Search results for "Oxamide"

showing 10 items of 227 documents

CCDC 885911: Experimental Crystal Structure Determination

2013

Related Article: A.Suhonen, E.Nauha, K.Salorinne, K.Helttunen, M.Nissinen|2012|CrystEngComm|14|7398|doi:10.1039/c2ce25981h

N2N6-bis(2-benzamidophenyl)pyridine-26-dicarboxamide dimethylsulfoxide solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1555251: Experimental Crystal Structure Determination

2017

Related Article: Riia Annala, Aku Suhonen, Heikki Laakkonen, Perttu Permi, Maija Nissinen|2017|Chem.-Eur.J.|23|16671|doi:10.1002/chem.201703985

N2-{2-[(benzenecarbonyl)amino]phenyl}-N6-{2-[(2-{[6-({2-[(benzenecarbonyl)amino]phenyl}carbamoyl)pyridine-2-carbonyl]amino}benzene-1-carbonyl)amino]phenyl}pyridine-26-dicarboxamide ethyl acetate solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1555250: Experimental Crystal Structure Determination

2017

Related Article: Riia Annala, Aku Suhonen, Heikki Laakkonen, Perttu Permi, Maija Nissinen|2017|Chem.-Eur.J.|23|16671|doi:10.1002/chem.201703985

N2-{2-[(benzenecarbonyl)amino]phenyl}-N6-{2-[(2-{[6-({2-[(benzenecarbonyl)amino]phenyl}carbamoyl)pyridine-2-carbonyl]amino}benzene-1-carbonyl)amino]phenyl}pyridine-26-dicarboxamide perdeuterodimethyl sulfoxide solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1555257: Experimental Crystal Structure Determination

2017

Related Article: Riia Annala, Aku Suhonen, Heikki Laakkonen, Perttu Permi, Maija Nissinen|2017|Chem.-Eur.J.|23|16671|doi:10.1002/chem.201703985

N6N6'-[pyridine-26-diylbis(carbonylazanediyl-21-phenylene)]bis(N2-{2-[(benzenecarbonyl)amino]phenyl}pyridine-26-dicarboxamide) acetone solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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[2+2+2] Cycloadditions of Alkynylynamides - A Total Synthesis of Perlolyrine and the First Total Synthesis of “Isoperlolyrine”

2011

The total syntheses of the carboline alkaloids perlolyrine and "isoperlolyrine" are reported. Key-steps of the syntheses are Negishi coupling reactions on alkynylynamides and their metal-catalyzed [2+2+2] cycloadditions with nitriles to form the β- and γ-carboline cores. The choice of the catalyst strongly affects the β/γ ratio. Spectroscopic features of the γ-isomer are distinctly different from those of the naturally occurring isoperlolyrine.

NitrileChemistryNegishi couplingmedicine.drug_classStereochemistryOrganic ChemistryTotal synthesischemistry.chemical_elementCarboxamideChemical synthesisCycloadditionRhodiumCatalysischemistry.chemical_compoundmedicinePhysical and Theoretical ChemistryEuropean Journal of Organic Chemistry
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Synthesis and antifungal activity of new N-isoxazolyl-2-iodobenzamides

1999

N-Isoxazolyl-2-iodobenzamides 3 and 9, with a benodanil-like structure, were synthesized by refluxing in acetic acid the corresponding benzotriazinones 2 and 8 with potassium iodide for 1 h with the aim to ascertain if they were active as fungicides against Phytophthora citricola Saw., Botrytis cinerea Pers., Rhizoctonia sp. and Alternaria sp. Among the tested iodo derivatives, compounds 3b and 9a possess interesting activities against the aforesaid fungal strains in several cases similar to that of benodanil I taken as reference drug.

