Search results for "OTHER"
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Tolerogenic Dendritic Cells for Regulatory T Cell Induction in Man.
2015
Dendritic cells are (DC) highly specialized professional antigen-presenting cells (APC) that regulate immune responses, maintaining the balance between tolerance and immunity. Mechanisms via which they can promote central and peripheral tolerance include clonal deletion, inhibition of memory T cell responses, T cell anergy and induction of regulatory T cells. These properties have led to the analysis of human tolerogenic DC as a therapeutic strategy for induction or re-establishment of tolerance. In the recent years, numerous protocols for the generation of human tolerogenic DC have been developed and their tolerogenic mechanisms, including induction of regulatory T cells, are relatively we…
Blockade of MIF–CD74 Signalling on Macrophages and Dendritic Cells Restores the Antitumour Immune Response Against Metastatic Melanoma
2018
Mounting an effective immune response against cancer requires the activation of innate and adaptive immune cells. Metastatic melanoma is the most aggressive form of skin cancer. While immunotherapies have shown a remarkable success in melanoma treatment, patients develop resistance by mechanisms that include the establishment of an immune suppressive tumor microenvironment. Thus, understanding how metastatic melanoma cells suppress the immune system is vital to develop effective immunotherapies against this disease. In this study, we find that macrophages (MOs) and dendritic cells (DCs) are suppressed in metastatic melanoma and that the Ig-CDR-based peptide C36L1 is able to restore MOs and …
Evaluating Safety Systems for Machine Tools with Computer Numerical Control using Analytic Hierarchy Process
2019
Computer numerical control (CNC) machine tools are complex production systems with fully automatic machine parts. Nowadays, high feed rates and machining speeds are used during the machining process. Human operators are still needed to set-up the machine, load/unload workpieces and parts, load the machining code, and supervise the machining process. The operators work in an environment where automated high-speed motions occur, and consequently, CNC machine tools have to be equipped with safety systems. The approach presented in this paper was to evaluate the main safety systems of CNC machine tools based upon the analytic hierarchy process (AHP). The analyzed systems were divided into six m…
Vγ9Vδ2 T cells as a promising innovative tool for immunotherapy of hematologic malignancies
2011
The potent anti-tumor activities of γδ T cells, their ability to produce pro-inflammatory cytokines, and their strong cytolytic activity have prompted the development of protocols in which γδ agonists or ex vivo-expanded γδ cells are administered to tumor patients. γδ T cells can be selectively activated by either synthetic phosphoantigens or by drugs that enhance their accumulation into stressed cells as aminobisphosphonates, thus offering new avenues for the development of γδ T cell-based immunotherapies. The recent development of small drugs selectively activating Vγ9Vδ2 T lymphocytes, which upregulate the endogenous phosphoantigens, has enabled the investigators to design the experiment…
Low molecular weight heparins in cancer patients: to treat thromboembolic events, the tumor, or both?
2011
The interrelationship between cancer and thrombosis is well known. Recent data help physicians to optimize the management of thrombotic complications occurring in cancer patients. However, many issues are still uncertain. First, although the development of venous thromboembolism (VTE) in a patient with known cancer is the most common presentation, concerns remain about the optimal duration and dosages of anticoagulants. Questions also arise concerning the need to implement heparin prophylaxis in the course of chemotherapy. Secondly, in some patients, thrombosis precedes the diagnosis of malignancy. In this case, the question is whether or not to screen patients for an occult cancer. Thirdly…
Bibliometric Research in Technology-Mediated Learning with High Capacity Students
2020
RESUMEN: Este trabajo implica una revisión del trabajo de investigación sobre el aprendizaje mediado por tecnología en estudiantes de alta capacidad. El estudio fue realizado por medio de un análisis bibliométrico de la producción científica en la renombrada base de datos Scopus. Fueron evaluados, sin filtro temporal, 35 artículos publicados entre 1993 y 2018, de los cuales se analizó una selección de indicadores de productividad científica, colaboración, consumo e impacto, así como variables estructurales y de contenido. Aunque el número de artículos no sea muy alto, los resultados mostraron un aumento en las publicaciones científicas recientes centradas en procesos de aprendizaje mediados…
A Educação para a Cidadania Mundial como aposta de construção de um novo paradigma educativo
2018
Resumo : O objetivo com este estudo e refletir sobre a Cidadania Mundial, por meio de uma investigacao sobre o tema, considerando a evidencia da sua permanencia como prioridade na agenda educativa mundial, tanto para os paises desenvolvidos, quanto para os em desenvolvimento. A Educacao para a Cidadania Mundial tem cobrado ao longo dos ultimos anos um claro protagonismo na reflexao e nas praticas educativas, tanto das organizacoes nao governamentais quanto dos docentes mais comprometidos com um pensar e uma pratica pedagogica alternativa nas suas aulas. Sua inclusao preeminente na agenda global como raiz de sua definicao prioritaria para o marco da Global Education First Initiative (GEFI), …
'Different' and 'distinct' as markers of otherness: A corpus-driven study of the (re)creation of privilege in high standard hotels.
2020
The present study seeks to offer an understanding of how high-end hotel websites produce privilege, creating a sense of belonging and entitlement for their 4/5-star guests. The experience of tourism is intrinsically linked to embracing otherness, and as a reflection of this, hotel websites offer a characterization of cultural otherness in an attempt to make it resonate with the potential expectations of a socioeconomically privileged client. The study considers the question of what elements of experience of otherness the website will address, relying on a Critical Discourse Analysis perspective and drawing on Bourdieu's notion of habitus as related to lifestyle, difference and distinction. …
Transgenic Killer Commensal Bacteria as Mucosal Protectants
2001
As first line of defense against the majority of infections and primary site for their transmission, mucosal surfaces of the oral cavity and genitourinary, gastrointestinal, and respiratory tracts represent the most suitable sites to deliver protective agents for the prevention of infectious diseases. Mucosal protection is important not only for life threatening diseases but also for opportunistic infections which currently represent a serious burden in terms of morbidity, mortality, and cost of cures. Candida albicans is among the most prevalent causes of mucosal infections not only in immuno- compromised patients, such as HIV-infected subjects who are frequently affected by oral and esoph…
Mafia, psicopatologia e psicoterapia: spunti di riflessione a partire da un percorso di ricerca
2013
L‟articolo affronta i temi legati al lavoro psicoterapeutico con soggetti appartenenti a famiglie mafiose a partire da una ricerca condotta su un campione di psicoterapeuti delle tre regioni in cui l‟organizzazione criminale è storicamente più forte e radicata (Sicilia, Campania, Calabria). Dopo le stragi del ‟92, infatti, l‟intera organizzazione Cosa Nostra entra in crisi e con essa i suoi membri. A partire da quegli anni la sofferenza psichica di questi soggetti comincia a trapelare al di fuori di queste realtà attraverso un‟esplicita domanda d‟aiuto agli psicoterapeuti operanti nei servizi di salute mentale o nel privato. Che cosa significa per un terapeuta aiutare un paziente a svelare …