Search results for "Observational study"

showing 10 items of 776 documents

Digoxin and prognosis of heart failure in older patients with preserved ejection fraction: Importance of heart rate. Results from an observational an…

2018

Abstract Background The value of digoxin in heart failure (HF) remains controversial, particularly in patients with preserved ejection fraction (HFpEF). This study evaluated the 1-year risk of events after digoxin treatment for acute heart failure (AHF) in patients >70 years old with HFpEF. Methods 1833 patients were included in this analysis (mean age, 82 years). The main endpoints were all-cause death and the composite of death and/or HF re-admission within 1 year. Cox regression analysis was used to evaluate the association between digoxin treatment and prognosis. Results 401 patients received digoxin treatment; of these, 86% had atrial fibrillation. The mean baseline heart rate was 86 ±…

MaleDigoxinmedicine.medical_specialtyCardiotonic AgentsDigoxin030204 cardiovascular system & hematologyPatient Readmission03 medical and health sciences0302 clinical medicineOlder patientsHeart RateRisk FactorsCause of DeathInternal medicineAtrial FibrillationHeart rateInternal MedicinemedicineHumansProspective StudiesRegistries030212 general & internal medicineAgedProportional Hazards ModelsAged 80 and overHeart FailureEjection fractionProportional hazards modelbusiness.industryStroke VolumeAtrial fibrillationPrognosismedicine.diseasePatient DischargeSpainHeart failureMultivariate AnalysisCardiologyFemaleObservational studybusinessmedicine.drugEuropean Journal of Internal Medicine
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Gross motor proficiency and intellectual functioning

2018

Abstract This cross-sectional study examines differences in gross motor proficiency as a function of different intellectual functioning profiles. Two motor areas have been investigated as being equally essential to gross motor functions in every-day life: locomotion and object control. It aims to compare gross motor skills endorsed by children with Down syndrome (DS), children with borderline intellectual functioning (BIF), and typically developing children (TDC). Group 1 was composed of 18 children with DS (chronological age = 8.22), group 2 was composed of 18 children with BIF (chronological age = 9.32), and group 3 was composed of 18 children with typical development (TD) (chronological …

MaleDown syndromeObservational Studygross motor development7000sport rehabilitationlocomotionMotor Skills Disordersobject controlChild DevelopmentCross-Sectional StudiesIntellectual Disabilityborderline intellectual functioningHumansFemaleChildResearch ArticleMedicine
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Effectiveness of anti-vascular endothelial growth factors in neovascular age-related macular degeneration and variables associated with visual acuity…

2021

Objective To assess the overall effectiveness of anti-vascular endothelial growth factor (VEGF) therapy in treatment-naïve patients with neovascular age-related macular degeneration (nAMD) in a clinical practice setting. Study design EAGLE was a retrospective, 2-year, cohort observational, multicenter study conducted in Italy that analyzed secondary data of treatment-naïve patients with nAMD. The primary endpoint evaluated the mean annualized number of anti-VEGF injections at Years 1 and 2. The main secondary endpoints analyzed the mean change in visual acuity (VA) from baseline and variables associated with visual outcomes at Years 1 and 2. Results Of the 752 patients enrolled, 745 (99.07…

MaleEaglesAntiVEGF Drugs nAMD clinical practiceVisual AcuitySocial SciencesRetinal NeovascularizationInfographicsGeographical locationsMacular DegenerationMedical ConditionsEndocrinologyRetrospective StudieClinical endpoint80 and overPsychologyAged 80 and overEukaryotaItalyCohortMedicineHumanmedicine.medical_specialtyScienceDrug Administration ScheduleFollow-Up StudieSigns and Symptomsbiology.animalLinear regressionHumansAgedRetrospective StudiesSettore MED/30 - Malattie Apparato VisivoData VisualizationOrganismsBiology and Life Sciencesmedicine.diseaseOphthalmologyMacular DisordersLesionsEyesObservational studyClinical MedicinePeople and placesNeuroscienceVascular Endothelial Growth Factor AVisual acuityTime FactorsEye DiseasesVisionPhysiologyAngiogenesis InhibitorsMedicine and Health SciencesGeriatric OphthalmologyData ManagementMultidisciplinarybiologyQRetinal DegenerationRChartsEuropeAged; Aged 80 and over; Angiogenesis Inhibitors; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Intravitreal Injections; Italy; Macular Degeneration; Male; Retinal Neovascularization; Retrospective Studies; Time Factors; Treatment Outcome; Vascular Endothelial Growth Factor A; Visual AcuityTreatment OutcomeVertebratesIntravitreal InjectionsRetinal DisordersSensory PerceptionFemalemedicine.symptomAnatomyAngiogenesis InhibitorResearch ArticleEagleComputer and Information SciencesTime FactorBirdsOcular SystemInternal medicineSettore MED/30Growth FactorsmedicineAnimalsEuropean UnionRaptorsEndocrine Physiologybusiness.industryIntravitreal InjectionCognitive PsychologyRetrospective cohort studyMacular degenerationGeriatricsAmniotesCognitive SciencePerceptionbusinessZoologyHeadFollow-Up Studies
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Epidemiology and diagnostic and therapeutic management of febrile seizures in the Italian pediatric emergency departments: A prospective observationa…

