Search results for "Odds"

showing 10 items of 1327 documents

Parental occupational exposure to organic solvents and anencephaly in Mexico

2009

Objective: To assess the relationship between parental occupational exposure to organic solvents, and the risk of anencephaly in Mexico. Methods: A case-control study was conducted based on the registers of the Epidemiological Surveillance System for Neural Tube Defects in Mexico; 151 cases of anencephaly of ≥20 weeks’ gestation were included. A control, born alive and without any apparent congenital malformations at birth, was selected for each case in the same maternity service in which the case was born. Information on occupational exposures, lifestyle habits, reproductive history, use of medicines, supplementation with multivitamins and folic acid, was obtained by a general questionnair…

AdultMalemedicine.medical_specialtyExposición profesional:Chemicals and Drugs::Chemical Actions and Uses::Specialty Uses of Chemicals::Solvents [Medical Subject Headings]Logistic regressionOccupational safety and healthOccupational medicineRisk FactorsOccupational ExposureEnvironmental healthAnencephaly:Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Maternal Exposure [Medical Subject Headings]:Diseases::Congenital Hereditary and Neonatal Diseases and Abnormalities::Congenital Abnormalities::Abnormalities Severe Teratoid::Anencephaly [Medical Subject Headings]medicineHumansMexicoAnencephalyPregnancybusiness.industryPublic Health Environmental and Occupational Health:Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Occupational Exposure [Medical Subject Headings]Odds ratioOccupational exposureAnencefaliamedicine.diseaseSolventesSurgeryB vitamins:Geographicals::Geographic Locations::Americas::North America::Mexico [Medical Subject Headings]Maternal ExposureCase-Control StudiesPaternal ExposureSolventsGestationFemalebusinessOccupational and Environmental Medicine
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Failure to renew prescriptions for gastroprotective agents to patients on continuous nonsteroidal anti-inflammatory drugs increases rate of upper gas…

2013

Patients with risk factors for gastrointestinal (GI) disorders who continuously use nonsteroidal anti-inflammatory drugs (NSAIDs) also should take gastroprotective agents (GPAs), such as proton pump inhibitors (PPIs). However, it is not clear how many physicians continue to prescribe GPAs to these patients, and whether stopping the GPA prescription increases GI complications.We performed a retrospective, observational, longitudinal study using a validated electronic database of representative general practitioners in France. We analyzed data for 1856 patients at risk for GI events (65 y, past history of GI ulcer, or receiving antiplatelet agents) who received prescriptions for an NSAID and …

AdultMalemedicine.medical_specialtyGastrointestinal DiseasesLogistic regressionGastrointestinal AgentsInternal medicinemedicineHumansLongitudinal StudiesMedical prescriptionAdverse effectAgedRetrospective StudiesAged 80 and overHepatologybusiness.industryHazard ratioAnti-Inflammatory Agents Non-SteroidalGastroenterologyRetrospective cohort studyOdds ratioMiddle AgedConfidence intervalSurgeryFemaleFranceComplicationbusinessClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
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Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis

2006

Objectives: Three recent studies revealed a haplotypic association of alcohol dependence with the gene encoding the {alpha}2 subunit of the {gamma}-aminobutyric acid type A (GABAA) receptor (GABRA2). The present study examined whether variation of the GABRA2 gene confers susceptibility to different subtypes of alcohol dependence in the German population. Methods: A total of 257 German alcohol-dependent patients and 88 healthy population controls were genotyped for six single-nucleotide polymorphisms covering the middle part and the 3′ end of GABRA2. Allelic, genotypic and haplotypic comparisons were done for subgroups of alcohol-dependent patients with a presumed high genetic load. Results:…

AdultMalemedicine.medical_specialtyGenotypeGene DosagePolymerase Chain ReactionPolymorphism Single NucleotideGastroenterologyLinkage DisequilibriumGABRG1Internal medicineGeneticsmedicineGenetic predispositionHumansGABRA2AlleleAllelesBiological PsychiatryGenetics (clinical)GeneticsbiologyHaplotypeAlcohol dependenceOdds ratioReceptors GABA-AGenetic loadAlcoholismPsychiatry and Mental healthHaplotypesCase-Control Studiesbiology.proteinFemalePsychiatric Genetics
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Retinol-binding protein 4: a new marker of virus-induced steatosis in patients infected with hepatitis C virus genotype 1.

