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RESEARCH PRODUCT
Novel Monoclonal Antibody 138H11 Against Human γ-Glutamyl-Transferase: Classification, Histogenesis and Immunoscintigraphy of Renal Tumors
M. TauberP. FischerW. BoeckmannJürgen E. ScherberichStephan StörkelS. WeierRichard P. Baumsubject
Pathologymedicine.medical_specialtybusiness.industrymedicine.medical_treatmentHistogenesisurologic and male genital diseasesmedicine.diseaseNephrectomyImmunoscintigraphyRenal cell carcinomaClear cell carcinomamedicineImmunohistochemistryOncocytomabusinessClear celldescription
Monoclonal antibody (mAb) 138H11 was produced against human gamma-glutamyl transferase as a molecular probe for renal cancer. Immunohistochemical analyses of mAb 138H11 revealed its reaction with the brush border of normal kidney cortex as well as with clear cell and chromophilic renal carcinomas. In contrast, renal oncocytomas, chromophobic carcinomas, and Duct-Bellini carcinomas were negative for this antibody. These results support a new approach for the histogenesis and classification of renal tumors. Immunoscintigraphy of tumor bearing human kidneys, perfused with 99Tcm-labeled mAb 138H11 after nephrectomy, showed enrichment of 138H11 in three of three clear cell carcinomas that was up to seven fold greater than that in the remaining normal kidney cortex. In contrast, examination of an oncocytoma did not reveal any uptake of labeled mAb 138H11. Our results suggest a possible use of mAb 138H11 for pre-, intra-, and postsurgical diagnosis of primary renal tumors and metastases that may indicate further choices of therapy.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-01-01 |