Phytophthora citricolaMagnetic Resonance SpectroscopyChemical PhenomenaSpectrophotometry Infraredmedicine.drug_classStereochemistryColony Count MicrobialPharmaceutical ScienceCarboxamideRhizoctoniaChemical synthesisAcetic acidchemistry.chemical_compoundN-Isoxazolyl-2-iodobenzamideDrug DiscoverymedicineAntifungal activityBotrytis cinereabiologyChemistry PhysicalfungiFungifood and beveragesIsoxazolesbiology.organism_classificationAlternariaSettore CHIM/08 - Chimica FarmaceuticaFungicides IndustrialFungicidechemistryBenzamides
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Synthesis, antiproliferative activity, and mechanism of action of a series of 2-{[2E]-3-phenylprop-2-enoylamino}benzamides

2011

Several new 2-{[(2E)-3-phenylprop-2-enoyl]amino}benzamides 12a–s and 17t–v were synthesized by stirring in pyridine the (E)-3-(2-R1-3-R2-4-R3-phenyl)acrylic acid chlorides 11c–k and 11t–v with the appropriate anthranilamide derivatives 10a–c or the 5-iodoanthranilic acid 13. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against the full NCI tumor cell line panel derived from nine clinically isolated cancer types (leukemia, non-small cell lung, colon, CNS, melanoma, ovarian, renal, prostate and breast). COMPARE analysis, effects on tubulin polymerization in cells and with purified tubulin, and effects on cell cycle distribution for 17t, the mo…

Pyridinesmedicine.drug_classStereochemistryAntineoplastic AgentsCarboxamideChemical synthesisArticlePolymerizationInhibitory Concentration 50Structure-Activity RelationshipTubulinCell Line TumorDrug DiscoverymedicineHumansStructure–activity relationshiportho-AminobenzoatesCytotoxicity2-{[2E]-3-phenylprop-2-enoylamino}benzamides antimitotic agents cytotoxic activityPharmacologyDose-Response Relationship DrugbiologyChemistryTubulin ModulatorsCell CycleOrganic ChemistryGeneral MedicineCell cycleSettore CHIM/08 - Chimica FarmaceuticaTubulin ModulatorsTubulinAcrylatesMechanism of actionBiochemistryBenzamidesbiology.proteinDrug Screening Assays Antitumormedicine.symptom
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Fluoreszierende silane als OH-selektive schutzgruppen

1985

Abstract Fluorescent tertiary silanes are synthesized which, under cesium fluoride/ imidazole activation, discriminate between primary and secondary OH groups. Serine n-butylamide reacts with [5-dimethylamino(1-naphthyl)]dimethylsilane ( 1 ) and diisopropyl[5-dimethylamino(1-naphthyl)]silane ( 2 ) to form the silyl ethers (−)- l -3-[5-dimethylamino(1-naphthyl)]-dimethylsilyloxy]serine n-butylamid ( 14 ) and (−)- l -3-[diisopropyl[5-dimethylamino(1-naphthyl)]silyloxy]serine n-butylamid ( 15 ) exclusively. The silyl ethers are cleaved on treatment with H 2 F 2 , forming the corresponding fluorescent silyl fluorides. Absorption and fluorescence data as well as stability data for the hydrolysis…

SilanesDimethylsilaneSilylationChemistrymedicine.drug_classStereochemistryOrganic ChemistryCarboxamideBiochemistryMedicinal chemistryInorganic Chemistrychemistry.chemical_compoundpolycyclic compoundsMaterials ChemistrymedicineImidazolePhysical and Theoretical ChemistryProtecting groupAliphatic compoundFluorideJournal of Organometallic Chemistry
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CCDC 245908: Experimental Crystal Structure Determination

2006

Related Article: R.Frohlich, T.C.Rosen, O.G.J.Meyer, K.Rissanen, G.Haufe|2006|J.Mol.Struct.|787|50|doi:10.1016/j.molstruc.2005.10.033

Space GroupCrystallography(1R2S)-(-)-2-Fluoro-2-phenylcyclopropanecarboxamideCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1521297: Experimental Crystal Structure Determination

2017

Related Article: Marlena Łukomska-Rogala, Agnieszka J. Rybarczyk-Pirek, Krzysztof Ejsmont, Marcin Jasiński, Marcin Palusiak|2017|Struct.Chem.|28|1229|doi:10.1007/s11224-017-0935-x

Space GroupCrystallography15-dimethyl-3-oxo-N-(4-(trifluoromethyl)phenyl)-1H-imidazole-4-carboxamideCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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