2015

AIM: Febrile seizures (FS) involve 2-5% of the paediatric population, among which Complex FS (CFS) account for one third of accesses for FS in Emergency Departments (EDs). The aim of our study was to define the epidemiology, the clinical, diagnostic and therapeutic approach to FS and CFSs in the Italian EDs. METHODS: A multicenter prospective observational study was performed between April 2014 and March 2015. Patients between 1 and 60 months of age, randomly accessing to ED for ongoing FS or reported FS at home were included. Demographic features and diagnostic-therapeutic follow-up were recorded. FS were categorized in simple (<10min), prolonged (10-30min) and status epilepticus (>3…

MaleEmergency Medical ServicesPediatricsNeurologyFebrileEpilepsyStatus Epilepticus0302 clinical medicineBolus (medicine)EpidemiologyPrevalenceItalian populationEpidemiologic studyProspective StudiesChildPediatricEmergency ServiceAge FactorsSettore MED/38Emergency department; Epidemiologic study; Italian population; Pediatrics; Simple and complex febrile seizures;ItalyNeurologyChild PreschoolPopulation studyAnticonvulsantsFemaleEmergency Service HospitalEmergency department; Epidemiologic study; Italian population; Pediatrics; Simple and complex febrile seizures; Age Factors; Anticonvulsants; Child Preschool; Emergency Medical Services; Emergency Service Hospital; Female; Follow-Up Studies; Humans; Infant; Italy; Male; Prevalence; Prospective Studies; Seizures Febrile; Status Epilepticusmedicine.drugmedicine.medical_specialtypediatricsSeizures FebrileNOHospital03 medical and health sciencesSeizures030225 pediatricsmedicineHumansPreschoolEmergency departmentbusiness.industrySimple and complex febrile seizuresInfantEmergency departmentmedicine.diseaseemergency department; epidemiologic study; italian population; pediatrics; simple and complex febrile seizures; neurology; neurology (clinical)MidazolamObservational studyNeurology (clinical)business030217 neurology & neurosurgeryFollow-Up StudiesEpilepsy Research
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Pasireotide treatment reduces cardiometabolic risk in Cushing’s disease patients: an Italian, multicenter study

2018

Purpose: Patients with Cushing’s disease (CD) experience metabolic alterations leading to increased cardiovascular mortality. Recently, the visceral adiposity index (VAI) has been proposed as a marker of visceral adipose tissue dysfunction (ATD) and of the related cardiometabolic risk. We aimed to evaluate the impact of 12-month pasireotide treatment on cardiometabolic risk in CD patients. Methods: This is a multicentre, prospective, and observational study. Sixteen CD patients, referred to the Endocrine Units of the University Hospitals of Messina, Napoli, Padova, and Palermo (Italy), successfully treated with pasireotide for 12 month have been enrolled. In all patients, we assessed anthro…

MaleEndocrinology Diabetes and MetabolismCardiometabolic risk Cushing’s disease hypercortisolism pasireotide visceral adiposity indexLongitudinal StudieDisease030204 cardiovascular system & hematologySettore MED/13 - Endocrinologiachemistry.chemical_compound0302 clinical medicineEndocrinologyRisk FactorsMedicineLongitudinal StudiesProspective StudiesAdiposityFramingham Risk ScoreCushing’s diseaseCushing’s diseaseMiddle AgedPasireotideDiabetes and MetabolismHeart DiseaseItalyAtherosclerosiObesity AbdominalFemaleSomatostatinHumanAdultmedicine.medical_specialtyWaistHeart DiseasesHypercortisolism030209 endocrinology & metabolismIntra-Abdominal Fat03 medical and health sciencesMetabolic DiseasesInternal medicineDiabetes mellitusCardiometabolic risk; Cushing’s disease; Hypercortisolism; Pasireotide; Visceral adiposity index; Endocrinology Diabetes and Metabolism; EndocrinologyHumansPituitary ACTH Hypersecretionbusiness.industryRisk FactorCushing's diseaseAnthropometryAtherosclerosismedicine.diseasePasireotideCardiometabolic riskMetabolic DiseaseVisceral adiposity indexProspective StudiechemistryObservational studybusiness
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The family-oriented Open Dialogue approach in the treatment of first-episode psychosis : nineteen–year outcomes

