Search results for "Oxacyclododecindione"

showing 3 items of 3 documents

Total synthesis of two potent anti-inflammatory macrolactones of the oxacyclododecindione type

2015

An esterification/Friedel-Crafts-cyclization approach permitted the first successful synthetic entry into the oxacyclododecindione subclass of the dihydroxyphenylacetic acid lactone-type natural products. This route allowed the preparation of two highly active anti-inflammatory fungal secondary metabolites 14-deoxyoxacyclododecindione and 14-deoxy-4-dechlorooxacyclododecindione as well as their 14-desmethyl analogues.

Macrocyclic CompoundsMolecular StructureChemistrymedicine.drug_classDihydroxyphenylacetic acidStereochemistryAnti-Inflammatory Agents Non-SteroidalOrganic ChemistryTotal synthesisBiochemistrySubclassAnti-inflammatoryLactonesBiochemistryCyclizationmedicineOxacyclododecindionePhysical and Theoretical ChemistryOrganic & Biomolecular Chemistry
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ChemInform Abstract: Synthetic Approaches to Antiinflammatory Macrolactones of the Oxacyclododecindione Type.

2015

A variety of attempts to synthesize oxacyclododecindione macrolactones through carbonylative ring-closure, intramolecular alkyne hydroacyalation, and Ru-catalyzed double bond isomerization fails.

chemistry.chemical_classificationDouble bondchemistryStereochemistryIntramolecular forceSalt metathesis reactionOxacyclododecindioneAlkyneGeneral MedicineIsomerizationChemInform
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Correction: Total synthesis of two potent anti-inflammatory macrolactones of the oxacyclododecindione type

2015

Correction for ‘Total synthesis of two potent anti-inflammatory macrolactones of the oxacyclododecindione type’ by Johannes Tauber et al., Org. Biomol. Chem., 2015, 13, 7813–7821.

medicine.drug_classStereochemistryChemistryOrganic ChemistrymedicineOxacyclododecindioneTotal synthesisOrganic chemistryPhysical and Theoretical ChemistryBiochemistryAnti-inflammatoryOrganic & Biomolecular Chemistry
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