Search results for "Obstructive"

showing 10 items of 609 documents

Respiratory syncytial virus inhibits ciliagenesis in differentiated normal human bronchial epithelial cells: effectiveness of N-acetylcysteine.

2012

Persistent respiratory syncytial virus (RSV) infections have been associated with the exacerbation of chronic inflammatory diseases, including chronic obstructive pulmonary disease (COPD). This virus infects the respiratory epithelium, leading to chronic inflammation, and induces the release of mucins and the loss of cilia activity, two factors that determine mucus clearance and the increase in sputum volume. These alterations involve reactive oxygen species-dependent mechanisms. The antioxidant N-acetylcysteine (NAC) has proven useful in the management of COPD, reducing symptoms, exacerbations, and accelerated lung function decline. NAC inhibits RSV infection and mucin release in human A54…

Viral DiseasesPulmonologyChronic Obstructive Pulmonary Diseaseslcsh:MedicineMucin 5ACVirus ReplicationAcetylcysteinePulmonary Disease Chronic ObstructiveTubulinRespiratory systemlcsh:ScienceCells CulturedMultidisciplinaryInterleukin-13Microscopy VideoCell DifferentiationForkhead Transcription FactorsFree Radical Scavengersrespiratory systemHost-Pathogen InteractionLower Respiratory Tract InfectionsInfectious Diseasesmedicine.anatomical_structureInterleukin 13Medicinemedicine.symptomResearch Articlemedicine.drugDrugs and DevicesInflammationBronchiRespiratory Syncytial Virus InfectionsBiologyMicrobiologyAntiviral AgentsUpper Respiratory Tract InfectionsmedicineHumansCiliaBiologyInflammationRespiratory Syncytial Virus InfectionA549 cellMucinlcsh:RImmunityEpithelial CellsAxonemal DyneinsEpitheliumAcetylcysteineGene Expression RegulationRespiratory Syncytial Virus HumanRespiratory InfectionsImmunologyRespiratory epitheliumlcsh:QPLoS ONE
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Causal Effects of Body Mass Index on Airflow Obstruction and Forced Mid-Expiratory Flow: A Mendelian Randomization Study Taking Interactions and Age-…

2021

Obesity has complex links to respiratory health. Mendelian randomization (MR) enables assessment of causality of body mass index (BMI) effects on airflow obstruction and mid-expiratory flow. In the adult SAPALDIA cohort, recruiting 9,651 population-representative samples aged 18–60 years at baseline (female 51%), BMI and the ratio of forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC) as well as forced mid-expiratory flow (FEF25–75%) were measured three times over 20 follow-up years. The causal effects of BMI in childhood and adulthood on FEV1/FVC and FEF25–75% were assessed in predictive (BMI averaged over 1st and 2nd, lung function (LF) averaged over 2nd and 3rd fol…

Vital capacityPulmonary Disease Chronic Obstructive0302 clinical medicinePULMONARY-DISEASEMedicineLungPublic Environmental & Occupational HealthOriginal Research2. Zero hungerRISK0303 health sciencesCOPDInstrumental variableAge Factorslongitudinal cohortgenetic score3. Good healthOBESITYCohortLife course approachFemalePublic HealthPublic aspects of medicineRA1-1270Life Sciences & BiomedicineAdultbody mass index1117 Public Health and Health Services03 medical and health sciencesFEV1/FVC ratioMendelian randomizationLUNG-FUNCTION DECLINEMendelian randomizationQUALITYHumansCOPDGENOME-WIDE ASSOCIATION030304 developmental biologyScience & Technologybusiness.industryPublic Health Environmental and Occupational Healthnutritional and metabolic diseaseslung functionADULTSMendelian Randomization Analysismedicine.diseaseCross-Sectional Studies030228 respiratory systemASTHMAbusinessFOLLOW-UPBody mass indexDemographyFrontiers in Public Health
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The Flow-Volume-Measurement in Computer-Supported Lung Function Analysis

1982

For some years computers have been applied more and more in pulmonary function laboratories. On the one hand the medico-technical industry could connect older diagnostic systems with new calculators, on the other hand completely computerised lung function desks have been developed.

