Search results for "Oncocytoma"

showing 3 items of 13 documents

Classification of Renal Cell Carcinoma Based on Morphologic and Cytogenetic Correlations

1995

Typing or classification of renal cell carcinomas — a term introduced by Murphy and Mostofi in 1965 (1) — has been a debatable field since Grawitz (2) introduced the term hypernephroma in 1883. Grawitz postulated a hypernephrogenic origin of renal cancers, whose cells exhibit a light cytoplasm. During recent decades it has become customary to view renal cell carcinoma as a complex entity. Despite support for this idea by the World Health Organization (3) a morphological subtyping of renal cell carcinoma has not been recognized until recently. In 1986 Thoenes et al. (4) proposed a new pathomorphological subtyping of epithelial renal cell tumors, renal cell carcinoma (RCC) and adenoma (RCA), …

Pathologymedicine.medical_specialtyAdenomaCellRenal cancersBiologyurologic and male genital diseasesmedicine.diseasefemale genital diseases and pregnancy complicationsSubtypingClear cell renal cell carcinomamedicine.anatomical_structureRenal cell carcinomamedicineRenal oncocytomaneoplasmsClear cell
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Mitochondrial and chromosomal DNA alterations in human chromophobe renal cell carcinomas

1992

Renal cell tumours are characterized by the loss of chromosome 3p and trisomy of 5q segments (common, non-papillary renal cell carcinoma), or by trisomy of chromosomes 7 and 17 and loss of the Y chromosome (papillary renal cell carcinoma), or by random karyotype changes and mitochondrial DNA alterations (renal oncocytoma). We have studied by means of RFLP analysis the genomic and mitochondrial DNA in 11 chromophobe renal cell carcinomas, which have a unique morphology among kidney cancers. We found a loss of the constitutional heterozygosity at chromosomal regions 3p, 5q, 17p, and 17q, a combination of allelic losses that has not been found in other types of renal cell tumours. Three of the…

Pathologymedicine.medical_specialtyMitochondrial DNAChromophobe Renal Cell CarcinomaChromophobe cellBiologyurologic and male genital diseasesDNA MitochondrialChromosomesPathology and Forensic MedicineLoss of heterozygosityRenal cell carcinomamedicineHumansRenal oncocytomaCarcinoma Renal CellChromosome AberrationsKidneyStaining and LabelingPapillary renal cell carcinomasDNA Neoplasmmedicine.diseaseKidney NeoplasmsBlotting Southernmedicine.anatomical_structurePolymorphism Restriction Fragment LengthThe Journal of Pathology
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Novel Monoclonal Antibody 138H11 Against Human γ-Glutamyl-Transferase: Classification, Histogenesis and Immunoscintigraphy of Renal Tumors

1992

Monoclonal antibody (mAb) 138H11 was produced against human gamma-glutamyl transferase as a molecular probe for renal cancer. Immunohistochemical analyses of mAb 138H11 revealed its reaction with the brush border of normal kidney cortex as well as with clear cell and chromophilic renal carcinomas. In contrast, renal oncocytomas, chromophobic carcinomas, and Duct-Bellini carcinomas were negative for this antibody. These results support a new approach for the histogenesis and classification of renal tumors. Immunoscintigraphy of tumor bearing human kidneys, perfused with 99Tcm-labeled mAb 138H11 after nephrectomy, showed enrichment of 138H11 in three of three clear cell carcinomas that was up…

Pathologymedicine.medical_specialtybusiness.industrymedicine.medical_treatmentHistogenesisurologic and male genital diseasesmedicine.diseaseNephrectomyImmunoscintigraphyRenal cell carcinomaClear cell carcinomamedicineImmunohistochemistryOncocytomabusinessClear cell
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