las neuropatías periféricas
2014
La disfunción mitocondrial tiene severas consecuencias a nivel celular, y está íntimamente relacionada con el proceso de envejecimiento. Pero además, la mitocondria juega un importante papel en la muerte celular progresiva característica de algunos trastornos neurodegenerativos, de forma que la disfunción mitocondrial ha surgido como un denominador común en varias enfermedades neurodegenerativas. En la presente Tesis Doctoral nos hemos centrado en el estudio de los mecanismos patogénicos que conducen a la degeneración neuronal de dos neuropatías periféricas diferentes, pero relacionadas: ataxia de Friedreich (FRDA) y la enfermedad de Charcot-Marie-Tooth (CMT) tipos 4A/2K. Ambas enfermedades…
Frequency of Mitoxantrone related heart involvement in patients affected by Multiple Sclerosis
2010
Continuous subcutaneous Insulin infusion leads to immediate, table, and long-term changes in metabolic control
2008
Background: Evaluations of continuous subcutaneous insulin infusion (CSII) usually focus on one pre- and one post-CSII measurement to assess metabolic therapy outcome. Aim: Extending this research, the aim of the present study was to provide a more fine-grained analysis of achieved glycaemic control. Methods: In 52 patients with type 1 diabetes (mean age of 37.85 years at CSII begin; s.d. ± 12.41), haemoglobin A1c (HbA1c) levels were assessed every 3 months over a period of 5 years (1 year before and 4 years after the introduction of CSII). Mixed models were utilized to describe changes in glycaemic control. Results: The pre–post course showed that already in the first quarter, a statis…