Search results for "Organ transplant"
showing 7 items of 97 documents
Forty-One Recent Cases of Invasive Zygomycosis From a Global Clinical Registry.
2009
Abstract Abstract 4736 Background Invasive zygomycosis accounts for a significant proportion of all invasive fungal diseases (IFD), but clinical data on the clinical course and treatment response is limited. Methods Fungiscope” - A Global Rare Fungal Infection Registry is a university-based case registry that collects data of patients with rare IFD, using a web-based electronic case form at www.fungiscope.net. Results Fourty-one patients with invasive zygomycosis were registered. Five were pediatric (12.2%), 28 (68.3%) male. Median age was 49 years (range 2-88). Most common underlying conditions were malignancies (n=26; 63.4%), diabetes mellitus (n=7; 17%) and solid organ transplant (n=4; 9…
Rhino cerebral mucormycosis: a report of two cases and review of literature.
2011
Mucormycosis is caused by fungi of the order Mucorales and is one of the fulminant and fatal mycotic infections known to human beings with a high mortality rate. Rhinocerebral mucormycosis is the most common type and its extension to the orbit and brain is quite usual. It is commonly reported in immunocompromised patients such as poorly controlled diabetes mellitus, blood dyscrasias, malnutrition, neutropenia, iron overload, organ transplant, and immunosuppressive therapy. Mucormycosis is on the rise with an increase in incidence of Diabetes mellitus and HIV infection leading to immunocompromised status of the patient. Here in, reporting two cases of rhinocerebral mucormycosis in two uncont…
Role of Ischemia/Reperfusion Injury in Organ Transplantation
1997
Reperfusion of oxygenated blood into previously ischemic tissue is essential to prevent the progression of cellular injury due to the decreased nutritional blood flow, i.e., the decreased delivery of oxygen and metabolic substrates, as well as the removal of harmful metabolic byproducts. However, it has become obvious that reperfusion also initiates a complex series of pathologic events that contribute to, rather than prevent, further tissue damage. Moreover, a growing body of evidence indicates that ischemia/reperfusion injury is initiated by events that occur at the level of the microcirculation. In the first part of this overview, we will delineate the major components of the microcircul…
Leishmaniasis among organ transplant recipients.
2008
Leishmaniasis is a rarely reported disease among transplant recipients; however, the number of published cases has quadrupled since the beginning of the 1990s. Most cases have been observed in patients living in countries of the Mediterranean basin. Leishmaniasis is most commonly associated with kidney transplantation (77%), and cases are also recorded among patients undergoing liver, heart, lung, pancreas, and bone marrow transplantation. Visceral leishmaniasis (VL) is the most frequently observed clinical presentation, followed by mucosal leishmaniasis and more rarely cutaneous leishmaniasis. Transplant recipients with VL develop the classic clinical form of the disease, which is a febril…
Emergency abdominal surgery after solid organ transplantation: a systematic review
2016
Aims: Due to the increasing number of solid organs transplantations, emergency abdominal surgery in transplanted patients is becoming a relevant challenge for the general surgeon. The aim of this systematic review of the literature is to analyze morbidity and mortality of emergency abdominal surgery performed in transplanted patients for graft-unrelated surgical problems. Methods: The literature search was performed on online databases with the time limit 1990–2015. Studies describing all types of emergency abdominal surgery in solid organ transplanted patients were retrieved for evaluation. Results: Thirty-nine case series published between 1996 and 2015 met the inclusion criteria and were…
Role of Human Leukocyte Antigens (HLA) in Autoimmune Diseases
2018
Since the discovery of HLA 60 years ago, it has contributed to the understanding of the immune system as well as of the pathogenesis of several diseases. Aside from its essential role in determining donor-recipient immune compatibility in organ transplantation, HLA genotyping is meanwhile performed routinely as part of the diagnostic work-up of certain autoimmune diseases. Considering the ability of HLA to influence thymic selection as well as peripheral anergy of T cells, its role in the pathogenesis of autoimmunity is understandable. The aim of this paper is to provide a brief overview of the role and current clinical relevance of HLA-B27 in spondyloarthritis and HLA-B51 in Behçet's disea…
PRODUZIONE DI RIFIUTI A RISCHIO INFETTIVO E INDICI DI COMPLESSITÀ IN UN “CENTRO TRAPIANTI”
2015
Questo studio analizza la produzione di rifiuti a rischio infettivo in una grande struttura ospedaliera specializzata per le attività di trapianto: Ismett (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), che si trova a Palermo. Sono state determinate le relazioni fra la quantità e la composizione dei rifiuti, da una parte; la complessità della struttura e la natura delle cure erogate, dall’altra. In letteratura si trovano regolarmente i risultati di ricerche sulla produzione di rifiuti a rischio infettivo nei più diversi Paesi del mondo; i dati pubblicati provengono quasi esclusivamente da Ospedali Generali, anche complessi e di Alta Specializzazione. Tali dati po…