Search results for "P3"
showing 10 items of 786 documents
On the social meanings inherent in literacy campaigns
1990
Artikkelissa tarkastellaan luku- ja kirjoitustaitokampanjoita käsittelevän kansainvälisen dokumenttiaineiston perusteella sitä, millaisia merkityksiä sisältyy lukuja kirjoitustaidottomuuden määrittelyyn yhteiskunnalliseksi ongelmaksi, ja asetetaan kyseenalaiseksi tässä aineistossa ilmenevä yleismaailmallinen ideologia. Lisäksi pohditaan luku- ja kirjoitustaidon mahdollisista emansipatorista merkitystä kehitysmaiden oloissa.
The interpreter’s footing in Spanish-Italian medical interviews
2014
El artículo analiza unos fragmentos de un corpus de diez entrevistas médicas, grabadas entre abril y julio de 2009 en el Instituto Valenciano de Infertilidad de Barcelona, caracterizadas por la presencia de un médico de habla española, uno o dos pacientes italianos y una intérprete. Se examina cómo cambia la alineación verbal de esta última, dependiendo de las diferentes situaciones comunicativas que tiene que afrontar. Para lograr este objetivo, se hace hincapié en los estudios de Goffman sobre el footing (o pie) (1981: 325-326), a los de Wadensjö (1998: 91-92) y de Merlini y Favaron (2007: 116-117). Se demuestra que la intérprete no sólo traduce lo que dicen los interlocutores primarios, …
Editorial: Breakthrough BCI Applications in Medicine
2020
Extract Mismatch Negativity and P3a through Two-Dimensional Nonnegative Decomposition on Time-Frequency Represented Event-Related Potentials
2010
This study compares the row-wise unfolding nonnegative tensor factorization (NTF) and the standard nonnegative matrix factorization (NMF) in extracting time-frequency represented event-related potentials—mismatch negativity (MMN) and P3a from EEG under the two-dimensional decomposition The criterion to judge performance of NMF and NTF is based on psychology knowledge of MMN and P3a MMN is elicited by an oddball paradigm and may be proportionally modulated by the attention So, participants are usually instructed to ignore the stimuli However the deviant stimulus inevitably attracts some attention of the participant towards the stimuli Thus, P3a often follows MMN As a result, if P3a was large…
Amphiregulin activates human hepatic stellate cells and is upregulated in non alcoholic steatohepatitis
2015
AbstractAmphiregulin (AR) involvement in liver fibrogenesis and hepatic stellate cells (HSC) regulation is under study. Non-alcoholic fatty liver disease (NAFLD) and its more severe form non-alcoholic steatohepatitis (NASH) may progress to cirrhosis and hepatocellular cancer (HCC). Our aim was to investigate ex vivo the effect of AR on human primary HSC (hHSC) and verify in vivo the relevance of AR in NAFLD fibrogenesis. hHSC isolated from healthy liver segments were analyzed for expression of AR and its activator, TNF-α converting enzyme (TACE). AR induction of hHSC proliferation and matrix production was estimated in the presence of antagonists. AR involvement in fibrogenesis was also ass…
Severe Tremor After Cotrimoxazole-Induced Elevation of Venlafaxine Serum Concentrations in a Patient With Major Depressive Disorder
2013
: We describe a female patient who was an extensive metabolizer of cytochrome P450 isoenzyme (CYP) 2D6 and an intermediate metabolizer of CYP2C19 (genotype: CYP2C19 *1/*2). She exhibited high serum concentrations of venlafaxine and O-desmethylvenlafaxine and developed severe tremor after comedication with cotrimoxazole (sulfamethazole/trimethoprim). Venlafaxine is mainly metabolized by O- and N-demethylation. O-demethylation is catalyzed by the highly polymorphic CYP2D6 and N-demethylation by several enzymes, CYP2C19, CYP2C9, and CYP3A4. The observed overall pharmacokinetic effect was most probably the result of decreased N-demethylation of venlafaxine by (1) reduced expression of CYP2C19 d…
Effects of steatosis on drug-metabolizing capability of primary human hepatocytes.
2007
Abstract The suitability of liver grafts discarded for transplantation because of macrosteatosis for preparing human hepatocyte cultures for in vitro drug metabolism studies has been examined. Lower cell viability and yield of isolation procedure were obtained from fatty livers (>40% steatosis) with respect to normal tissue. Significant reductions in 7-ethoxycoumarin O-deethylation (ECOD) and testosterone oxidations were found in hepatocytes prepared from steatotic livers. The potential impact of lipid accumulation on P450 enzymes was studied in vitro by incubation of cultured hepatocytes with long chain free fatty acids (FFA). Treatment of cells with 0.25–3 mM FFA induced dose-dependent ac…
Dual specificity phosphatase 1 knockout mice show enhanced susceptibility to anaphylaxis but are sensitive to glucocorticoids.
2007
Dual specificity phosphatase DUSP1 (otherwise known as mitogen-activated phosphatase 1 or MKP-1) dephosphorylates MAPKs, particularly p38, and negatively regulates innate immunity. Recent studies have shown that the DUSP1 gene is transcriptionally up-regulated by glucocorticoids (GCs) and that the antiinflammatory action of GCs is impaired in DUSP1-/- mice. Here we show that GC-mediated dephosphorylation of ERK-1 and ERK-2 activated by IgE receptor cross-linking is unimpaired in bone marrow-derived mast cells (BMMCs) of DUSP1-/- mice. Dephosphorylation of phospho-p38 MAPK is impaired but only at early times of GC treatment. Proinflammatory cytokine and chemokine gene expression (CCL2, IL-6,…
NF-ĸB as node for signal amplification during weaning.
2011
Post-lactational involution has been reported to share common features with breast tumor development. A deep characterization of the signaling triggered after weaning would help to unveil the complex relationship between involution and breast cancer. NF-κB, a crucial factor in the involuting gland, might be an important regulatory node for signal amplification after weaning; however there is limited information about the identity of NF-κB-target genes and the molecular mechanisms leading to the selection of genes involved in a particular biological process. We identified 4532 target genes in mammary gland at 48h weaning, by genome-wide analysis of regions bound by RelA(p65)-NF-κB in vivo. I…
Distinct subsets of regulatory T cells during pregnancy: is the imbalance of these subsets involved in the pathogenesis of preeclampsia?
2008
Abstract Regulatory T cells (CD4 + CD25 + FoxP3 + -Treg cells) are important regulators of tolerance induction during pregnancy. We now found that the number of CD4 + CD25 + FoxP3 + -Treg cells decreases during normal course of pregnancy and even more so in women affected by preeclampsia. The functional activity of these CD4 + CD25 + -Treg cells was significantly reduced in comparison to those of healthy pregnants. Further analysis revealed two Treg subsets that differed with regard to the FoxP3 and CD25 expression. The percentage of both, CD4 + CD25 + FoxP3 high+ -Treg and CD4 + CD25 high+ FoxP3 + , was maximal in the first and second trimenon, but declined severely in the third trimenon. …