Vital capacitymedicine.medical_specialtybusiness.industryDiagnostic systemmedicine.diseaseObstructive lung diseaseComputer supportedPulmonary function testingFlow (mathematics)Volume measurementInternal medicinemedicineCardiologybusinessLung function
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Chronic Adult Hydrocephalus

1974

Knowledge of Wallerian degeneration began in 1852 and, following experimental research on degeneration and regeneration of interrupted nerves, surgeons realized that reinnervation of end organs depended on growth of axons through the interrupted area of nerve. Therefore surgeons tried to reanastomose the stumps. Failures of reinnervation could not be blamed on lack of axoplasma metabolism and flow from cell body to suture line because the clinical observation of amputation neuromas and their constant recurrence demonstrated the unfailing delivery of axoplasma by the nerve cell body; at times to the deep concern of the surgeon, and the constant pain of the patient. The electron microscope sh…

Wallerian degenerationmedicine.medical_specialtymedicine.medical_treatmentObstructive hydrocephalusDegeneration (medical)Pressure rangeInternal medicineMedicineNeurochemistryAxonCsf shuntbusiness.industryVentricular dilatationRegeneration (biology)medicine.diseasenervous system diseasesHydrocephalusSurgerymedicine.anatomical_structureAxoplasmAmputationNormal csf pressureCardiologySubarachnoid spacebusinessReinnervation
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Bone marrow-derived progenitors are greatly reduced in patients with severe COPD and low-BMI.

2009

Chronic obstructive pulmonary disease (COPD) patients have reduced circulating hemopoietic progenitors. We hypothesized that severity of COPD parallels the decrease in progenitors and that the reduction in body mass index (BMI) could be associated with more severe bone marrow dysfunction. We studied 39 patients with moderate to very severe COPD (18 with low-BMI and 21 with normal-BMI) and 12 controls. Disease severity was associated to a greater reduction in circulating progenitors. Proangiogenetic and inflammatory markers correlated with disease severity parameters. Compared to normal-BMI patients, low-BMI patients showed: greater reduction in circulating progenitors; higher VEGF-A, VEGF-C…

aged; analysis of variance; antigens; blood; blood cell count; body mass index; bone marrow transplantation; case-control studies; cd; chronic obstructive; chronic obstructive pulmonary disease; colony-forming units assay; creatine kinase; cytokines; endothelial cells; enzyme-linked immunosorbent assay; fat-free mass; female; humans; intercellular signaling peptides and proteins; lactate dehydrogenases; low-bmi copd; male; metabolism; methods; middle aged; normal-bmi copd; physiology; physiopathology/surgery; pulmonary disease; severity of illness index; statistics as topicMalePathologyPhysiologyStatistics as TopicCD34GastroenterologySeverity of Illness IndexBody Mass IndexPulmonary Disease Chronic Obstructiveantigenslow-bmi copdnormal-bmi copdCreatine Kinasepulmonary diseaseBone Marrow TransplantationCOPDchronic obstructiveGeneral NeuroscienceRespiratory diseaseMiddle Agedcdfat-free massHaematopoiesismedicine.anatomical_structurephysiopathology/surgeryCytokinesIntercellular Signaling Peptides and ProteinsFemalePulmonary and Respiratory Medicinemedicine.medical_specialtyEnzyme-Linked Immunosorbent Assaymacromolecular substancesSettore MED/10 - Malattie Dell'Apparato Respiratoriochronic obstructive pulmonary diseasemethodsColony-Forming Units AssayChronic obstructive pulmonary disease low-BMI COPD normal-BMI COPD fat-free massbloodAntigens CDInternal medicineSeverity of illnessmedicineHumansProgenitor cellLactate DehydrogenasesAgedAnalysis of Variancebusiness.industryCase-control studyEndothelial Cellsmedicine.diseaseBlood Cell CountCase-Control StudiesBone marrowbusinessmetabolismRespiratory physiologyneurobiology
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<p>Memory performances and personality traits in mothers of children with obstructive sleep apnea syndrome</p>

