Search results for "P11"
showing 10 items of 42 documents
HSP110 promotes colorectal cancer growth through STAT3 activation.
2017
IF 7.932; International audience; Heat shock protein 110 (HSP110) is induced by different stresses and, through its anti-apoptotic and chaperoning properties, helps cells survive these adverse situations. In colon cancers, HSP110 is abnormally abundant. We have recently shown that colorectal cancer patients with microsatellite instability (MSI) had an improved response to chemotherapy because they harbor an HSP110-inactivating mutation (HSP110DE9). In this work, we used patient biopsies, human colorectal cancer cells grown in vitro and in vivo (xenografts), and intestinal crypts to demonstrate that HSP110 is also involved in colon cancer growth. We showed that HSP110 induces colon cancer ce…
HSP110 : role in colorectal cancer development and immunogenicity
2015
Our team studies HSPs, including HSP110. HSPs are chaperones involved in the folding of newly synthesized and denatured proteins. HSPs are overexpressed under stress conditions and are involved in cell survival thanks to their anti-apoptotic and anti-aggregation functions. HSP110 is overexpressed in colorectal cancer and is associated with a poor prognosis. The expression of a mutant HSP110, named HSP110DE9, has been shown in MSI colorectal cancer. This one was shown to act there as a dominant negative, by binding HSP110 and inhibiting its functions. Its expression sensitizes cancer cells to chemotherapy and is associated with a better prognosis for patients.I was first interested in HSP110…
Thanatos associated protein 11 (THAP11) modulates expression of c-MYC by binding the HB2.8 enhancer blocker element.
2014
16P11.2 microdeletion/microduplication syndrome: Further characterization of a critical region for neuropsychiatric development
2013
Diagnosi precoce di disabilità intellettiva sindromica
2015
delezione 17p11.2, Sindrome di Smith-Magenis, anomalie congenite multiple
Physical oceanography, sea-bed photographs and videos of benthos from the Weddell Sea taken with remote operated vehicle CHEROKEE during POLARSTERN c…
2010
The marine ecosystem on the eastern shelf of the Antarctic Peninsula was surveyed 5 and 12 years after the climate-induced collapse of the Larsen A and B ice shelves. An impoverished benthic fauna was discovered, that included deep-sea species presumed to be remnants from ice-covered conditions. The current structure of various ecosystem components appears to result from extremely different response rates to the change from an oligotrophic sub-ice-shelf ecosystem to a productive shelf ecosystem. Meiobenthic communities remained impoverished only inside the embayments. On local scales, macro- and mega-epibenthic diversity was generally low, with pioneer species and typical Antarctic megabent…
Onko osaamisella sukupuoli?
2001
Työn sukupuolen mukainen jako vallitsee kaikkien Euroopan maiden työ- ja koulutusmarkkinoita. Ammatillista osaamista ja sukupuolta koskevat käytännölliset ja tieteelliset keskustelut kohtaavat kuitenkin harvoin. Artikkeli kuvaa kansainvälistä tutkimusta, jossa selvitetään osaamisen sukupuolittumista ja sen ylittämisen mahdollisuuksia työpaikkojen ja oppilaitosten kasvatuskäytännöissä. Suomalaisten tutkimushaastattelujen alustavassa luennassa niin miehet kuin naiset pitävät osaamisia sukupuolettomina. Syvempi tulkinta edellyttää osaamis- ja gender-diskurssien kriittistä hyödyntämistä.
The deubiquitinase USP11 is a versatile and conserved regulator of autophagy
2021
Autophagy is a major cellular quality control system responsible for the degradation of proteins and organelles in response to stress and damage to maintain homeostasis. Ubiquitination of autophagy-related proteins or regulatory components is important for the precise control of autophagy pathways. Here, we show that the deubiquitinase ubiquitin-specific protease 11 (USP11) restricts autophagy and that KO of USP11 in mammalian cells results in elevated autophagic flux. We also demonstrate that depletion of the USP11 homolog H34C03.2 in Caenorhabditis elegans triggers hyperactivation of autophagy and protects the animals against human amyloid-β peptide 42 aggregation-induced paralysis. USP11…
MANAGEMENT CHALLENGES - A PREVIEW IN FUTURE OF CAPITALISM
2012
The economic crisis comes in the context the deepest political crisis faced by the EU today. Economic catastrophe led to the strongest economic crisis since the '30s. Downturns were commonly explained using technical arguments, economic or financial reasons. Because they were discussed by experts in language often inaccessible, so often we face today and dangerous misunderstanding of the population crisis. When talking about economic crises tend to forget that they come in a political context, social and cultural. At the same time, how society reacts to the crisis is decisively influenced by the values it embraces.
Ideas, conceptos y dilemas para la implementación de una plataforma nacional de ODR en materia de consumo en Chile desde la perspectiva UE
2019
En la presente tesis hemos desarrollado una extensiva investigación monográfica en busca del concepto de ODR (online dispute resolution), el cual se encuentra en un constante desarrollo en el quehacer jurídico procesal comparado, sobre todo en materia del derecho de consumidor en el espacio de integración de la Unión Europea, con el impulso otorgado a la materia por la directiva 2011/2013 EU y el Reglamento 534/2013 EU,y la consecuente transposición de dichas normas a las tradiciones jurídicas de los Estados miembros. La búsqueda para generar un marco jurídico cada vez más proclive al consumidor dentro del mercado único europeo, ha impulsado el desarrollo de la legislación comunitaria, y la…