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Extracellular Vesicles: The New Frontier of Stem Cell Regenerative Medicine?

2020

Regenerative medicine aims to repair damaged or missing cells, tissues or organs for the treatment of various diseases, poorly managed with conventional drugs and medical procedures. To date there are different approaches to obtain these results. Multimodal regenerative methods include transplant of healthy organs, tissues, or cells, body stimulation to activate a self healing response in damaged tissues, as well as the combined use of cells and bio-degradable scaffold to obtain functional tissues. Certainly, stem cells and derived products are promising tools in regenerative medicine due to their ability to induce de novo tissue formation and/or promote tissue and organ repair and regenera…

Tracking Healing Process of Experimental Liver Injuries Treated with Different Sealants and Adhesives Biomaterials. Matrix Metalloproteinase Evaluati…

2018

Sealants and adhesives are used in the repair and preservation of damaged solid organs. This study examines the matrix metalloproteinases (MMP) activity in the healing of liver injuries treated with two biological adhesives (Tachosil® and GelitaSpon®) as well as that of a new elastic cyanoacrylate (Adhflex®). Methods. We induced in 90 male rats hepatic lesions using a Stiefel biopsy punch in the liver. Wound healing was assessed 2, 6, and 18 days after injury by quantifying MMP1, 2, 8, 9, and 13 tissue levels. The histopathological repair was evaluated by hematoxylin-eosin, Masson’s trichrome, and Periodic Acid Schiff (PAS) staining and CD31, CD68 immunohis…

Purcell Enhancement and Wavelength Shift of Emitted Light by CsPbI3 Perovskite Nanocrystals Coupled to Hyperbolic Metamaterials

2020

Manipulation of the exciton emission rate in nanocrystals of lead halide perovskites (LHPs) was demonstrated by means of coupling of excitons with a hyperbolic metamaterial (HMM) consisting of alternating thin metal (Ag) and dielectric (LiF) layers. Such a coupling is found to induce an increase of the exciton radiative recombination rate by more than a factor of three due to the Purcell effect when the distance between the quantum emitter and HMM is nominally as small as 10 nm, which coincides well with the results of our theoretical analysis. Besides, an effect of the coupling-induced long wavelength shift of the exciton emission spectrum is detected and modeled. These results can be of i…

Utilization of limnocrenic karst springs in south-western Poland in balneotherapy and spa healthcare

2015

Polska należy do krajów bogatych w wodę i ten zasób może być z powodzeniem stosowany w celach leczniczych, jak również w przemyśle spożywczym, chemicznym i grzewczym. Do obszarów o dużym znaczeniu perspektywicznym posiada, m.in. Śląsk Opolski w południowo-zachodniej Polsce, należący częściowo do prowincji Sudetów, która biegnie wzdłuż południowych granic Polski, Czech i Niemiec. Do tej pory obszar ten był znany z wysoko zmineralizowanych kwaśnych wód termalnych z Grabina koło Grodkowa, które są planowane do wykorzystania dla celów leczniczych w lecznictwie uzdrowiskowym. Podczas badań hydrologicznych prowadzonych na Śląsku Opolskim w latach 2010–2015, stwierdzono obecność nieznanych, średni…

From arsenic to DDT: Pesticides, Fascism and the invisibility of toxic risks in the early years of Francoist Spain (1939-1953)

2021

This paper reviews the way in which Spanish agriculture climbed onto the pesticide treadmill. We claim that Fascist policies and expert advice assembled in the early 1940s accelerated the introduction of pesticides into Spanish agriculture and promoted the emergence of the Spanish pesticide industry in the times of autarky. Agricultural engineers were the key protagonists in this process, but other human and non-human actors also played a pivotal role: a new pest (the Colorado beetle), Francoist politicians, farmers, landowners and industry managers. Our focus is on the use of pesticides against the Colorado beetle (the main threat to the potato crop), and the transition from arsenical pest…

Mastering the Tools: Natural versus Artificial Vesicles in Nanomedicine

2020

Naturally occurring extracellular vesicles and artificially made vesicles represent important tools in nanomedicine for the efficient delivery of biomolecules and drugs. Since its first appearance in the literature 50 years ago, the research on vesicles is progressing at a fast pace, with the main goal of developing carriers able to protect cargoes from degradation, as well as to deliver them in a time- and space-controlled fashion. While natural occurring vesicles have the advantage of being fully compatible with their host, artificial vesicles can be easily synthetized and functionalized according to the target to reach. Research is striving to merge the advantages of natural and artifici…

Immune-Biomarkers in Advanced Non-Small Cell Lung Cancer

2021

N.A Background: Developing personalized immunotherapy-based approaches, through the identification of predictive immune-related biomarkers, is still a main topic for translational lung cancer research. In the present study we investigated whether baseline tissue “immune-related gene signatures”, as well as plasma chemo-cytokines profiles, could predict sensitivity/resistance to immune-checkpoint inhibitors in pre-treated patients with advanced non-small cell lung cancer (NSCLC). Methods: From September 2015 to September 2018, 150 patients with previously treated advanced NSCLC who received either anti-PD1 or anti-PD-L1 inhibitors in the second-third line setting were included within this tr…

Climate change influences on aviation: A literature review

2020

While the aviation sector has long been referenced as contributing to the causes of climate change, the need for aviation to adapt to the consequences of climate change has not been as well researched or considered. The paper is a systematic quantitative literature review on climate change and aviation, which aims to explicate significant issues affecting aviation in a changing climate and to identify the aviation industry responses on climate change and adaptation. There are 46 references involved in the detailed assessment, selected according to variables such as methodology, paper outcomes and industry stakeholder. This emergent aviation and climate change adaptation literature could be …

Катя в моих воспоминаниях : [памяти Екатерины Юрьевны Гениевой (1946-2015), бывшего генерального директора Всероссийской государственной библиотеки и…

2016

Aménités urbaines et périurbaines dans une aire métropolitaine de forme fractale

2002

In the THÜNEN tradition, Urban Economy is a striking abstraction, giving models that keep the main features of the wide diversity of real word cities. Nevertheless, this paradigm less suits the modern urban spatial structures (polycentrism, weak centripetal forces, etc.), particularly the peri-urban form of metropolitan areas, which are an urban/rural integrated space. In this paper, we propose a classical micro-economic urban model combined with a " SIERPINSKI's carpet " geometry, a fractal form which suits for fit together urban and rural areas in a hierarchical structure. Subject to a budget constraint, a household maximises a Cobb-Douglas/CES function, where household's taste for divers…