Search results for "OSiS"
showing 10 items of 15931 documents
IAP proteins as targets for drug development in oncology.
2013
The inhibitors of apoptosis (IAPs) constitute a family of proteins involved in the regulation of various cellular processes, including cell death, immune and inflammatory responses, cell proliferation, cell differentiation, and cell motility. There is accumulating evidence supporting IAP-targeting in tumors: IAPs regulate various cellular processes that contribute to tumor development, such as cell death, cell proliferation, and cell migration; their expression is increased in a number of human tumor samples, and IAP overexpression has been correlated with tumor growth, and poor prognosis or low response to treatment; and IAP expression can be rapidly induced in response to chemotherapy or …
IAPs: more than just inhibitors of apoptosis proteins.
2008
Inhibitors of apoptosis proteins (IAPs) are a conserved family of proteins identified in species ranging from virus, yeasts, nematodes, fishes, flies and mammals. The common structural feature is the presence of at least one Baculovirus IAP Repeat (BIR) domain. Hence, IAPs are also known as BIR-containing proteins (BIRCs). Most of them display anti-apoptotic properties when overexpressed. In drosophila, IAPs are sufficient and necessary to promote cell survival through a direct regulation of apoptotic proteases called caspases. In mammals, BIRC4/XIAP, the most studied IAP member can directly inhibit the activity of caspase-3, 7 and 9. However, this activity is not conserved in other IAPs an…
Successful treatment of primary chronic osteomyelitis in SAPHO syndrome with bisphosphonates.
2008
Summary The treatment of the painful osteomyelitis in patients with SAPHO syndrome (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis) is often a problem. A 53-year-old woman had experienced palmo-plantar pustular skin lesions for four years, and in the past two years complained about progressive breath-and movement-dependent pain of the sternum. On examination she had extensive palmoplantar pustules and a painful swelling in the area of the right sternoclavicular joint. The three-phase bone scintigraphy showed a strong focal enrichment in the right sternoclavicular joint and at the transition from the manubrium to the corpus sterni suggesting active osteo-chondritis. Initially prednisolo…
Bio-silica and bio-polyphosphate: applications in biomedicine (bone formation)
2012
Bio-silica represents the main mineral component of the sponge skeletal elements (siliceous spicules), while bio-polyphosphate (bio-polyP), a multifunctional polymer existing in microorganisms and animals acts, among others, as reinforcement for pores in cell membranes. These natural inorganic bio-polymers, which can be readily prepared, either by recombinant enzymes (bio-silica and bio-polyP) or chemically (polyP), are promising materials/substances for the amelioration and/or treatment of human bone diseases and dysfunctions. It has been demonstrated that bio-silica causes in vitro a differential effect on the expression of the genes OPG and RANKL, encoding two mediators that control the …
Traditional and new types of spondarthritis with special consideration of spondylodiscitis
1990
In rheumatology the so-called "seronegative spondarthritis" is a group of diseases characterized by the presence of HLA-B 27. This group includes the typical ankylosing spondylitis as well as atypical spondylopathies such as those occurring in psoriasis, Reiter's disease and chronic inflammatory enteropathies, which attack mainly the spine and secondarily the peripheral joints. In some severe cases, non-infectious, sterile spondylodiscitis was observed. These can lead to instability and fracture, followed by pseudarthrosis of the involved segment of the spine. In contrast to these traditional spondarthritides three new types are marked by the lack of HLA-B 27. 1) "Spondarthritis hyperostoti…
An update on the relationships between rheumatoid arthritis and atherosclerosis
2010
Rheumatoid arthritis is a chronic inflammatory disease. Cardiovascular events are the most important cause of mortality and morbidity in patients with rheumatoid arthritis. Beyond the traditional cardiovascular risk factors, chronic systemic inflammation has been shown to be a crucial factor in atherosclerosis development and progression from endothelial dysfunction to plaque rupture and thrombosis. Many studies have shown that atherosclerosis is not a passive event like accumulation of lipids in the vessel walls; by contrast, it represents an active inflammation of the vessels. Inflammatory cells such as macrophages, monocytes and T cells play important roles in the development of both rhe…
Synovial chondromatosis of the temporomandibular joint
2007
La condromatosis sinovial (CS) es una enfermedad de etiología desconocida, la cual pude definirse como un proceso benigno sinovial caracterizado por la formación de nódulos cartilaginosos metaplásicos dentro del tejido conectivo de las superficies articulares, se le considera un fenómeno metaplásico activo más que un proceso neoplásico; presenta una marcada preferencia por afectar a mujeres constituyendo casi el 70% de los casos reportados, el rango de edad es amplio y oscila entre los 18 y 75 años con una media de 44.6 años. Dentro de los principales hallazgos clínicos destacan: sintomatología dolorosa, presencia de crepitación, aumento de volumen y limitación de la apertura bucal. La CS e…
Uso de la tomografía computarizada en el diagnóstico de la anquilosis de la articulación temporomandibular: Presentación de dos casos clínicos
2006
La anquilosis de la articulación temporomandibular es definida como la abolición o limitación de los movimientos de dicha articulación. Radiográficamente la anquilosis demuestra aspectos bien característicos que facilitan el diagnóstico, sin embargo, su análisis en las técnicas radiográficas convencionales, en la mayoría de las veces, no se presenta de forma clara. Con la evolución de las técnicas radiográficas, la tomografía computarizada pasó a ser un examen de gran importancia en el diagnóstico de las anquilosis temporomandibulares. En vista de ello, el presente trabajo se propone mostrar y describir imágenes tomográficas de la anquilosis de esta articulación, presentando dos casos clíni…
Condromatosis sinovial de la articulación temporomandibular: Estudio clínico, radiológico e histológico
2005
La condromatosis sinovial (CS) es una metaplasia cartilaginosa de los remanentes mesenquimales del tejido sinovial de las articulaciones. Se caracteriza por la formación de nódulos cartilaginosos en la sinovial y en la cavidad articular (cuerpos libres). La CS afecta sobre todo a grandes articulaciones sinoviales como la rodilla o el codo, siendo rara su aparición en la ATM, en donde tan solo 75 casos han sido publicados. Los síntomas predominantes son dolor, inflamación, limitación de los movimientos mandibulares y crepitación. Los métodos diagnósticos incluyen la ortopantomografía (OPG), la TC, la RM y la artroscopia de ATM. Presentamos un nuevo caso de CS unilateral de ATM, incluyendo la…
Zur Diagnostik der transitorischen Osteoporose der Hüfte und deren Darstellbarkeit in der MR-Tomographie
2008
Magnetic resonance (MR) imaging may distinguish transient osteoporosis of the hip from more severe hip diseases. 12 patients with transient osteoporosis of the hip underwent MR imaging. The initial and follow-up studies included T1- and T2-weighted images in coronal, transverse or sagittal planes. There were revealed 3 stages: diffuse-, focal-, and residual stage. This syndrome is characterized by hip pain, limping, and osteoporosis of the femoral head with preservation of the joint space. The clinical symptoms and abnormalities on MR images disappeared completely within 6-10 months.