Search results for "P3"
showing 10 items of 786 documents
SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus.
2006
Histone acetylation plays a key role in the regulation of gene expression. The chromatin structure and accessibility of genes to transcription factors is regulated by enzymes that acetylate and deacetylate histones. The Sin3A corepressor complex recruits histone deacetylases and in many cases represses transcription. Here, we report that SAP30L, a close homolog of Sin3-associated protein 30 (SAP30), interacts with several components of the Sin3A corepressor complex. We show that it binds to the PAH3/HID (Paired Amphipathic Helix 3/Histone deacetylase Interacting Domain) region of mouse Sin3A with residues 120–140 in the C-terminal part of the protein. We provide evidence that SAP30L induces…
Neurophysiological markers of subjective memory complaints in healthy people
2022
Con el envejecimiento de la población es importante comprender los cambios neurofisiológicos que se producen. En este contexto, las quejas subjetivas de la memoria (QSM) se están convirtiendo en un tema de interés ya que se han considerado un factor de riesgo para desarrollar trastornos relacionados con demencias como el deterioro cognitivo leve y enfermedad de Alzheimer. Por lo tanto, es importante investigar los biomarcadores tempranos para la detección y la planificación de los tratamientos. En este sentido, el procesamiento de emociones faciales es una importante función cognitiva comúnmente afectada en personas con trastornos relacionados con demencias que podría ayudar a analizar camb…
Impacto de la farmacogenética en la inmunosupresión con Tacrólimus en el trasplante hepático y renal
2017
Los trasplantes de órganos sólidos, en especial el trasplante hepático y renal, han permitido aumentar la supervivencia de la población, lo que se ha potenciado con el desarrollo de las técnicas quirúrgicas y de la inmunosupresión farmacológica, dentro de los que destaca la aparición de los inhibidores de la calcineurina (InC), especialmente tacrólimus. A pesar de estos avances, persisten cifras importantes de rechazo agudo y de toxicidad aguda y crónica precisamente por el uso de los InC que pueden dificultar la mejoría de la supervivencia y la calidad de vida de los pacientes trasplantados. Para reducir estos riesgos se han implementado intervenciones para mejorar la dosificación de los I…
Emotional modulation of the attentional blink and the relation to interpersonal reactivity
2013
The extent of the attentional blink effect on detection rates in rapid serial visual presentations is modulated by the emotionality of the stimuli. Emotionally salient stimuli are detected more often, even if presented in the attentional blink period, and elicit an enlarged P3 response, which has been interpreted as enhanced consolidation. This effect correlates with individual differences in trait affectivity such as anxiety or dysphoria. Here, we ask if it is also related to the capacity to detect emotions in others, i.e., to interpersonal social traits. We therefore presented emotional and neutral images depicting social scenes as targets in an attentional blink design and measured detec…
Polymorphism of Amyloid Fibrils and their Complexes with Catalase
2014
Catalase binding to amyloid fibrils has been shown for the Alzheimer’s amyloid-β (Aβ), type 2 diabetes-associated islet amyloid polypeptide (IAPP) and Creutzfeldt-Jakob disease-associated prion protein (PrP). Catalase targets a specific domain with a GAII-like sequence and there are a number of other amyloid fibril-forming proteins that contain related sequences, such as the Parkinson’s associated α-synuclein protein and the Huntington disease protein Huntingtin. Using transmission electron microscopy (TEM) analysis, interactions show specific binding of catalase to some, but not all, fibrillar forms of Aβ, IAPP and PrP fragments, allowing determination of the fibrillar forms that contain a…
HPLC Determination of Polyphenols from Calendula officinalis L. Flowers
2017
Abstract Romanian spontaneous flora provides a lot of resources for the determination of different chemical compounds. This study uses flower samples from Calendula officinalis L. extracted through maceration. The chemical compounds determined were: (+)-catechin, caffeic acid, chlorogenic acid, cinnamic acid, ferulic acid, gallic acid, rutin, resveratrol and quercetin. They were analyzed by using an optimized HPLC method. (+)-Catechin, caffeic acid, chlorogenic acid and quercetin could not be identified in the analyzed samples. The greatest amount of phenolic compound found was rutin and the smallest quantity was determined for ferulic acid. The quantified compounds have proven to have bene…
Neurocognitive Markers During Prolonged Breath-Holding in Freedivers: An Event-Related EEG Study
2019
Since little is known concerning the psychological, cognitive, and neurophysiological factors that are involved in and important for phases of prolonged breath-holding (pBH) in freedivers, the present study uses electroencephalography (EEG) to investigate event-related neurocognitive markers during pBH of experienced freedivers that regularly train pBH. The purpose was to determine whether the well-known neurophysiological modulations elicited by hypoxic and hypercapnic conditions can also be detected during pBH induced hypoxic hypercapnia. Ten experienced free-divers (all male, aged 35.10 ± 7.89 years) were asked to hold their breath twice for 4 min per instance. During the first pBH, a ch…
L'interprete al cinema: stereotipi, pregiudizi e realtà
2020
The figure of the interpreter in history has always oscillated between visibility and invisibility. Although today there is a tendency to give it increasing recognition, some categories (cultural mediators, war and sign interpreters) still remain in a poorly recognized situation and often operate in precarious working conditions. The interpreter as a subject of study has been present in world literature for years. We will investigate what has become the interpreter as a subject in world cinema. What is the semiotic process for which a given image of the interpreter communicates a certain cliché or suggests certain characteristics that the director (or the screenwriter) wanted to highlight. …
PET Imaging of the Impact of Extracellular pH and MAP Kinases on the p-Glycoprotein (Pgp) Activity
2012
The functional activity of p-glycoprotein (Pgp) can be increased in vitro by an extracellular acidosis via activation of MAP kinases (p38, ERK1/2). In order to study these effects in vivo a new (68)Ga-labeled PET tracer was developed which serves as a substrate of the Pgp and therefore indirectly mirrors the Pgp activity. For in vivo studies, experimental tumors were imaged under acidic conditions (inspiratory hypoxia, injection of lactic acid) and during inhibition of MAP kinases in a μ-PET system. In vitro, [(68)Ga]MFL6.MZ showed an accumulation within the cells of about 20% which was increased to 30% by Pgp inhibition. In solid tumors a marked tracer uptake was observed showing spatial h…
THE IMPACT OF THE FUTURE COMMUNITARIAN BUDGET ON THE COMMON AGRICULTURAL POLICY
2013
The main purpose of the Common Agricultural Policy was oriented towards production, within a short time span, due to massive subsidies from 2/3 of the communitarian budget. At this time the main objective of the Common Agricultural Policy is to reach quality, ecologic and food safety parameters, for which only 1/3 of the communitarian budget is allocated. The Common Agricultural Policy is supported by members with developed agricultural sectors, but also by states in Central and Eastern Europe, which have difficulties in this sector. The communitarian budget subsidizes the two main pillars of agriculture: "direct payments" and "rural development".