Search results for "Obstruction"

Which factors affect the choice of the inhaler in chronic obstructive respiratory diseases?

2015

Inhalation is the preferred route of drug administration in chronic respiratory diseases because it optimises delivery of the active compounds to the targeted site and minimises side effects from systemic distribution. The choice of a device should be made after careful evaluation of the patient's clinical condition (degree of airway obstruction, comorbidities), as well as their ability to coordinate the inhalation manoeuvre and to generate sufficient inspiratory flow. These patient factors must be aligned with the specific advantages and limitations of each inhaler when making this important choice. Finally, adherence to treatment is not the responsibility of the patient alone, but should …

The use of bronchodilators in the treatment of airway obstruction in elderly patients

2006

Abstract Ageing is associated with important anatomical, physiological and psychosocial changes that may have an impact on the management of obstructive airway diseases (asthma and chronic obstructive pulmonary disease (COPD)) and on their optimal therapy. Ageing-related modifications might be responsible for a different effectiveness of bronchodilators in the elderly patients as compared to younger subjects. Furthermore, the physiological involution of organs and the frequent comorbidity, often interfere with pharmacokinetics of bronchodilator drugs used in asthma and COPD. This review will focus on the use of bronchodilators in the elderly, with particular attention to the achievable goal…

Persistence of both reversible airway obstruction and higher blood eosinophils may predict lung function decline in severe asthma.

2021

Objective: This study analysed whether the persistence of both reversible airway obstruction (RAO) and elevated BE counts was associated to reduced asthma control and accelerated lung function decline in treated severe asthmatics. Methods: About 202 severe asthmatics were studied after 12–120 months of step-5 treatment associated to anti-IgE therapy. Following treatments, reversibility tests, after inhaling 400 mcg of Salbutamol, were performed. FEV1 > 12% or ≤12% changes differentiated RAO+ from RAO− subjects. Blood eosinophil (BE) counts after treatment were considered. Results: Pre-/post-treatment bronchodilator FEV1% and ACT were lower (61% [50–71], 74.4% [62.5–83.7] and 20[18–22]), …

Fibred-categorical obstruction theory

2022

Abstract We set up a fibred categorical theory of obstruction and classification of morphisms that specialises to the one of monoidal functors between categorical groups and also to the Schreier-Mac Lane theory of group extensions. Further applications are provided to crossed extensions and crossed bimodule butterflies, with in particular a classification of non-abelian extensions of unital associative algebras in terms of Hochschild cohomology.

Meta-analysis of the objective and subjective evaluation of nasal surgery

2021

Priekšvēsture: Nav vienota viedokļa par objektīvu un subjektīvu novērtēšanas metožu lietderību deguna elpceļu obstrukcijas novērtēšanā un ārstēšanas ietekmi uz dzīves kvalitāti, saistībā ar deguna operācijām. Mērķis: Metaanalīžu mērķis bija novērtēt korelāciju starp mūsdienīgu objektīvo mērījumu un subjektīvo deguna obstrukcijas sajūtu, kas ietekmē deguna elpceļus pēc deguna operācijas. Materiāli un metodes: Tika veikta sistemātiska literatūras analīze no zinātniskiem rakstiem angļu valodā, kuros tika apskatīta korelācija starp objektīviem mērījumiem un subjektīviem deguna elpceļu obstrukcijas simptomiem pēcoperatīvajā periodā. Pētījuma autore veica 23 zinātnisko rakstu analīzi. Pētījuma re…

Small Bowel Perforations: What the Radiologist Needs to Know

2016

The incidence of small bowel perforation is low but can develop from a variety of causes including Crohn disease, ischemic or bacterial enteritis, diverticulitis, bowel obstruction, volvulus, intussusception, trauma, and ingested foreign bodies. In contrast to gastroduodenal perforation, the amount of extraluminal air in small bowel perforation is small or absent in most cases. This article will illustrate the main aspects of small bowel perforation, focusing on anatomical reasons of radiological findings and in the evaluation of the site of perforation using plain film, ultrasound, and multidetector computed tomography equipments. In particular, the authors highlight the anatomic key notes…

Repeated pull-through surgery for complicated Hirschsprung's disease--principles derived from clinical experience.

2007

Abstract Background In some patients, an initial pull-through procedure for Hirschsprung's disease fails, and obstructive symptoms persist or recur. Then a repeated pull-through operation may be necessary. Methods Seventeen patients with Hirschsprung's disease aged 2 to 9 years (median, 4.6 years) have undergone a repeated pull-through procedure because of unresponsive symptoms after an initial operation. The initial procedure was Soave in 3 patients, Rehbein in 13 patients, and Duhamel in 1 patient. Surgical revision was indicated by incomplete resection of the transition zone in 16 patients, anastomotic strictures in 9 patients, and fistulas in 2 patients. All 17 patients have undergone R…

Reverse rotation of the right kidney associated with vascular anomaly producing ipsilateral ureteropelvic junction obstruction.

2009

Position paper on nasal obstruction: evaluation and treatment.

2018

Nasal obstruction (NO) is defined as the subjective perception of discomfort or difficulty in the passage of air through the nostrils. It is a common reason for consultation in primary and specialized care and may affect up to 30%-40% of the population. It affects quality of life (especially sleep) and lowers work efficiency. The aim of this document is to agree on how to treat NO, establish a methodology for evaluating and diagnosing it, and define an individualized approach to its treatment. NO can be unilateral or bilateral, intermittent or persistent and may be caused by local or systemic factors, which may be anatomical, inflammatory, neurological, hormonal, functional, environmental, …

Benign Prostatic Hyperplasia: Correlations between Receptor Density and Binding Affinity of 1-Adrenoceptors and Several Clinical Parameters

2002

The aim of the study was to determine whether relations do exist between the concentration and activity of 1-adrenoceptors, both inside the prostatic adenoma and the periurethral zone corresponding to the bladder neck, and clinical and biological parameters such as symptoms, evaluated by the American Urological Association (AUA) score, age, weight of the prostate, PSA, and the flow rate. Twenty patients with symptomatic benign prostatic hyperplasia were selected for an open prostatectomy. One gram of tissue was dissected from inside the adenoma and 1 g from the periurethral zone corresponding to the bladder neck. The 1-adrenoceptors were evaluated for the apparent dissociation constant (Kd)…