6533b859fe1ef96bd12b79e5
RESEARCH PRODUCT
Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate
O. IvashkoDavin TanHatem M. TitiAnn-christin DippelNicolas GeoffroyOlof GutowskiYoann RousselinPetra Spoerk-erdelyPhilipp GlaeveckeDaniel SzczerbaVasilii V. BazhenovJessica M. HudspethDenis ChaumontTomislav FriščićM.c. Marco De LucasMichel MeyerIvan HalaszValérie SchwanenSiham MouhtadiJean-louis DoSimon A. J. KimberMihails Arhangelskissubject
Cluster chemistrychemistry.chemical_element[CHIM.THER]Chemical Sciences/Medicinal Chemistry010402 general chemistry01 natural sciencesBiochemistryCatalysisBismuth subsalicylateBismuthlaw.inventionColloidColloid and Surface ChemistrylawCluster (physics)medicineOrganometallic Compounds[CHIM.COOR]Chemical Sciences/Coordination chemistryCrystallization010405 organic chemistryPair distribution functionGeneral ChemistrySalicylates0104 chemical sciences[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistryCrystallographychemistrySolvolysisCrystallization ; Group theory ; Bismuth ; Cluster chemistry ; Metal clustersBismuthmedicine.drugdescription
International audience; Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi9O7} and {Bi38O44}, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi3+ displacements. This explains why such “magic-size” clusters can be both stable enough to crystallize and sufficiently labile for further growth.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-01-01 |