Search results for "Organisation"

Thorough evaluation of OECD principles in modelling of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives using QSARINS.

2020

The human immunodeficiency virus is a lethal pathology considered as a worldwide problem. The search for new strategies for the treatment of this disease continues to be a great challenge in the scientific community. In this study, a series of 107 derivatives of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine, previously evaluated experimentally against HIV-I reverse transcriptase, was used to model antiretroviral activity. A model of linear regression, implemented in the QSARINS software, was developed with a genetic algorithm for variable selection. The fit of its parameters was good and exhaustive validation, according to the OECD regulatory principles, was performed. Also, the applica…

Hierarchical networks of food exchange in the black garden ant Lasius niger

2020

In most eusocial insects, the division of labour results in relatively few individuals foraging for the entire colony. Thus, the survival of the colony depends on its efficiency in meeting the nutritional needs of all its members. Here, we characterise the network topology of a eusocial insect to understand the role and centrality of each caste in this network during the process of food dissemination. We constructed trophallaxis networks from 34 food-exchange experiments in black garden ants (Lasius niger). We tested the influence of brood and colony size on (i) global indices at the network level (i.e. efficiency, resilience, centralisation and modularity) and (ii) individual values (i.e. …

A niche perspective on the range expansion of symbionts.

2020

Range expansion results from complex eco-evolutionary processes where range dynamics and niche shifts interact in a novel physical space and/or environment, with scale playing a major role. Obligate symbionts (i.e. organisms permanently living on hosts) differ from free-living organisms in that they depend on strong biotic interactions with their hosts which alter their niche and spatial dynamics. A symbiotic lifestyle modifies organism–environment relationships across levels of organisation, from individuals to geographical ranges. These changes influence how symbionts experience colonisation and, by extension, range expansion. Here, we investigate the potential implications of a symbiotic…

Symmetry breaking in mass-recruiting ants: extent of foraging biases depends on resource quality.

2016

Abstract The communication involved in the foraging behaviour of social insects is integral to their success. Many ant species use trail pheromones to make decisions about where to forage. The strong positive feedback caused by the trail pheromone is thought to create a decision between two or more options. When the two options are of identical quality, this is known as symmetry breaking, and is important because it helps colonies to monopolise food sources in a competitive environment. Symmetry breaking is thought to increase with the quantity of pheromone deposited by ants, but empirical studies exploring the factors affecting symmetry breaking are limited. Here, we tested if (i) greater …

Herpes simplex virus 1 induces egress channels through marginalized host chromatin

2016

AbstractLytic infection with herpes simplex virus type 1 (HSV-1) induces profound modification of the cell nucleus including formation of a viral replication compartment and chromatin marginalization into the nuclear periphery. We used three-dimensional soft X-ray tomography, combined with cryogenic fluorescence, confocal and electron microscopy, to analyse the transformation of peripheral chromatin during HSV-1 infection. Our data showed an increased presence of low-density gaps in the marginalized chromatin at late infection. Advanced data analysis indicated the formation of virus-nucleocapsid-sized (or wider) channels extending through the compacted chromatin of the host. Importantly, co…

Training the translator trainers : an introduction

2019

This is an Accepted Manuscript of an article published by Taylor & Francis in [The Interpreter and Translator Trainer] on [09 Oct 2019], available online: http://www.tandfonline.com/10.1080/1750399X.2019.1647821

Group Analysis and the Self: The Political-Environmental-Transpersonal

1996

In this paper the authors try to put the basis for a new sense of group analysis, meant as the psychology of the field and the future, able to unblock saturated sets of meanings. Their work with groups has shown that there is a time in the group analytic process in which the individual explores the possibility of changeover. That time is also the space for the foundation of a new Self: the space for the difference, the space for the fight for giving and receiving'.

The WHO-5 Well-Being Index – Validation based on item response theory and the analysis of measurement invariance across 35 countries.

2020

Abstract Background The five-item World Health Organization Well-Being Index (WHO-5) is a frequently used brief standard measure in large-scale cross-cultural clinical studies. Despite its frequent use, some psychometric questions remain that concern the choice of an adequate item response theory (IRT) model, the evaluation of reliability at important cutoff points, and most importantly the assessment of measurement invariance across countries. Methods Data from the 6th European Working Condition survey (2015) were used that collected nationally representative samples of employed and self-employed individuals (N = 43,469) via computer-aided personal interviews across 35 European countries. …

Latvijas Vēstures Institūta Žurnāls. 2012, Nr. 3 (84)

2012

Лифляндская губернская подготовительная комиссія, 1906 г. [Лифляндская губернская подготовительная комиссия, 1906 г.]

1906

Содержание: Журналы заседаний Лифляндской губернской подготовительной комиссии (№ 1-13) по делам земского самоуправления, по учебной части, по делам церковного управления, по аграрным вопросам, о реорганизации волостного самоуправления, по судебной части. Список членов Лифл. губернской подготовительной комиссии. Перечен вопросов, внесенных на обсуждение Лифл. подготовительной комисси и другие материалы.