2008

Retinol-binding protein 4 (RBP4) is an adipocytokine associated with insulin resistance (IR). We tested serum levels of RBP4 to assess its link with steatosis in patients with genotype 1 chronic hepatitis C (CHC) or nonalcoholic fatty liver disease (NAFLD). Nondiabetic patients with CHC (n = 143) or NAFLD (n = 37) were evaluated by liver biopsy and anthropometric and metabolic measurements, including IR by the homeostasis model assessment. Biopsies were scored by Scheuer classification for CHC, and Kleiner for NAFLD. Steatosis was tested as a continuous variable and graded as absent-mild <30%, or moderate-severe > or =30%. Thirty nondiabetic, nonobese blood donors served as controls. …

AdultMalemedicine.medical_specialtyGenotypeHepatitis C virusHepacivirusSettore MED/08 - Anatomia Patologicamedicine.disease_causeGastroenterologySeverity of Illness IndexInsulin resistanceRisk FactorsInternal medicineNonalcoholic fatty liver diseasemedicinesteatosisHumansRetinol-binding protein 4 .Retinol binding protein 4Settore MED/12 - GastroenterologiaHepatologybiologymedicine.diagnostic_testOdds ratioHepatologyHepatitis C ChronicMiddle Agedmedicine.diseaseFatty LiverLogistic ModelsLiverLiver biopsyImmunologybiology.proteinFemaleSteatosisRetinol-Binding Proteins PlasmaBiomarkers
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Evidence for the importance of the human dopamine transporter gene for withdrawal symptomatology of alcoholics in a German population

2002

Two new polymorphisms in the 3' untranslated region (3'UTR) of the dopamine transporter (DAT1) gene, adjacent to the known variable number of tandem repeats (VNTR) polymorphism, have been investigated in the present population-based association study including 351 alcoholics and 336 controls. The DraI restriction site was not polymorphic in our population. The G2319A polymorphism was not significantly different with respect to genotype or allele distribution between alcoholics and controls. Subsequently, in individuals with VNTR homozygosity for the ten repeat allele, we found a higher prevalence of A/A homozygosity in patients with seizure history (P = 0.001, odds ratio (OR) = 7.913), with…

AdultMalemedicine.medical_specialtyGenotypeMolecular Sequence DataPopulationNerve Tissue ProteinsGene FrequencyPolymorphism (computer science)GermanyInternal medicineGenotypeOdds RatiomedicineHumansAlleleeducationDopamine transporterGeneticsDopamine Plasma Membrane Transport Proteinseducation.field_of_studyChi-Square DistributionMembrane GlycoproteinsPolymorphism GeneticbiologyGeneral NeuroscienceMembrane Transport ProteinsOdds ratioMiddle AgedSubstance Withdrawal SyndromeAlcoholismRestriction siteVariable number tandem repeatEndocrinologybiology.proteinFemaleNeuroscience Letters
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Stage of change and motivation to healthier lifestyle in non-alcoholic fatty liver disease.

2013

Backgrounds & Aims: Healthy diet and physical activity are the treatment cornerstones of non-alcoholic fatty liver disease (NAFLD); their effectiveness is however limited by difficulties in implementing lifestyle changes. We aimed at determining the stage of change and associated psychological factors as a prerequisite to refine strategies to implement behavior changes. Methods: We studied 138 consecutive NAFLD patients (73% male, age 19-73 years). The diagnosis was confirmed by liver biopsy in 64 cases (steatohepatitis, 47%). All cases completed the validated EMME-3 questionnaire, consisting of two parallel sets of instruments (for diet and physical activity, respectively) and providing st…

AdultMalemedicine.medical_specialtyHealth BehaviorDiseaseMotor ActivityLogistic regressionPsychological factorsDIETNAFLD. LIFESTYLEYoung Adult03 medical and health sciencesWEIGHT LOSS0302 clinical medicineHumansNON-ALCOHOLIC FATTY LIVER DISEASEMedicine030212 general & internal medicineYoung adultLife StyleAgedHepatologybusiness.industryPhysical activityBehavior changeFatty liverTranstheoretical modelLIFESTYLE DETERMINANTSMOTIVATIONOdds ratioMiddle Agedmedicine.diseaseLifestyle3. Good healthFatty LiverHealthy dietPhysical therapyFemale030211 gastroenterology & hepatologysense organsSteatohepatitisbusinessDemography
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A Web-Based Telemanagement System for Improving Disease Activity and Quality of Life in Patients With Complex Inflammatory Bowel Disease: Pilot Rando…

2018

Background: The reported efficacy of telemedicine in patients with inflammatory bowel disease (IBD) is inconsistent among studies, and data for complex IBD are lacking. Objective: We aimed to evaluate the impact of remote monitoring using a Web system—Telemonitorizacion de la Enfermedad de Crohn y Colitis Ulcerosa or Telemonitoring of Crohn’s Disease and Ulcerative Colitis (TECCU)—as compared to standard care and telephone care on health outcomes and health care in patients with complex IBD. Methods: We performed a 3-arm randomized controlled trial. Adult patients with IBD who received immunosuppressants and biological agents were recruited from the IBD Unit of a tertiary university hospita…

AdultMalemedicine.medical_specialtyHealth InformaticsPilot ProjectsInflammatory bowel diseaselaw.invention03 medical and health sciencesYoung Adult0302 clinical medicineRandomized controlled trialQuality of lifelawinflammatory bowel diseaseInternal medicineHealth caremedicineHumansAdverse effectinformation and communication technologyulcerative colitisInternetOriginal Paperbusiness.industryCrohn diseaseOdds ratioMiddle Agedmedicine.diseaseInflammatory Bowel DiseasesUlcerative colitisTelemedicineClinical trial030220 oncology & carcinogenesisQuality of Lifee-health030211 gastroenterology & hepatologyColitis UlcerativeFemaletelemedicinebusinessJournal of medical Internet research
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Association Between Physical Activity and Odds of Chronic Conditions Among Workers in Spain

