Search results for "Ostas"
showing 10 items of 874 documents
Effect of Non-Surgical Periodontal Treatment on Oxidative Stress Markers in Leukocytes and Their Interaction with the Endothelium in Obese Subjects w…
2020
Aim: The primary objective of this pilot study was to evaluate the effect of non-surgical periodontal treatment. The secondary aim was to evaluate the effect of dietary therapy on both parameters of oxidative stress in leukocytes and leukocyte-endothelial cell interactions in an obese population. Methods: This was a pilot study with a before-and-after design. Forty-nine obese subjects with periodontitis were randomized by means of the minimization method and assigned to one of two groups, one of which underwent dietary therapy while the other did not. All the subjects underwent non-surgical periodontal treatment. We determined periodontal, inflammatory and oxidative stress parameters&mdash
The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms.
2015
Objectives:\ud The corticotrophin-releasing factor (CRF)/urocortin system is expressed in the adipose tissue of mammals, but its functional role in this tissue remains unknown.\ud \ud Methods:\ud Pharmacological manipulation of the activity of CRF receptors, CRF1 and CRF2, was performed in 3T3L1 white pre-adipocytes and T37i brown pre-adipocytes during in vitro differentiation. The expression of genes of the CRF/urocortin system and of markers of white and brown adipocytes was evaluated along with mitochondrial biogenesis and cellular oxygen consumption. Metabolic evaluation of corticosterone-deficient or supplemented Crhr1-null (Crhr1−/−) mice and their wild-type controls was performed alo…
High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice
2021
In the large GWAS studies, NEGR1 gene has been one of the most significant gene loci for body mass phenotype. The purpose of the current study was to clarify the role of NEGR1 in the maintenance of systemic metabolism, including glucose homeostasis, by using both male and female Negr1−/− mice receiving a standard or high fat diet (HFD). We found that 6 weeks of HFD leads to higher levels of blood glucose in Negr1−/− mice. In the glucose tolerance test, HFD induced phenotype difference only in male mice
Fighting the Consequences of the COVID-19 Pandemic: Mindfulness, Exercise, and Nutrition Practices to Reduce Eating Disorders and Promote Sustainabil…
2023
Over the past two years, the world’s population has been tested by the COVID-19 health emergency. This has changed population habits worldwide by encouraging a sedentary lifestyle and overnutrition. Isolation and reduction of social life, for most of the population, was mandatory but it quickly became a new lifestyle. Nowadays, we are encountering the consequences with an increase in nutritional associated disorders and conditions that cause illnesses in the general population. These disorders include diet excesses that lead to obesity and diet deficiencies and malnutrition which could rapidly lead to death. These eating disorders are very complex to manage because they become mental disord…
Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging
2013
Recent genome-wide association studies have linked type-2 diabetes mellitus to a genomic region in chromosome 9p21 near the Ink4/Arf locus, which encodes tumor suppressors that are up-regulated in a variety of mammalian organs during aging. However, it is unclear whether the susceptibility to type-2 diabetes is associated with altered expression of the Ink4/Arf locus. In the present study, we investigated the role of Ink4/Arf in age-dependent alterations of insulin and glucose homeostasis using Super-Ink4/Arf mice which bear an extra copy of the entire Ink4/Arf locus. We find that, in contrast to age-matched wild-type controls, Super-Ink4/Arf mice do not develop glucose intolerance with agi…
Jūras un sauszemes funkcionālā sasaiste: Rīgas brīvostas plānošanas piemērs
2015
Ekonomisko aktivitāšu un to negatīvās ietekmes pieaugums uz dabas vērtībām jūrā un citiem jūras telpas un piekrastes teritorijas izmantošanas veidiem veicina konfliktsituāciju rašanos Baltijas jūras teritorijā. Lai novērstu jūras un sauszemes teritoriju izmantošanas veidu sadursmi, ir būtiski koordinēt un saskaņot gan jūras, gan ostas, kā arī ostas - pilsētas plānošanas telpu prioritātes un attīstības mērķus. Maģistra darba mērķis ir izstrādāt plānošanas priekšlikumus sauszemes un jūras funkcionālo konfliktu risinājumiem Rīgas brīvostā un tai piegulošajā teritorijā. Maģistra darbā tika noteikti galvenie saimnieciskie darbības virzieni Rīgas brīvostā un tai piegulošā teritorijā, kā arī veikt…
Dental treatment of patients with coagulation factor alterations: An update
2007
Hemostasia is a defense mechanism that protects vascular integrity, avoids blood loss, and maintains blood fluidity throughout the circulatory system. The biochemical processes leading to blood clot formation are complex, and alterations can appear at any point within the chain of events. While a range of alterations can affect the coagulation factors, some are more common than others in the general population, including congenital (hemophilia A and B, Von Willebrand’s disease) and acquired disorders (anticoagulant drugs). Such diseases require special consideration in the context of dental treatment, and therefore must be known to dental professionals. Interconsultation with the hematologi…
Publiskas personas pārveide par kapitālsabiedrību: ostu piemērs
2021
Maģistra darbs “Publiskas personas pārveide par kapitālsabiedrību: ostu piemērs” ir uzrakstīts Latvijas Universitātes Juridiskās fakultātes Valststiesību zinātņu katedrā. Autors darbā ir izpētījis normatīvos aktus un tiesu praksi publiskas personas tiesībām veikt komercdarbību, t.s, caur līdzdalību kapitālsabiedrībās. Apskatīti Latvijas ostu darbības principi, pārvaldības kārtība, analizētas ostu funkcijas privāto un publisko tiesību jomā, kā arī apskatīta ārvalstu prakse ostu pārvaldībā. Darba noslēgumā autors izpētījis pārvaldības juridiskās formas maiņu Ventspils ostā, norādot uz problēmām un ieguvumiem. Noslēgumā secināts, ka ostu komercializācija ir starptautiski izplatīta prakse, kas …
Computation of the lock-in ranges of phase-locked loops with PI filter
2016
In the present work the lock-in range of PLL-based circuits with proportionallyintegrating filter and sinusoidal phase-detector characteristics are studied. Considered circuits have sinusoidal phase detector characteristics. Analytical approach based on the methods of phase plane analysis is applied to estimate the lock-in ranges of the circuits under consideration. Obtained analytical results are compared with simulation results. peerReviewed
Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 ph…
2006
Aplidin® is an antitumor agent in phase II clinical trials that induces apoptosis through the sustained activation of Jun N-terminal kinase (JNK). We report that Aplidin® alters glutathione homeostasis increasing the ratio of oxidized to reduced forms (GSSG/GSH). Aplidin® generates reactive oxygen species and disrupts the mitochondrial membrane potential. Exogenous GSH inhibits these effects and also JNK activation and cell death. We found two mechanisms by which Aplidin® activates JNK: rapid activation of Rac1 small GTPase and downregulation of MKP-1 phosphatase. Rac1 activation was diminished by GSH and enhanced by L-buthionine (SR)-sulfoximine, which inhibits GSH synthesis. Downregulatio…