Search results for "P.H.S."

A genome-wide association study of marginal zone lymphoma shows association to the HLA region

2015

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10−15) and HLA-B (rs2922994, P=2.43 × 10−9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

Statistical atmospheric parameter retrieval largely benefits from spatial-spectral image compression

2021

The infrared atmospheric sounding interferometer (IASI) is flying on board of the Metop satellite series, which is part of the EUMETSAT Polar System. Products obtained from IASI data represent a significant improvement in the accuracy and quality of the measurements used for meteorological models. Notably, the IASI collects rich spectral information to derive temperature and moisture profiles, among other relevant trace gases, essential for atmospheric forecasts and for the understanding of weather. Here, we investigate the impact of near-lossless and lossy compression on IASI L1C data when statistical retrieval algorithms are later applied. We search for those compression ratios that yield…

Alzheimer: A Decade of Drug Design. Why Molecular Topology can be an Extra Edge?

2017

Background The last decade was characterized by a growing awareness about the severity of dementia in the field of age-related and no age-related diseases and about the importance to invest resources in the research of new, effective treatments. Among the dementias, Alzheimer's plays a substantial role because of its extremely high incidence and fatality. Several pharmacological strategies have been tried but still now, Alzheimer keeps being an untreatable disease. In literature, the number of QSAR related drug design attempts about new treatments for Alzheimer is huge, but only few results can be considered noteworthy. Providing a detailed analysis of the actual situation and reporting the…

Size- and Structure-Selective Noncovalent Recognition of Saccharides by Tetraethyl and Tetraphenyl Resorcinarenes in the Gas Phase

2008

The noncovalent complexation of tetraethyl and tetraphenyl resorcinarenes with mono-, di-, and oligosaccharides was studied with negative-polarization electrospray ionization quadrupole ion trap and electrospray ionization Fourier-transform ion cyclotron resonance mass-spectrometric analysis. The saccharides formed 1:1 complexes with deprotonated resorcinarenes, which exhibited clear size and structure selectivity in their complexation. In the case of the monosaccharides, hexoses formed much more abundant and kinetically stable complexes than pentoses or deoxyhexoses. A comparison of the mono-, di-, and oligosaccharides revealed that both the relative abundance and stability of the complexe…

Marxist Influences in Psychology

2020

Marxist ideas influenced and inspired psychological thinking and practice in the 20th century in a range of ways. In different parts of the world, unique versions of Marxist psychology emerged as answers to questions and problems raised by specific historical contexts. As shown in the early 21st century scholarly interventions in Lev Vygotsky studies, the Soviet psychologist’s work was deeply embedded in the sociopolitical, cultural, and ideological context of early Soviet Russia. In countries such as Brazil and Italy, Marxism had a more indirect influence as an emancipatory discourse. In the wider framework of Latin American liberatory ideas and struggles, the educational philosopher Paulo…

Is service climate strength beneficial or detrimental for service quality delivery?

2011

This study examines whether climate strength has a direct, moderating, or curvilinear effect in the relationship between service climate and customer service quality perceptions. To this end, we carried out cross-sectional and lagged empirical studies in the Spanish hospitality sector. Our cross-sectional results confirmed that high climate strength in managerial practices fosters a positive impact of managerial practices on customer service quality evaluations. However, other results related to customer orientation of services question the idea that service climate strength is always a precursor of service quality. High climate strength in customer orientation enhanced the negative relatio…

Genomic profiling to assess the clonal relationship between histologically distinct intracranial tumours

2012

Testing the stage-discharge relationship of a sharp crested sluice gate deduced by the momentum equation for a free-flow condition

2018

Abstract In this paper the stage-discharge relationship of a sharp crested sluice gate is deduced by applying the momentum equation for a free flow condition. The theoretically deduced stage-discharge formula was then calibrated using experimental flume data obtained in previous investigations carried out for a free-flow condition. The deduced stage–discharge relationship is characterized by a momentum coefficient which is empirically estimated by the ratio between the height of the orifice and the water depth in the section upstream the gate. The relative errors are always less than or equal to - 10% to +10% and 71.4% of the errors are less than or equal to ± 2%.

A Method Based on Amplitude Probability Density Representation for Sounding High Frequency Noise in Ionospheric Channels

2021

High Frequency (HF) communications efficiency require a precise characterization of the ionospheric channel’s noise. We present a rapid and accurate method to sound the HF ionospheric channels that enables tracing of the time-availability of the channel based on imposed electric field strength thresholds. The method makes use of the amplitude probability density implemented in a real-time spectrum analyzer. Sounding of 3, 10 and 20 kHz bandwidth channels in the 4.8 – 8.8 MHz range is exemplified and specific observations are presented.

On the influence of curvature and torsion on turbulence in helically coiled pipes

2014

Turbulent flow and heat transfer in helically coiled pipes at Ret=400 was investigated by DNS using finite volume grids with up to 2.36×10^7 nodes. Two curvatures (0.1 and 0.3) and two torsions (0 and 0.3) were considered. The flow was fully developed hydrodynamically and thermally. The central discretization scheme was adopted for diffusion and advection terms, and the second order backward Euler scheme for time advancement. The grid spacing in wall units was ~3 radially, 7.5 circumferentially and 20 axially. The time step was equal to one viscous wall unit and simulations were typically protracted for 8000 time steps, the last 4000 of which were used to compute statistics. The results sho…