Search results for "OSiS"
showing 10 items of 15931 documents
Assessment of the importance of physical activity and quality of life for patients diagnosed with osteoporosis during the COVID-19 pandemic
2021
Introduction. Osteoporosis is one of the most important ten diseases worldwide, still causing extreme suffering to patients and huge costs to the health system. The rapid increase of the population 's aging was involved in many aspects of human health, and, among these ones, osteoporosis was one of the main public health issues. The aim of the study was to assess the importance of physical activity and the quality of life in patients diagnosed with osteoporosis during the COVID-19 pandemic. Material and methods. The study is longitudinal, it was conducted in an outpatient setting for a period of 1 year and it included 20 patients diagnosed with osteoporosis. The demographic variables (age, …
La participación española en los programas de la OMS para el control de la rabia (1952-1975)
2017
S'analitza la participació espanyola en la investigació duta a terme per l'Organització Mundial de la Salut (OMS) per a obtenir un sèrum estàndard internacional contra la ràbia, en la qual va intervenir el laboratori del Servei de Virus de l'Escola Nacional de Sanitat de Madrid, així com la labor de Florencio Pérez Gallardo, director d'aquest, com a membre del Comité d'Experts de l'OMS sobre la ràbia. .//. Se analiza la participación española en la investigación llevada a cabo por la Organización Mundial de la Salud (OMS) para obtener un suero estándar internacional contra la rabia, en la que intervino el laboratorio del Servicio de Virus de la Escuela Nacional de Sanidad de Madrid, así com…
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
2011
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…
Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 ph…
2006
Aplidin® is an antitumor agent in phase II clinical trials that induces apoptosis through the sustained activation of Jun N-terminal kinase (JNK). We report that Aplidin® alters glutathione homeostasis increasing the ratio of oxidized to reduced forms (GSSG/GSH). Aplidin® generates reactive oxygen species and disrupts the mitochondrial membrane potential. Exogenous GSH inhibits these effects and also JNK activation and cell death. We found two mechanisms by which Aplidin® activates JNK: rapid activation of Rac1 small GTPase and downregulation of MKP-1 phosphatase. Rac1 activation was diminished by GSH and enhanced by L-buthionine (SR)-sulfoximine, which inhibits GSH synthesis. Downregulatio…
Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis.
2005
Objective— Sedentary lifestyle is associated with increased cardiovascular events. The underlying molecular mechanisms are incompletely understood. Reactive oxygen species (ROS) contribute to endothelial dysfunction and atherosclerosis. An important source of vascular ROS is the NADPH oxidase. Methods and Results— C57BL6 mice were subjected to regular housing (physical inactivity) or voluntary training on running wheels (6 weeks). Inactivity increased vascular lipid peroxidation to 148±9% and upregulated superoxide release to 176±17% (L-012 chemiluminescence) and 188±29% (cytochrome C reduction assay), respectively. ROS production was predominantly increased in the endothelium and the medi…
Radiographic Assessment of Tibiofibular Syndesmosis Injury with Different Durations and Types of Fixation
2022
Introduction: There is no consensus among orthopedic surgeons on the number of cortical layers (tricortical or quadricortical fixation) involved or the duration of syndesmotic fixation after a tibiofibular syndesmosis (TFSD)-injury treatment. The purpose of this study was to assess radiographic parameters following the treatment of TFSD injuries, with various time-windows of syndesmotic screw removal and numbers of cortical layers involved. Materials and Methods: Fifty-five patients, aged from 25 to 75 years, were included in the study. The follow-up period ranged from 2 years to 4 years and 2 months. The patients were subdivided into groups based on the duration of the syndesmotic fixation…
OSTEORADIONECROSIS OF THE JAW AFTER HEAD/NECK RADIOTHERAPY: CAUSES AND MANAGEMENT
2019
Radiation therapy in combination with surgery and chemotherapy is the most common oncologic treatment for head and neck tumors. This combination of different therapies rappresents a successful treatment, however there are adverse side effects, the most severe and serious is the osteroradionecrosis (ORN). The primary treatment for ORN is to prevent its occurrence thus the best preventive procedure is to insert all patients in to a pre-cancer treatment dental protocol.
Efectos del ibandronato sobre el metabolismo óseo y el perfil de riesgo cardiovascular en mujeres con osteoporosis postmenopáusica tratadas previamen…
2015
“Efectos del ibandronato sobre el metabolismo óseo y el perfil de riesgo cardiovascular en mujeres con osteoporosis postmenopáusica tratadas previamente con raloxifeno” La osteoporosis postmenopáusica es un problema sanitario mundial, dado que las fracturas por fragilidad suponen un aumento importante de morbimortalidad así como del coste económico. En los últimos años se han desarrollado nuevas terapias para el tratamiento de la osteoporosis, siendo por el momento los SERMs y los bisfosfonatos los fármacos más empleados. El Raloxifeno está aprobado como tratamiento de la osteoporosis postmenopáusica con el objetivo de prevenir las fracturas osteoporóticas. Ha demostrado un aumento progresi…
Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice.
2018
Accumulating evidence indicates that gut microbiota plays a significant role in obesity, insulin resistance and associated liver disorders. Family Enterobacteriaceae and especially Enterobacter cloacae strain B29 have been previously linked to obesity and hepatic damage. The underlying mechanisms, however, remain unclear. Therefore, we comprehensively examined the effects of E. cloacae subsp. cloacae (ATCC® 13047™) administration on host metabolism of mice fed with high-fat diet (HFD). C57BL/6N mice were randomly divided into HFD control, chow control, and E. cloacae treatment groups. The E. cloacae treatment group received live bacterial cells in PBS intragastrically twice a week, every ot…
Lack of reactivation of tuberculosis in patients with psoriasis treated with secukinumab in a real-world setting of latent tuberculosis infection
2022
Background Some biologics for psoriasis, especially anti-tumor necrosis factor (TNF)-alpha therapies, may re-activate latent tuberculosis (TBC) infection with consequent morbidity and mortality. However, there is a low reported incidence of conversion to positive TBC status among patients with psoriasis treated with second-generation biologic therapies, particularly anti-interleukin (IL)-17 therapies such as secukinumab. Objectives To evaluate the safety profile of secukinumab in psoriasis patients with latent TBC infection. Methods Real-life data were collected by retrospective chart review on patients with moderate-to-severe psoriasis who showed positivity for TBC screening at baseline an…