Search results for "Oxytocin"

CNS depressant effects, anti-inflammatory activity and anti-cholinergic actions ofSantolina chamaecyparissus extracts

1988

The pharmacological activity of several extracts together with the lyophilized infusion of S. chamaecyparissus ssp. squarrosa were investigated. The lethal dose 50% (LD50), effect on animal metabolism, mechanical and thermic analgesia and spontaneous, anti-inflammatory, and anti-ulcer activity have been determined. Studies on isolated organs (rat duodenum and rat uterus) were also carried out. The hexanic and chloroformic extracts were potent antagonists of the thermic analgesia test; the former extract was also active in the mechanical analgesia test. The chloroformic extract and, to a lesser extent, the ethyl acetate extract and lyophilized infusion demonstrated noteworthy activity as ant…

Inhibition of uterine contractility by guanine-based purines in non-pregnant rats

2022

Growing evidence pointed out that guanine-based purines are able to modulate smooth muscle contractile activity of blood vessels and gastrointestinal tract. Since, so far, possible guanine-based purine modulation of uterine musculature is unknown, the aim of the present study was to investigate in vitro, using organ bath technique, guanosine and guanine efects on spontaneous uterine contraction, and uterine contraction induced by K+-depolarization and oxytocin in a non-pregnant rat. Guanosine, but not guanine, reduced the amplitude of spontaneous contraction of the uterine muscle in a dose-dependent manner. The inhibitory response was antagonized by S-(4-nitrobenzyl)-6-thioinosine (NBTI), a…

Die diuretische Wirkung von Oxytocin beim Hund

1959

The influence of a synthetic oxytocin preparation and of prednisolone hemisuccinate on the renal excretions of water, sodium, potassium and chloride and on the clearance of endogenous true creatinine was studied in 18 dogs anesthetized with hexobarbital and barbital. The animals were deprived of food and water for 12 hours before the experiments.

Der Einflu� von Oxytocin auf die renale Wasser- und Salzausscheidung der Ratte

1956

Es wird zunaichst uber die Steigerung des Glutaminsaure/Glutamingehaltes einzelner Organe nach Futterung hoher Dosen Glutaminsaure berichtet, weiterhin die Frage zu klaren versucht, ob die nach Futterung hoher Glutaminsauredosen auftretende Bradykardie zentralen Ursprungs ist. Schlieβlich wird a u f die Beeinfluβung des Glutaminsaiurestoffwechsels durch Folsaure eingegangen, d i e als Storung der Acetyleholinbildung gedeutet wird.

Der Einflu� von nat�rlichem und synthetischem Oxytocin auf endogene Kreatinin-Clearance, Salzausscheidung und S�ureausscheidungsf�higkeit der Ratte u…

1957

Oxytocin receptor ligands: a survey of the patent literature

2008

Background: Oxytocin is produced primarily in hypothalamic neurons and is secreted from the posterior pituitary gland into the circulation in response to stimuli such as suckling, parturition, or stress. Oxytocin functions as an essential component in milk ejection and is among the most potent uterotonic substances known. The oxytocin receptor system supports physiological processes associated with reproduction at several levels. Objective: To characterize and evaluate oxytocin receptor ligands for therapeutic applications. Methods: Analysis of oxytocin analogs and nonpeptide oxytocin receptor ligands, and major applications of these substances. Results/conclusion: Oxytocin receptor ligands…

Die Konzentration von Noradrenalin und Adrenalin in den einzelnen Abschnitten des Herzens

1959

1. A method for the assay of noradrenaline and adrenaline in small pieces of heart tissue is described. The amines were extracted with acid ethanol and separated by paper chromatography. The regions containing the amines were eluted and the amount of amines in the eluates was determined by bioassay. Noradrenaline was assayed on the blood pressure of the pithed rat. Adrenaline was assayed on the isolated atropinized rat's uterus stimulated with oxytocin. 2. The identity of the substances tested by bioassay with noradrenaline and adrenaline was confirmed by a number of chemical and pharmacological tests. 3. The concentration of catechol amines in different parts of the heart was studied in ca…

Nebennieren undrenale Oxytocin-Wirkungen bei der Ratte

1959

No significant improvement in water diuresis was obtained by the s. c. injection of 500–1000 mU/kg of a synthetic oxytocin preparation (Syntocinon) in adrenalectomized, salt-maintained rats given 18 ml of water per rat by stomach tube. In these animals oxytocin had, on the other hand, a strong natriuretic and chloruretic effect.

Zur Wirkung von Oxytocin auf einen autorhythmischen glatten Gefässmuskel

1972

The influence of oxytocine on the spontaneously contractile portal vein of the rat has been investigated. This octapeptide decreases the active tension and abolished it completely at a concentration of 5×10−7g/ml. The effect is not caused by an adrenergic mechanism but by a direct action on the smooth muscle cell.

Reduced salivary oxytocin after an empathic induction task in Intimate Partner Violence perpetrators: Importance of socio-affective functions and its…

2022

Intimate Partner Violence (IPV) has been linked to difficulties in socio-affective functions. Nevertheless, the underlying psychobiological mechanisms that might be responsible for them remain unclear. Oxytocin (OXT) stands out as an important hormone that may favor the salience of social information, due to its relevance in empathy and prosocial behavior. Thus, the study of salivary OXT (sOXT) may provide further information about potential impairments in social cognition in IPV perpetrators. This study analyzed the effects of an empathic induction task, performed through negative emotion-eliciting videos, on endogenous sOXT levels, mood state, and emotional perception in 30 IPV perpetrato…