2018

Open Dialogue (OD) is a family-oriented early intervention approach which has demonstrated good outcomes in the treatment of first-episode psychosis (FEP). Nevertheless, more evidence is needed. In this register-based cohort study the long-term outcomes of OD were evaluated through a comparison with a control group over a period of approximately 19 years. We examined the mortality, the need for psychiatric treatment, and the granting of disability allowances. Data were obtained from Finnish national registers regarding all OD patients whose treatment for FEP commenced within the time of the original interventions (total N = 108). The control group consisted of all Finnish FEP patients who h…

MaleFamily therapyPsychological interventionlong-term follow-upwork capabilitylaw.inventionCohort Studies0302 clinical medicineRandomized controlled triallawOutcome Assessment Health CareMedicinetyökykyRegistriesFinlanddisability pensionperheterapiaMiddle AgedPsychiatry and Mental healthSchizophreniaFemalefamily therapyseurantatutkimusCohort studyAdultkuolleisuusmedicine.medical_specialtyAdolescentYoung Adult03 medical and health sciencesEarly Medical InterventionFirst episode psychosisHumansPsychiatryBiological PsychiatryAgedskitsofreniabusiness.industryDisability pensionmedicine.diseasemortalityta3124030227 psychiatryschizophreniaantipsychoticshospital admissionPsychotic DisorderstyökyvyttömyyseläkkeetObservational studybusiness030217 neurology & neurosurgeryPsychiatry Research
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Metformin and health outcomes:An umbrella review of systematic reviews with meta-analyses

2021

Background:\ud \ud The objective was to capture the breadth of outcomes that have been associated with metformin use and to systematically assess the quality, strength and credibility of these associations using the umbrella review methodology.\ud \ud Methods:\ud \ud Four major databases were searched until 31 May 2020. Meta‐analyses of observational studies and meta‐analyses of randomized controlled trials (RCTs) (including active and placebo control arms) were included.\ud \ud Results:\ud \ud From 175 eligible publications, we identified 427 different meta‐analyses, including 167 meta‐analyses of observational studies, 147 meta‐analyses of RCTs for metformin vs placebo/no treatment and 11…

MaleGRADE meta-analysis metformin umbrellamedicine.medical_specialtyPregnancy Rateendocrine system diseasesClinical Biochemistry030204 cardiovascular system & hematologyOverweightBiochemistryBody Mass Indexlaw.invention03 medical and health sciences0302 clinical medicineMeta-Analysis as TopicRandomized controlled trialPregnancylawNeoplasmsInternal medicinemedicineHumansHypoglycemic AgentsObesity030212 general & internal medicinePrediabetesbusiness.industryGeneral MedicineOverweightProtective Factorsmedicine.diseaseMetforminMetforminDiabetes Mellitus Type 1Systematic reviewDiabetes Mellitus Type 2Cardiovascular DiseasesMeta-analysisFemaleObservational studymedicine.symptombusinessInfertility FemaleBody mass indexPolycystic Ovary SyndromeSystematic Reviews as Topicmedicine.drug
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Can Clinical and Surgical Parameters Be Combined to Predict How Long It Will Take a Tibia Fracture to Heal? A Prospective Multicentre Observational S…

2018

Background. Healing of tibia fractures occurs over a wide time range of months, with a number of risk factors contributing to prolonged healing. In this prospective, multicentre, observational study, we investigated the capability of FRACTING (tibia FRACTure prediction healING days) score, calculated soon after tibia fracture treatment, to predict healing time.Methods. The study included 363 patients. Information on patient health, fracture morphology, and surgical treatment adopted were combined to calculate the FRACTING score. Fractures were considered healed when the patient was able to fully weight-bear without pain.Results. 319 fractures (88%) healed within 12 months from treatment. Fo…