2020

Introduction:\ud \ud Prevention of chronic conditions is a major public health challenge, and achieving minimum recommended levels of physical activity aids in reaching this objective. The aim of our study was to investigate whether levels of physical activity were associated with the prevalence of common chronic conditions among the Spanish workforce.\ud \ud Methods:\ud \ud We retrieved data from the Spanish National Health Survey 2017 (N = 9,695) in which the mean age of participants was 44.4 (standard deviation, 10.4 y), and 47.4% were women. Workers self-reported a set of 6 chronic conditions (ie, chronic low-back pain, chronic neck pain, diabetes, hypertension, depression, and anxiety)…

AdultMalemedicine.medical_specialtyHealth StatusLogistic regression01 natural sciencesOddsBody Mass Index03 medical and health sciences0302 clinical medicineDiabetes mellitusmedicineOdds RatioPrevalenceHumans030212 general & internal medicine0101 mathematicsExerciseDepression (differential diagnoses)Original Researchbusiness.industryHealth PolicyPublic health010102 general mathematicsPublic Health Environmental and Occupational HealthOdds ratioMiddle Agedmedicine.diseaseHealth SurveysCross-Sectional StudiesSpainChronic DiseaseAnxietyFemalemedicine.symptombusinessBody mass indexDemography
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Thyroid hormone receptor alpha gene variants increase the risk of developing obesity and show gene-diet interactions.

2013

Thyroid hormone receptor-beta resistance has been associated with metabolic traits. THRA gene sequencing of an obese woman (index case) who presented as empirical thyroid hormone receptor-α (THRA) resistance, disclosed a polymorphism (rs12939700) in a critical region involved in TRα alternative processing.THRA gene variants were evaluated in three independent europid populations (i) in two population cohorts at baseline (n=3417 and n=2265), 6 years later (n=2139) and (ii) in 4734 high cardiovascular risk subjects (HCVR, PREDIMED trial).The minor allele of the index case polymorphism (rs12939700), despite having a very low frequency (4%), was significantly associated with higher body mass in…

AdultMalemedicine.medical_specialtyHeterozygoteEndocrinology Diabetes and MetabolismPopulationMedicine (miscellaneous)Polymorphism Single NucleotideBody Mass IndexHypothyroidismRisk FactorsInternal medicinemedicineHumansGenetic Predisposition to DiseaseObesityeducationeducation.field_of_studyNutrition and DieteticsThyroid hormone receptorbusiness.industryThyroidOdds ratioMiddle Agedmedicine.diseaseObesityDietary FatsMinor allele frequencymedicine.anatomical_structureEndocrinologyCross-Sectional StudiesCardiovascular DiseasesSpainFemaleFranceInsulin ResistancebusinessEnergy IntakeBody mass indexHormoneThyroid Hormone Receptors alphaInternational journal of obesity (2005)
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CC chemokine receptor 5 polymorphism in Italian patients with Beḩet's disease

2012

OBJECTIVE: To evaluate the potential role of CC chemokine receptor 5 (CCR5)Δ32 polymorphism in the susceptibility to and clinical expression of Behcet's disease (BD) in a cohort of Italian patients. METHODS: One hundred and ninety-six consecutive Italian patients satisfying the ISG criteria for BD were followed up for 8 years, and 180 healthy age- and sex-matched blood donors were molecularly genotyped for the CCR5Δ32 polymorphism. A standard microlymphocytotoxicity technique was used to serotype HLA-B51. The patients were subgrouped on the basis of the presence or absence of clinical manifestations. RESULTS: The distribution of the CCR5Δ32 genotype differed between BD patients and controls…

AdultMalemedicine.medical_specialtyHeterozygoteReceptors CCR5Behcet's disease CCR5 polymorphismBehcet's diseaseGastroenterologyRheumatologyGeneticGene FrequencyInternal medicineGenotypeReceptorsMedicineHumansPharmacology (medical)Genetic Predisposition to DiseaseAllelePolymorphismAllele frequencyPolymorphism Geneticbusiness.industryBehcet SyndromeHomozygoteCase-control studyOdds ratiomedicine.diseaseBeḩet's disease; CC chemokine receptor 5 Δ32 olymorphism; Chemokines; Disease manifestations; Adult; Behcet Syndrome; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; HLA-B Antigens; Heterozygote; Homozygote; Humans; Italy; Male; Polymorphism Genetic; Receptors CCR5; Rheumatology; Pharmacology (medical)Adult; Behcet Syndrome; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; HLA-B Antigens; Heterozygote; Homozygote; Humans; Italy; Male; Polymorphism Genetic; Receptors CCR5ItalyHLA-B AntigensCase-Control StudiesImmunologyCohortFemalebusinessCC chemokine receptorsCCR5
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