Search results for "Ofili"

Nomina e responsabilità degli amministratori di societàin mano pubblica: note e profili distintivi dal regime generale.

2011

Influence of aryl hydrocarbon- (Ah) receptor and genotoxins on DNA repair gene expression and cell survival of mouse hepatoma cells

2009

The aryl hydrocarbon receptor (AhR) mediates toxicity of a variety of environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) and dioxins. However, the underlying mechanisms and genetic programmes regulated by AhR to cause adverse effects but also to counteract poisoning are still poorly understood. Here we analysed the effects of two AhR ligands, benzo[a]pyrene (B[a]P), a DNA damaging tumour initiator and promotor and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a pure tumour promoter, on cell survival and on nucleotide excision repair (NER) gene expression. NER deals with so called "bulky" DNA adducts including those generated by enzymatically activated B[a]P. Therefore, t…

Heterogeneity within and between primary colorectal carcinomas and matched metastases as revealed by analysis of Ki-ras and p53 mutations

2004

Analysis of the genetic status of Ki-ras and p53 in primary colorectal carcinomas and matched colorectal liver metastasis from 30 patients reveals an overall heterogeneity both within and between the two tumoral tissues. Both genes were found mutated with a similar frequency in both tissues; however, identical mutations in primary tumor and matched metastasis were found less frequently in the case of the Ki-ras than the p53 gene. Only in three cases the same p53 and Ki-ras mutations found in the primary tumor were found also in the metastasis. In several metastatic specimens the DNA bearing a mutation detected also in the primary tumor appears significantly less abundant than the wild-type …

Metiljasmonāta ietekme uz Pinus sylvestris L. gēnu ekspresijas profilu

2016

Šajā pētījumā noskaidrojām metiljasmonāta ietekmi uz parastās priedes gēnu ekspresijas profilu ar mērķi pārbaudīt tā potenciālu inducētas rezistences veidošanā. Divgadīgus viena klona parastās priedes stādus apstrādājām ar 10 mM metiljasmonāta un pēc divām nedēļām ievācām skuju paraugus. No iegūtajiem paraugiem izdalījām RNS un veicām nāk paaudzes sekvencēšanu ar Ion Torrent PGM platformu, kā arī RT-PCR ekspresijas pārbaudi atsevišķiem gēniem. Sekvencēšanā iegūtos datus analizējām ar RNA-Seq iegūstot paraugos ekspresēto gēnu profilu. Šos rezultātus apkopojām, veidojot gēnu tīklu un iegūstot funkcionalitātes anotācijas. Noskaidrojām, ka apstrāde novirza metabolisma orientāciju no augšanas un…

Welfare locale e piani di zona. Modelli, interventi di comunità e buone prassi

2008

Pedofilia la femminile. Una rassegna di contributi teorico-clinici tra contesti evolutivi traumatici, dilemmi relazionali e setting riparativi

2012

Characterization and transcription studies of a phytochelatin synthase gene from the solitary tunicate Ciona intestinalis exposed to cadmium.

2014

The major thiol-containing molecules involved in controlling the level of intracellular ROS in eukaryotes, acting as a nonenzymatic detoxification system, are metallothioneins (MTs), glutathione (GSH) and phytochelatins (PCs). Both MTs and GSH are well-known in the animal kingdom. PC was considered a prerogative of the plant kingdom but, in 2001, a phytochelatin synthase (PCS) gene was described in the nematode Caenorhabditis elegans; additional genes encoding this enzyme were later described in the earthworm Eisenia fetida and in the parasitic nematode Schistosoma mansoni but scanty data are available, up to now, for Deuterostomes. Here, we describe the molecular characteristics and transc…

Il Piacere Tossico.Tossicofilie, tossicomanie, tossicodipendenze: dalla psicopatologia individuale alla psicologia collettiva

2005

Tema principale è l'analisi della dipendenza tossicomanica, secondo una prospettiva psicoanalitica

Application of an immunoproteomic approach to detect anti-profilin antibodies in sera of paritaria judaica allergic patients

2011

Pollen from grasses, weeds, and trees constitutes one of the main sources of inhalant allergens frequently associated with seasonal patterns of allergic diseases. Pollen allergens show some analogies in the amino acids sequence which determine immunological similarity and cross reactivity. Parietaria judaica (P.j) pollen represents one of the main sources of allergens in the Mediterranean area and its major allergens have already been identified (Par j 1 and Par j 2). Recently, has been also described a minor allergen, profilin (Par j 3), an allergen present in pollen of trees, grasses and weeds. Allergenic plant profilins constitute a highly conserved family with sequence identities of 70%…

Regulatory networks underlying mycorrhizal development delineated by genome-wide expression profiling and functional analysis of the transcription fa…

2017

Background: Ectomycorrhizal (ECM) fungi develop a mutualistic symbiotic interaction with the roots of their host plants. During this process, they undergo a series of developmental transitions from the running hyphae in the rhizosphere to the coenocytic hyphae forming finger-like structures within the root apoplastic space. These transitions, which involve profound, symbiosis-associated metabolic changes, also entail a substantial transcriptome reprogramming with coordinated waves of differentially expressed genes. To date, little is known about the key transcriptional regulators driving these changes, and the aim of the present study was to delineate and functionally characterize the trans…