MaleGenetics and Molecular Biology (all)Immunology and Microbiology (all)lcsh:MedicineTibia fracture multicentre observational studyTibia Fracturefracture; healing; tibiaBiochemistry0302 clinical medicineOsteogenesisMedicineAdolescent; Adult; Female; Fracture Healing; Humans; Male; Middle Aged; Osteogenesis; Prospective Studies; Reproducibility of Results; Tibia; Tibial Fractures; Treatment Outcome; Young AdultProspective Studies030212 general & internal medicineYoung adultProspective cohort studyFracture Healing030222 orthopedicsGeneral MedicineMiddle Agedtibia fractureTreatment OutcomeAdolescent; Adult; Female; Fracture Healing; Humans; Male; Middle Aged; Osteogenesis; Prospective Studies; Reproducibility of Results; Tibia; Tibial Fractures; Treatment Outcome; Young Adult; Biochemistry Genetics and Molecular Biology (all); Immunology and Microbiology (all)Femaletibia fracturetibia FRACTure prediction healINGResearch ArticleAdultmedicine.medical_specialtyArticle SubjectAdolescentBone healingGeneral Biochemistry Genetics and Molecular BiologyNOYoung Adult03 medical and health sciencesHumansIn patientTibiaTime rangetibia FRACTure prediction healINGTibiaGeneral Immunology and Microbiologybusiness.industrylcsh:RReproducibility of ResultsSurgeryTibial FracturesObservational studybusinessBiochemistry Genetics and Molecular Biology (all); Immunology and Microbiology (all)
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The "gender factor" in wearing-off among patients with parkinson's disease: A post hoc analysis of DEEP study

2014

Background. The early detection of wearing-off in Parkinson disease (DEEP) observational study demonstrated that women with Parkinson’s disease (PD) carry an increased risk (80.1%) for wearing-off (WO). This post hoc analysis of DEEP study evaluates gender differences on WO and associated phenomena.Methods. Patients on dopaminergic treatment for ≥1 year were included in this multicenter observational cross-sectional study. In a single visit, WO was diagnosed based on neurologist assessment as well as the use of the 19-item wearing-off questionnaire (WOQ-19); WO was defined for scores ≥2. Post hoc analyses were conducted to investigate gender difference for demographic and clinical features …

MaleGenetics and Molecular Biology (all)medicine.medical_specialtyLevodopaParkinson's diseaseArticle SubjectCross-sectional studylcsh:MedicineDiseaseAged; Akathisia Drug-Induced; Antiparkinson Agents; Cross-Sectional Studies; Female; Gait; Humans; Levodopa; Male; Parkinson Disease; Risk Factors; Severity of Illness Index; Sex Factors; Medicine (all); Biochemistry Genetics and Molecular Biology (all); 2300lcsh:TechnologySeverity of Illness IndexBiochemistryGeneral Biochemistry Genetics and Molecular BiologyAntiparkinson AgentsLevodopaSex FactorsRisk FactorsInternal medicinePost-hoc analysisSeverity of illnessBIO/14 FarmacologiamedicineHumansProspective cohort studylcsh:ScienceGaitGeneral Environmental ScienceAgedAged; Akathisia Drug-Induced; Antiparkinson Agents; Cross-Sectional Studies; Female; Gait; Humans; Levodopa; Male; Parkinson Disease; Risk Factors; Severity of Illness Index; Sex Factors; Biochemistry Genetics and Molecular Biology (all); 2300; Medicine (all)2300business.industrylcsh:TMedicine (all)lcsh:RParkinson DiseaseGeneral Medicinemedicine.diseaseAkathisiaCross-Sectional StudiesDrug-InducedPhysical therapyObservational studylcsh:QFemalebusinessAkathisia Drug-InducedResearch Articlemedicine.drug
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Anorexia and Eating Patterns in the Elderly

2013

Objectives To evaluate the change in eating habits occurring in community- dwelling and institutionalized elderly subjects with senile anorexia. Design Cross- sectional, observational. Setting Community, nursing homes and rehabilitation or acute care facilities in four Italian regions. Participants A random sample of 526 subjects, aged 65 years and older (217 free living individuals, 213 residents in nursing homes, and 93 patients in rehabilitation and acute wards). Measurements All subjects underwent a multidimensional geriatric evaluation of: nutritional status, anthropometric parameters, health and cognitive status, depression, taste, chewing and swallowing function, and some hormones re…

MaleGerontologyAgingAnatomy and PhysiologySettore MED/09 - Medicina InternaEpidemiologyCross-sectional studyEating Disorderslcsh:MedicineAnorexia nervosaFood groupAcute careMedicinelcsh:Sciencemedia_commonAged 80 and overPsychiatryGeriatricsMultidisciplinarydigestive oral and skin physiologyEpidemiology of AgingAnorexiaMental HealthMedicineFemalemedicine.symptomeating pattern; senile anorexia; elderly; malnutritionResearch Articlesenile anorexiamedicine.medical_specialtymedia_common.quotation_subjectmalnutritionAnorexiaelderlyAnorexia aging nutrition malnutritionHumanseating patternBiologyAgedNutritionPopulation Biologybusiness.industrylcsh:RAppetiteFeeding Behaviormedicine.diseaseCross-Sectional StudiesGeriatricslcsh:QObservational studyPhysiological Processesbusiness
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