Search results for "OTHER"

L'implantation des gares TGV en France: tensions interscalaires, jeux d'acteurs et recompositions spatiales

2010

L’extension du réseau de lignes à grande vitesse renouvelle le problème du positionnement des gares, notamment en France qui privilégie une logique d’efficacité fondée sur des dessertes rapides et cadencées entre grandes métropoles au détriment des espaces intermédiaires. Cette option se traduit par deux types de localisation : gare principale centrale pour les plus grandes villes et gare périphérique pour les villes petites et moyennes. Ces choix d’implantation résultent de processus interactifs qui concernent tous les niveaux de l’organisation spatiale. Ainsi, si on examine les processus de décision ayant conduit à l’implantation des gares TGV en France, ces choix et les stratégies de val…

Outlying location of logistics activities : the example of the Burgundy in France

2015

International audience; This paper contributes to the understanding of spatial location of logistics activities in an outlying region. A quantitative analysis in Burgundy (French region) underlines the important polarization of warehousing developed in a limited area during 1980–1990s intensified during 2000s. The companies that locate their warehouses in Burgundy have different strategies that could explain this outlying location. For example, the low cost of land, favorable terms of tax system and the presence of a labour pool with an important unemployed rate incentive could incentive some companies to locate their warehouses in an outlying region like the Burgundy.

Filozofia jako ćwiczenie duchowe. Coachingowy model uprawiania filozofii

2018

Główną tezą tekstu jest uznanie tzw. modelu coachingowego za pierwotny i wciąż żywy sposób uprawiania filozofii. Twierdzę, że filozofia akademicka, która od kilku stuleci tkwi w tradycji scholastycznej, może być uprawiana w modelu coachingowym. W drugim paragrafie przedstawiam odróżnienie dwóch rodzajów filozofowania: Sokratejskiego – określonego w tekście mianem „coachingowego” – oraz Arystotelesowskiego, nazywanego tutaj „scholastycznym”. W trzecim paragrafie pokazuję, w jaki sposób Wiktor Frankl nawiązuje do coachingowej tradycji uprawiania filozofii w swojej praktyce terapeutycznej. W czwartym przedstawiam przykłady zastosowania modelu coachingowego w dydaktyce filozofii.

Biology of the sauropod dinosaurs: the evolution of gigantism

2010

The herbivorous sauropod dinosaurs of the Jurassic and Cretaceous periods were the largest terrestrial animals ever, surpassing the largest herbivorous mammals by an order of magnitude in body mass. Several evolutionary lineages among Sauropoda produced giants with body masses in excess of 50 metric tonnes by conservative estimates. With body mass increase driven by the selective advantages of large body size, animal lineages will increase in body size until they reach the limit determined by the interplay of bauplan, biology, and resource availability. There is no evidence, however, that resource availability and global physicochemical parameters were different enough in the Mesozoic to ha…

Combining Sequence Analysis and Hidden Markov Models in the Analysis of Complex Life Sequence Data

2018

Life course data often consists of multiple parallel sequences, one for each life domain of interest. Multichannel sequence analysis has been used for computing pairwise dissimilarities and finding clusters in this type of multichannel (or multidimensional) sequence data. Describing and visualizing such data is, however, often challenging. We propose an approach for compressing, interpreting, and visualizing the information within multichannel sequences by finding (1) groups of similar trajectories and (2) similar phases within trajectories belonging to the same group. For these tasks we combine multichannel sequence analysis and hidden Markov modelling. We illustrate this approach with an …

Механика композитных материалов, 2022, Т. 58, No 1, Январь-февраль

2022

Early palliative care of non‑small cell lung cancer in the context of immunotherapy (Review)

2020

Abstract. The most common cause of mortality due to malig‑ nant neoplasms in the general population around the world is lung cancer. In the last 10 years, there has been an enormous improvement in the treatment of this disease, mainly due to the immunotherapy that activates the immune system to fight cancer. Patients with metastatic non‑small cell lung cancer are a special group of patients requiring not only cancer treatment but also considerable support in the treatment of cancer‑related problems, as well as comorbidities. Early palliative care is important in this area. In addition, there is certain evidence that medicines most commonly administered in palliative care may lower the effic…

Differential influence of vemurafenib and dabrafenib on patient lymphocytes despite similar clinical efficacy in melanoma

2014

Background: Since the majority of melanomas eventually become resistant and progress, combining selective BRAF inhibitors (BRAFi) with immunotherapies has been proposed to achieve more durable treatment responses. Here, we explored the impact of selective BRAFi on the hosts’ immune system. Patients and methods: Clinical data, whole blood counts (WBC) and serum lactate dehydrogenase (LDH) of 277 vemurafenib- and 65 dabrafenib-treated melanoma patients were evaluated. The frequency and phenotype of lymphocyte subpopulations were determined by flow cytometry while T cell cytokine secretion was measured by multiplex assays. Results: Progression-free survival (PFS) as well as overall survival (O…

Closed due to COVID-19: effects of indoor sports restrictions on suburban adults’ physical activity behaviours

2023

During the COVID-19 pandemic, people have been required adaptations in leisure-time physical activity (PA) especially due to restrictive policies concerning indoor sport facilities (ISF). This study investigated the effects of the constraints on ISF among residents of two low socioeconomic status suburbs in Finland. Research questions were: (1) Are sociodemographic characteristics associated with a reduced use of ISF during the pandemic? (2) Are sociodemographic characteristics associated with changes in the overall PA amount among those respondents with a reduced use of ISF? (3) Is the reduced use of ISF associated with an increased use of other PA environments (home environment, built out…

El análisis marxista de las necesidades sociales

2018

The disappearance of the so-called «real socialism» has concealed the validity of the Marxist analysis of social reality. One of the sets of hypotheses that has best maintained its heuristic capacity is the Marxist theory of needs. The Marxist hypotheses have been developed in debate with other conventional conceptions. Currently, feminism and the ecological analysis of needs are renewing the views of Heller and Habermas.