Search results for "Opera"
showing 10 items of 8665 documents
Integrated care pathways for airway diseases (AIRWAYS-ICPs)
2014
International audience; The objective of Integrated Care Pathways for Airway Diseases (AIRWAYS-ICPs) is to launch a collaboration to develop multi-sectoral care pathways for chronic respiratory diseases in European countries and regions. AIRWAYS-ICPs has strategic relevance to the European Union Health Strategy and will add value to existing public health knowledge by: 1) proposing a common framework of care pathways for chronic respiratory diseases, which will facilitate comparability and trans-national initiatives; 2) informing cost-effective policy development, strengthening in particular those on smoking and environmental exposure; 3) aiding risk stratification in chronic disease patien…
Reliability of genomic variants across different next-generation sequencing platforms and bioinformatic processing pipelines
2021
Abstract Background Next Generation Sequencing (NGS) is the fundament of various studies, providing insights into questions from biology and medicine. Nevertheless, integrating data from different experimental backgrounds can introduce strong biases. In order to methodically investigate the magnitude of systematic errors in single nucleotide variant calls, we performed a cross-sectional observational study on a genomic cohort of 99 subjects each sequenced via (i) Illumina HiSeq X, (ii) Illumina HiSeq, and (iii) Complete Genomics and processed with the respective bioinformatic pipeline. We also repeated variant calling for the Illumina cohorts with GATK, which allowed us to investigate the e…
Effect of adolescent exposure to WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference.
2009
The present study employs a conditioned place preference procedure (CPP) to examine the effects of exposure to the cannabinoid agonist WIN 55212-2 (WIN) (0.1 and 0.5mg/kg) during adolescence on the reinforcing properties of +/-3,4-methylenedioxymetamphetamine hydrochloride (MDMA) (1.25 and 2.5mg/kg) in mice. On postnatal day (PD) 27, animals received a daily injection of the assigned treatment on 5 consecutive days, and three days later the place conditioning procedure was initiated (PD 35). The results suggest that pre-exposure to cannabinoids strengthens the properties of MDMA and favors reinstatement of the craving for the drug, which endorses the gateway hypothesis.
CB1 cannabinoid receptor-mediated aggressive behavior
2013
This study examined the role of cannabinoid CB1 receptors (CB1r) in aggressive behavior. Social encounters took place in grouped and isolated mice lacking CB1r (CB1KO) and in wild-type (WT) littermates. Cognitive impulsivity was evaluated in the delayed reinforcement task (DRT). Gene expression analyses of monoaminooxidase-A (MAO-A), catechol-o-methyl-transferase (COMT), 5-hydroxytriptamine transporter (5-HTT) and 5-HT1B serotonergic receptor (5HT1Br) in the median and dorsal raphe nuclei (MnR and DR, respectively) and in the amygdala (AMY) were performed by real time-PCR. Double immunohistochemistry studies evaluated COMT and CB1r co-localization in the raphe nuclei and in the cortical (AC…
DIFFERENT ABILITY OF TRIFLUOPERAZINE TO INHIBIT AGONIST-INDUCED CONTRACTION OF LUNG PARENCHYMA STRIPS FROM CONTROL AND SENSITIZED GUINEA-PIGS
1988
Abstract There is increasing interest in the therapeutic potential of calcium antagonists in asthma. Among them the use of calmodulin antagonists deserves consideration. In the present work the effect of trifluoperazine on contractions generated by different mechanisms (CaCl2, KCl, acetylcholine, histamine and 5-hydroxytryptamine) in lung parenchyma strip isolated from control and actively sensitized guinea-pigs has been studied. Trifluoperazine produced both in unsensitized and sensitized lung strips, a concentration-dependent, right, downward displacement of the concentration-response curves to the agonists used, although the sensitization procedure resulted in a potentiation in the abili…
Pandemic Prevention and Personality Psychology: Gender Differences in Preventive Health Behaviors during COVID-19 and the Roles of Agreeableness and …
2022
One of the greatest public health crises in recent times, the COVID-19 pandemic, has come with a myriad of challenges in terms of health communication and public cooperation to prevent the spread of the disease. Understanding which are the key determinants that make certain individuals more cooperative is key in effectively tackling pandemics and similar future challenges. In the present study (N = 800), we investigated whether gender differences in compliance with preventive health behaviors (PHB) at the onset of the COVID-19 pandemic could be established, and, if so, whether the personality traits of agreeableness and conscientiousness could help explain this presumed relationship. Consis…
Sustainable Farming Practices, Awareness, and Behavior in Small Farms in Brazil
2021
This paper investigates the relationship between the use of digital and non-digital sources of information on sustainable farming practices, institutional pressure and adoption of such practices by farmers in Brazilian semi-arid lands. The research uses a model based on the theory of reasoned action (TRA) and the institutional theory. Our results for a sample of 100 Brazilian farmers show that non-digital sources of information and ‘Coercive’ and ‘Normative’ pressures have a positive impact on farmers’ attitude towards and actual adoption of sustainable farming practices. However, digital sources of information such as TV and Radio do not play a significant role. In addition, pro-environmen…
Worker safety in agriculture 4.0: A new approach for mapping operator's vibration risk through Machine Learning activity recognition
2022
While being a fundamental driver of competitiveness in agroindustry, technological innovation has also introduced new critical elements related, for example, to the sustainability of the production processes as well as to the safety of workers. In such regard, the advent of the 4th industrial revolution (Agriculture 4.0) based on digitalization, is an unprecedented opportunity of rethinking the role of innovation in a new human-centric perspective. In particular, the establishment of an interconnected work environment and the augmentation of the operator’s physical, sensorial, and cognitive capabilities, are two technologies which can be effectively employed for substantially improving the …
Estimating economic severity of Air Traffic Flow Management regulations
2021
The development of trajectory-based operations and the rolling network operations plan in European air traffic management network implies a move towards more collaborative, strategic flight planning. This opens up the possibility for inclusion of additional information in the collaborative decision-making process. With that in mind, we define the indicator for the economic risk of network elements (e.g., sectors or airports) as the expected costs that the elements impose on airspace users due to Air Traffic Flow Management (ATFM) regulations. The definition of the indicator is based on the analysis of historical ATFM regulations data, that provides an indication of the risk of accruing dela…
Analgēzijas nocicepsijas indekss - indikātors analgēzijai pleca artroskopiskās operācijās
2022
Pētījuma aktualitāte: Mūsdienās, akūtas sāpes bezsamaņā esošiem pacientiem objektivizēt ir sarežģīti. Analgēzijas Nocicepcijas Indekss (ANI) ir jauna metode, kas ir paredzēta akūtu sāpju diagnostikai, gadījumos, kad pacients nav pie samaņas. Mērķis: Noteikt ANI efektivitāti akūtu sāpju detekcijā vispārējās anestēzijas (VA) iespaidā esošiem pacientiem. Hipotēze: ANI ir noderīgs palīgrīks anesteziologiem savlaicīgai intraoperatīvai akūtu sāpju detekcijai un personalizētai pacienta atsāpināšanas terapijai. Darba uzdevumi: Novērtēt ANI rādītājus eksperimentālajā grupā (EG) un salīdzināt tos ar kontrolgrupas rādītājiem (KG). Izanalizēt vai EG ir novērojami zemāki ANI rādītāji. Pārbaudīt vai ir n…