2019

Background Chronic diseases in pediatric age have been identified as stressful risk factors for parents. Studies on caregivers have documented the impact of chronic parenting stress on emotion and cognition. Aim To investigate the differences between a group of mothers of children affected by obstructive sleep apnea syndrome (OSAS) for at least 4 years and a group of mothers of typically developing children (TDC) in relation to parental stress, self-esteem, locus of control, and memory performances. Methods A group of 86 mothers (mean age 35.6±4.9, ranged between 32 and 41 years) of children with OSAS diagnosis, and a group of 52 mothers of TDC (mean age 35.9±4.2, ranged between 32 and 41 y…

business.industry05 social sciencesRespiratory diseaseCognitionmedicine.disease050105 experimental psychologyStress levelObstructive sleep apnea03 medical and health sciencesPsychiatry and Mental health0302 clinical medicineLocus of controlStress (linguistics)medicine0501 psychology and cognitive sciences030212 general & internal medicineStress conditionsBig Five personality traitsbusinessGeneral PsychologyClinical psychologyPsychology Research and Behavior Management
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Immunopositivity of heat shock protein 60 as a biomarker of bronchial carcinogenesis

2005

business.industryBronchial NeoplasmsBronchiChaperonin 60hsp60medicine.disease_causePulmonary Disease Chronic ObstructiveOncologyCarcinoma Basal CellHeat shock proteinCancer researchmedicineBiomarkers TumorBiomarker (medicine)HumansCarcinogenesisbusiness
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Obstructive sleep apnea: arterial oxygen desaturation coincides with increases in systemic oxidative stress markers measured with continuous monitori…

2007

business.industryContinuous monitoringArterial oxygenSleep apneaGlutathionemedicine.diseaseMalondialdehydemedicine.disease_causeBiochemistryObstructive sleep apneachemistry.chemical_compoundchemistryPhysiology (medical)AnesthesiamedicinebusinessOxidative stressFree Radical Biology and Medicine
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Effect of rapid maxillary expansion on sleep apnea-hypopnea syndrome in growing patients. A meta-analysis.

2019

Background Changes produced in the upper airway after rapid maxillary expansion makes this procedure a therapeutic option for treating sleep apnea-hypopnea syndrome (SAHS) in children. The objective of this systematic review and meta-analysis was to analyze the evidence available for the effects of rapid maxillary expansion (RME) on SAHS, analyzing changes produced in oximetric variables: apnea-hypopnea index (AHI); oxygen saturation (SO2); sleep efficiency (SE), total sleep time (TST), percentage of rapid eye movement (REM) phase; and arousal index (AI). Material and Methods An electronic search was conducted in the PubMed, Scopus, Embase, and Cochrane databases, and in grey literature (Op…

business.industrySleep Apnea Hypopnea SyndromeSleep apneaOrthodonticsReview030206 dentistry:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseObstructive sleep apnea03 medical and health sciences0302 clinical medicineSample size determinationMeta-analysisAnesthesiaUNESCO::CIENCIAS MÉDICASMedicineRapid maxillary expansionAirwaybusinessGeneral Dentistry030217 neurology & neurosurgeryOxygen saturation (medicine)Journal of clinical and experimental dentistry
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Signal processing procedures for the evaluation of the cardiovascular effects in the obstructive sleep apnea syndrome

2002

A new index, the cross-power index (CPI), is proposed to quantify the severity of obstructive sleep apnea syndrome (OSAS) in terms of its cardiovascular effects. On the basis of the influences that recurring drops in oxygen saturation have on systolic blood pressure variability of OSAS patients, CPI is defined as the integral of the cross-spectrum modulus between systolic blood pressure and oxygen saturation. In a test group of 22 subjects, CPI correctly identified all 15 OSAS patients included in the pool. Moreover, evaluation of CPI in six OSAS patients sleeping with and without a CPAP (continuous positive airway pressure) device demonstrated that CPAP treatment substantially reduced the …

business.industryTest groupmedicine.medical_treatmentHemodynamicsSettore MED/10 - Malattie Dell'Apparato Respiratoriomedicine.diseasenervous system diseasesrespiratory tract diseasesObstructive sleep apneaBlood pressureAnesthesiaMedicineCpap treatmentPatient treatmentContinuous positive airway pressurebusinessCardiology and Cardiovascular MedicineSoftwareOxygen saturation (medicine)
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