Search results for "Organo"

Comparative biological evaluation and G-quadruplex interaction studies of two new families of organometallic gold(I) complexes featuring N-heterocycl…

2020

Experimental organometallic gold(I) compounds hold promise for anticancer therapy. This study reports the synthesis of two novel families of gold(I) complexes, including N1-substituted bis-N-heterocyclic carbene (NHC) complexes of general formula [Au(N1-TBM) 2]BF 4 (N1-TBM = N1-substituted 9-methyltheobromin-8-ylidene) and mixed gold(I) NHC-alkynyl complexes, [Au(N1-TBM)alkynyl]. The compounds were fully characterised for their structure and stability in aqueous environment and in the presence of N-acetyl cysteine by nuclear magnetic resonance (NMR) spectroscopy. The structures of bis(1-ethyl-3,7,9-trimethylxanthin-8-ylidene)gold(I), (4-ethynylpyridine)(1,9-dimethyltheobromine-8-ylidene)gol…

Thiourea Organocatalysts as Emerging Chiral Pollutants: En Route to Porphyrin-Based (Chir)Optical Sensing

2021

Environmental pollution with chiral organic compounds is an emerging problem requiring innovative sensing methods. Amino-functionalized thioureas, such as 2-(dimethylamino)cyclohexyl-(3,5-bis(trifluoromethyl)phenyl)thiourea (Takemoto’s catalyst), are widely used organocatalysts with virtually unknown environmental safety data. Ecotoxicity studies based on the Vibrio fischeri luminescence inhibition test reveal significant toxicity of Takemoto’s catalyst (EC50 = 7.9 mg/L) and its NH2-substituted analog (EC50 = 7.2–7.4 mg/L). The observed toxic effect was pronounced by the influence of the trifluoromethyl moiety. En route to the porphyrin-based chemosensing of Takemoto-type thioureas, their s…

The metabolic profile of lemon juice by proton HR-MAS NMR: the case of the PGI Interdonato Lemon of Messina

2015

We have studied by means of High Resolution Magic Angle Spinning Nuclear Magnetic Resonance (HR-MAS NMR) the metabolic profile of the famous Sicilian lemon known as 'Interdonato Lemon of Messina PGI'. The PGI Interdonato Lemon of Messina possesses high organoleptic and healthy properties and is recognised as one of the most nutrient fruits. In particular, some of its constituents are actively studied for their chemo-preventive and therapeutic properties. In this paper, we have determined by means of HR-MAS NMR spectroscopy the molar concentration of the main metabolites constituent the juice of PGI Interdonato Lemon of Messina in comparison with that of the not-PGI Interdonato Lemon of Turk…

Interdonato lemon from Nizza di Sicilia (Italy): chemical composition of hexane extract of lemon peel and histochemical investigation

2015

Considering that the determination of authenticity and of the geographical origin of food is a very challenging issue, in this study we studied by means of histological and histochemical analyses the famous Sicilian lemon known as ‘Interdonato Lemon of Messina PGI’. Since the protected geographical indication Interdonato lemon of Messina possesses high organoleptic properties, the composition of the hexane extract of lemon peel was determined by HRGC and HRGC–MS analyses and compared with that of lemon of different cultivars. The results obtained are informative of the oil’s quality and explain the variation of the lemon essential oil composition. Given the fundamental economic implications…

“AD HOC” MODIFIED CLAYS FOR BIOTECHNOLOGICAL APPLICATIONS

Nowadays, the scientific community has to face with cogent problems strictly linked to the improvement of quality of live. Among the different tasks to achieve the prefixed objective the focus has been put on the drug administration, i.e., attention has been paid to propose an appropriate solution to improve the performance of a drug delivery system and to eliminate both the side effect and drawbacks. With the aim to achieve the design, synthesis, and characterization of versatile systems, with peculiar characteristics, based on clays and clays modified with a biocompatible surfactant, able to adsorb and release organic substances of pharmaceutical interest the present PhD thesis has been u…

Permeability and toxicological profile estimation of organochlorine compounds by biopartitioning micellar chromatography

2008

This paper points out the usefulness of biopartitioning micellar chromatography (BMC) as a high-throughput primary screening tool providing key information about the oral absorption, skin permeability (Kp), brain–blood distribution coefficient (BB) and ecotoxicological parameters such as median lethal concentration (LC50) and bioconcentration factors of 15 organochloride compounds. The retention data of compounds in BMC conditions were interpolated in previously developed quantitative–retention activity relationships by our research group. Results show that the compounds studied readily cross the intestinal barrier (oral absorption >ercnt;) and the blood–brain barrier (log BB >p;0.4). In ad…

Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate

2021

International audience; Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi9O7} and {Bi38O44}, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi3+ displacements. This explains why such “magic-size” clusters can be both stab…

Informed Play: Approaching a Concept and Biology of Tone Production on Early Modern Lute Instruments

2018

Informed Play presents a conceptual understanding of tone production based on extensive historical research on primary sources, modern literature and handbook reviews, physical and psychological perspectives as well as on technology. As the first volume in English to discuss and contextualise the topic of tone production on Early Modern lute instruments from a broad, interdisciplinary approach, it represents a unique and significant contribution to research on Early Music performance, particularly performance on lute instruments. At a lute-centred level, this book challenges many preconceptions about tone production by addressing the motivations behind certain choices made in and embraced b…

Efficacy and safety of cyclic pyranopterin monophosphate substitution in severe molybdenum cofactor deficiency type A: a prospective cohort study.

2015

Summary Background Molybdenum cofactor deficiency (MoCD) is characterised by early, rapidly progressive postnatal encephalopathy and intractable seizures, leading to severe disability and early death. Previous treatment attempts have been unsuccessful. After a pioneering single treatment we now report the outcome of the complete first cohort of patients receiving substitution treatment with cyclic pyranopterin monophosphate (cPMP), a biosynthetic precursor of the cofactor. Methods In this observational prospective cohort study, newborn babies with clinical and biochemical evidence of MoCD were admitted to a compassionate-use programme at the request of their treating physicians. Intravenous…

Complessi di Organostagno(IV) con amminoacidi e dipeptidi: sintesi, caratterizzazione e attività biologica in vitro.

2008

Scopo della ricerca è la sintesi, caratterizzazione strutturale ed attività biologica di complessi di organostagno(IV) e amminoacidi quali L-arginina (Arg), N-Boc-L-arginina (Boc-Arg), L-ornitina (L-Orn) ed un dipeptide contenente L-arginina, Alanil-Arginina (Ala-Arg). I complessi di diorganostagno(IV) sono noti possedere attività antitumorale [1], antimicrobica [2] e antiinfiammatoria. I complessi di triorganostagno(IV) inibiscono la funzione mitocondriale almeno in tre modi: 1) reagendo con le membrane cellulari; 2) alterando lo scambio Cl-/OH- attraverso la membrana; 3) inibendo la fosforilazione ossidativa o l’idrolisi di ATP [3].L’arginina (Arg) è un amminoacido essenziale con un grup…