Search results for "OXY"

Apoptotic-like Leishmania exploit the host´s autophagy machinery to reduce T-cell-mediated parasite elimination

2015

Apoptosis is a well-defined cellular process in which a cell dies, characterized by cell shrinkage and DNA fragmentation. In parasites like Leishmania, the process of apoptosis-like cell death has been described. Moreover upon infection, the apoptotic-like population is essential for disease development, in part by silencing host phagocytes. Nevertheless, the exact mechanism of how apoptosis in unicellular organisms may support infectivity remains unclear. Therefore we investigated the fate of apoptotic-like Leishmania parasites in human host macrophages. Our data showed--in contrast to viable parasites--that apoptotic-like parasites enter an LC3(+), autophagy-like compartment. The compartm…

Evaluation of the efficacy of a new insecticide paint against malaria vectors

2015

La malaria continúa siendo un problema de salud pública global. Se calcula que en el mundo hay 3.300 millones de personas en 97 países y territorios que corren el riesgo de padecer el paludismo, y que para 1.200 millones ese riesgo es elevado (WHO, 2014). El control de la malaria a gran escala está altamente basado en al control del vector, principalmente mediante el uso de mosquiteras tratadas con insecticidas de larga duración (LLINs), y en menor medida, el Rociamiento Residual Intradomiciliario. Todos los tratamientos recomendados de LLINs y la mayoría del Rociamiento Residual Intradomiciliario se basan en el uso de piretroides. La creciente resistencia de los vectores de malaria a los p…

A minireview on NHE1 inhibitors. A rediscovered hope in oncohematology.

2015

Background: Na+/H+ exchanger-1 (NHE-1) is involved in pH regulation and is up-regulated in different malignancies. Activation of NHE-1 is one way for allowing cells to avoid intracellular acidification and protect them against apoptosis. Inhibitors of NHE-1 are able to decrease intracellular pH and induce apoptosis. Some statins can also act by partial inhibition of NHE-1. This review presents progress in understanding the mechanisms of action of these inhibitors, connections with certain genetic mutations and acquired treatment resistance, as well as new patents on them. Methods: A MEDLINE search for original and review articles using key terms, Na+/H+ exchanger, leukemia, cariporide, and …

Low-weight carboxylic acids as potential risk factor of compost phytotoxicity

2009

Being intermediates of organic matter degradation, low-weight carboxylic acids (LWCA) can occur at phytotoxic concentrations on bioactive soils or in the processed organic material applied to soil. While toxicity potentials and mixture effects of LWCA are still poorly known, the potential phytotoxicity of the biomaterials is difficult to assess. In the study effective concentrations (EC) of formic, acetic and propionic acids at non adjusted pH were obtained in short-term germination assays (48 h for cress, Lepidium sativum, and 120 h for ryegrass Lolium multiflorum) and subchronic growth assays (21d). Based on the EC values, LWCA inhibited more strongly plant growth than seed germination. I…

Intraforaminal lumbosacral discal herniation. Treatment of symptomatic patients with intradiscal injection oxygen-ozone (O2-O3) mixture

2007

Role of low-weight carboxylic acids in phytotoxicity of composts

2013

Machine Learning for Predicting Chemical Potentials of Multifunctional Organic Compounds in Atmospherically Relevant Solutions

2022

We have trained the Extreme Minimum Learning Machine (EMLM) machine learning model to predict chemical potentials of individual conformers of multifunctional organic compounds containing carbon, hydrogen, and oxygen. The model is able to predict chemical potentials of molecules that are in the size range of the training data with a root-mean-square error (RMSE) of 0.5 kcal/mol. There is also a linear correlation between calculated and predicted chemical potentials of molecules that are larger than those included in the training set. Finding the lowest chemical potential conformers is useful in condensed phase thermodynamic property calculations, in order to reduce the number of computationa…

Effects of forest-fuel harvesting on the diversity of dead wood and epixylic macrolichens in clear-cuts

2016

Energiapuuta käytetään yhä enemmän uusiutuvan energian lähteenä. Energiapuun korjuussa hakkuutähteitä eli kantoja, oksia ja latvuksia kerätään päätehakkuun ja harvennuksen yhteydessä hakkuualoilta. Tämä vähentää erityisesti pienikokoisen lahopuun ja kantojen määrää. Lahopuu on tärkeä resurssi boreaalisissa metsissä, mutta sen määrä talousmetsissä on alhainen luonnonmetsiin verrattuna. Määrän väheneminen edelleen energiapuun korjuun seurauksena voi johtaa lahopuusta riippuvaisen monimuotoisuuden vähenemiseen, minkä vuoksi on tärkeää tutkia energiapuun korjuun monimuotoisuusvaikutuksia. Teoriat pinta-alan ja habitaatin heterogeenisyyden vaikutuksesta lajimäärään ovat yksiä tärkeimmistä lajimä…

Controlling the atmosphere in the malaxation machine headspace in order to improve the quality of Sicilian extra virgin olive oils

2012

During the mechanical extraction process of Virgin Olive Oil (VOO) some important physical phenomena and enzymatic transformations occur influencing the final product quality. The control of process parameters is crucial to ensure the quality of VOO, therefore process monitoring and control is a fundamental requirement in the modern VOO processing industry. The present work proposes a research performed in order to develop a system for the oxygen continuous monitoring inside the malaxation machine to enhance the Sicilian extra virgin olive oil typicality and to establish a correlation with the quality of the final product. The results showed that the use of oxygen during malaxation, allowed…

Review of George W. Houston, Inside Roman Libraries: Book Collections and Their Management in Antiquity

2017

By examining in detail the results of George W. Houston's recent research on Roman libraries, the present contribution discusses the structure, content, and socio-cultural function of book collections in the Roman world. Special attention is devoted to the (often overlooked) relationship between intellectual trends and material culture as well as to the highly representative sites of Herculaneum and Oxyrhynchus.