Search results for "P3"

Increased regulatory T-cell frequencies in patients with advanced melanoma correlate with a generally impaired T-cell responsiveness and are restored…

2009

Naturally occurring CD4(+) CD25(+) regulatory T-cell (Treg) activity is assumed to facilitate tumor development and progression. To elucidate the possible role of Tregs in the course of melanoma progression, we analysed the frequency of Tregs in the peripheral blood of patients at melanoma stages I-IV and in patients at melanoma stage IV that underwent dendritic cell (DC)-based immunotherapy. Using CD25, Foxp3, CD127 and HLA-DR as Treg associated markers, we observed increased Treg frequencies in patients at the late melanoma stage (stage IV) when compared to healthy donors. Accumulation of Tregs in patients with progressed melanoma correlated with a general reduction of T-cell responsivene…

Root-induced decomposer growth and plant N uptake are not positively associated among a set of grassland plants

2007

Abstract It is known that plant species can induce development of different soil decomposer communities and that they differ in their influence on organic matter decomposition and N mineralization in soil. However, no study has so far assessed whether these two observations are related to each other. Based on the hypothesis that root-induced growth of soil decomposers leads to accelerated decomposition of SOM and increased plant N availability in soil, we predicted that (1) among a set of grassland plants the abundance of soil decomposers in the plant rhizosphere is positively associated with plant N uptake from soil organic matter. To test this, we established grassland microcosms consisti…

Cicatrici: El secreto de sus ojos di Sacheri e Campanella

2012

In 2005 the Argentinian writer Eduardo Sacheri published The Question in Their Eyes (La pregunta de sus ojos).  The novel narrates on a double level, both fictional and temporal, the decision of a retired prosecutor to come to terms with a case of rape and murder which had taken place years earlier: his life had been shattered by the consequences of that tragedy, and writing about it would be a way to start living again.  The director Juan José Campanella - widely famous for having directed episodes of the television series Law & Order, but especially as the director of successful films such as El hijo de la novia - decided to adapt the novel and involved Sacheri in the project: the close c…

"Non è in crisi il romanzo borghese": una polemica degli anni Sessanta

2018

26 marzo 1965: su «Paese Sera-Libri» esce la trascrizione, mai più riedita, di una delle svariate tavole rotonde organizzate dal giornale in quegli anni, intitolata Requiem per il romanzo?: a cui hanno partecipato Alberto Arbasino, Francesco Leonetti, Alberto Moravia, Pier Paolo Pasolini, Edoardo Sanguineti, e, in veste di coordinatore, Armando Vitelli (fondatore e curatore del supplemento, con Piero Dallamano). La ripubblichiamo qui, insieme ad altri due pezzi di poco successivi, rispettivamente di Italo Calvino e di Vitelli stesso, che come vedremo le si agganciano.

Different profile and distribution of antigen specific T cells induced by intranasal and intrarectal immunization with rotavirus 2/6-VLP with and wit…

2013

International audience; In this study, we compared both the profile and distribution of antigen specific primed T cells after intrarectal (IR) and intranasal (IN) immunization with rotavirus (RV) 2/6-VLP, alone or in the presence of LT-R192G, in order to highlight the differences between the two routes and the impact of the adjuvant. Adult BALB/c mice were immunized once with 2/6-VLP with or without adjuvant and the T cell response was analyzed in lymphoid tissues after in vitro restimulation with the antigen. IN, but not IR, immunization of mice with 2/6-VLP alone induced antigen-specific IL-10 and IL-17 secreting T cells. IL-10-, in contrast to IL-17-, secreting T cells did not migrate to…

Rubinstein-Taybi syndrome (CREBBP, EP300)

2011

1.2 OMIM# of the disease180849.1.3 Name of the analyzed genes or DNA/chromosome segmentsCREBBP, EP300 (E1A binding protein p300).1.4 OMIM# of the genes600140 (CREBBP), 602700 (EP300).1.5 Mutational spectrumMainly frameshift, nonsense, splice site and missense mutations. Lessfrequently large deletions (one or more exons) and rarely balancedinversions and translocations. Mutations are heterozygous, and mosaicmutations have been described. At present, more than 100 pathogenicmutations are known for the two genes together, but mutations inEP300 are much less common (only 11 so far).

Tissue-specific mosaicism in a patient with Rubinstein–Taybi syndrome and CREBBP exon 1 duplication

2019

Protein kinase CK2 governs the molecular decision between encephalitogenic T H 17 cell and T reg cell development

2016

T helper 17 (TH17) cells represent a discrete TH cell subset instrumental in the immune response to extracellular bacteria and fungi. However, TH17 cells are considered to be detrimentally involved in autoimmune diseases like multiple sclerosis (MS). In contrast to TH17 cells, regulatory T (Treg) cells were shown to be pivotal in the maintenance of peripheral tolerance. Thus, the balance between Treg cells and TH17 cells determines the severity of a TH17 cell-driven disease and therefore is a promising target for treating autoimmune diseases. However, the molecular mechanisms controlling this balance are still unclear. Here, we report that pharmacological inhibition as well as genetic ablat…

Decreased SAPK/JNK signalling affects cytokine release and STAT3 activation in psoriatic fibroblasts.

2015

Inhibition of VEGF expression through blockade of Hif1a and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer c…

2013

Background: Hepatocellular carcinoma (HCC) growth relies on angiogenesis via vascular endothelial growth factor (VEGF) release. Hypoxia within tumour environment leads to intracellular stabilisation of hypoxia inducible factor 1 alpha (Hif1α) and signal transducer and activator of transcription (STAT3). Melatonin induces apoptosis in HCC, and shows anti-angiogenic features in several tumours. In this study, we used human HepG2 liver cancer cells as an in vitro model to investigate the anti-angiogenic effects of melatonin. Methods: HepG2 cells were treated with melatonin under normoxic or CoCl2-induced hypoxia. Gene expression was analysed by RT–qPCR and western blot. Melatonin-induced anti-…