Search results for "Ostas"
showing 10 items of 874 documents
Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems.
2015
Microglia are brain macrophages that emerge from early erythro-myeloid precursors in the embryonic yolk sac and migrate to the brain mesenchyme before the blood brain barrier is formed. They seed the brain, and proliferate until they have formed a grid-like distribution in the central nervous system that is maintained throughout lifespan. The mechanisms through which these embryonic-derived cells contribute to microglia homoeostasis at steady state and upon inflammation are still not entirely clear. Here we review recent studies that provided insight into the contribution of embryonically-derived microglia and of adult 'microglia-like' cells derived from monocytes during inflammation. We ex…
Fenotipo celular de las neuronas sensitivas afectadas en la ataxia de Friedreich
2016
Tesis Doctoral, 223 páginas, 64 figuras, 13 tablas.
Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Nav) channels properties
2021
The precise mechanisms underlying the detrimental effects of early life adversity (ELA) on adult mental health remain still elusive. To date, most studies have exclusively targeted neuronal populations and not considered neuron-glia crosstalk as a crucially important element for the integrity of stress-related brain function. Here, we have investigated the impact of ELA, in the form of a limited bedding and nesting material (LBN) paradigm, on a glial subpopulation with unique properties in brain homeostasis, the NG2+ cells. First, we have established a link between maternal behavior, activation of the offspring's stress response and heterogeneity in the outcome to LBN manipulation. We furth…
Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling
2013
Polymorphonuclear neutrophil granulocytes (neutrophils) are tightly controlled by an incompletely understood homeostatic feedback loop adjusting the marrow's supply to peripheral needs. Although it has long been known that marrow cellularity is inversely correlated with G-CSF levels, the mechanism linking peripheral clearance to production remains unknown. Herein, the feedback response to antibody induced neutropenia is characterized to consist of G-CSF–dependent shifts of marrow hematopoietic progenitor populations including expansion of the lin-/Sca-1/c-kit (LSK) and granulocyte macrophage progenitor (GMP) compartments at the expense of thrombopoietic and red cell precursors. Evidence is …
Inflammation and Cancer of the Prostate
2012
In response to cell injury elicited by trauma or infection, the inflammatory response creates a complex network of molecular and cellular interactions leading to the facilitation of tissue repair and to return to a physiological homeostatic condition. In case the healthy tissue is not restored, or in response to a stable low-grade irritation, inflammation becomes a chronic condition that incessantly damages the surrounding tissue and whereby immune response, tissue injury, and healing processes occur simultaneously [1].
Les actes del mustassaf de Sueca (1571-1578)
1990
L’absència generalitzada de documentació relativa a l’actuació processal diària del mostassaf, oficial de l’organització municipal valenciana, s’explica pel caràcter sumari de les seues decisions i la circumscripció a l’àmbit de l’oralitat, prescrita explícitament per la legislació foral. Tanmateix i de forma excepcional, d’un període breu, els anys 1571 a 1578, i en un lloc rural, Sueca, aquest oficial deixà constància escrita de la seua actuació, cosa que ens permet reconstruir l’estructura del procediment judicial seguit pel mostassaf i la tipologia de les causes dirimides, així com de les penes imposades.
OCTN2-Mediated Carnitine Uptake in a Newly Discovered Human Proximal Tubule Cell Line (Caki-1)
2006
The proximal tubular reabsorption of carnitine in the human kidney is significant because more than 95% of the carnitine filtered in the kidney is reabsorbed by the proximal tubules therefore maintaining the homeostatic balance of carnitine in the body. Objectives of this study include the characterization of OCTN2 function in the Caki-1 cell line and the potential interactions of carnitine uptake with renally secreted drugs, including drugs of quaternary ammonium structure. Caki-1 cells were additionally characterized to be of proximal tubule nature, and an apical membrane expression pattern of OCTN2 in Caki-1 cells was discovered. Uptake studies with radiolabeled L-carnitine in Caki-1 cel…
Приморскіе торговые порты Европейской Россіи: Бѣлое, Балтійское, Черное и Азовское моря [Приморские торговые порты Европейской России...]
1908
Содержание: 1) Введение. I. Очеркъ развитія приморскихъ торговыхъ портовъ Европейской Россіи ; II. Строительные и эксплоатаціонные расходы въ портахъ ; III. Мѣстныя Управленія приморскими торговыми портами ; 2) БѢЛОЕ МОРЕ. I. Описаніе моря, побережья и второстепенныхъ портовъ ; II. Архангельский портъ ; 3) БАЛТІЙСКОЕ МОРЕ. I. Описаніе моря, побережья и второстепенныхъ портовъ ; II. С.-Петербургскій портъ ; III. Ревельскій портъ ; IV. Рижскій портъ ; V. Виндавскій портъ ; VI. Либавскій портъ ; 4) ЧЕРНОЕ МОРЕ. I. Описаніе моря, побережья и второстепенныхъ портовъ ; II. Одесскій портъ ; III. Днѣпровско-Бугскій лиманъ, Николаевскій и Херсонскій порты ; IV. Ялтинскій портъ ; V. Ѳеодосійскій порт…
Biological Causes of Anterior Knee Pain
2012
We review the pathophysiology of anterior knee pain in the young patient. Emphasis is placed on newer findings. We have developed what we call the “Neural Model” as an explanation for the genesis of anterior knee pain. We have demonstrated a neuroanatomical basis for PFPS in the young patient and the clinical observation that the lateral retinaculum may have a key role in the origin of this pain. According to our studies we hypothesize that periodic short episodes of ischemia in the lateral retinaculum could be implicated in the pathogenesis of anterior knee pain, at least in a subgroup of anterior knee pain patients, by triggering neural proliferation of nociceptive axons (substance P posi…
The Wnt/beta-Catenin Pathway Attenuates Experimental Allergic Airway Disease
2014
Abstract Signaling via the Wnt/β-catenin pathway plays crucial roles in embryogenesis and homeostasis of adult tissues. In the lung, the canonical Wnt/β-catenin pathway has been implicated in remodeling processes, development of emphysema, and fibrosis. However, its relevance for the modulation of allergic responses in the lung remains unclear. Using genetically modified mice with lung-specific inducible (doxycycline) Wnt-1 expression (CCSP-rtTA × tetO-Wnt1), the impact of Wnt on the development of allergic airway disease was analyzed. Overexpression of Wnt during the allergen challenge phase attenuated the development of airway inflammation in an acute model, as well as in a more therapeut…