Search results for "PAB"
showing 10 items of 372 documents
Con "d" de "dual": investigación sobre la implantación del sistema dual en la formación profesional en España
2017
En el presente artículo, exponemos los principales resultados de la investigación que hemos llevado a cabo sobre el proceso de implantación de la formación profesional dual en la totalidad de los ciclos de dicha etapa en España, al amparo de un proyecto europeo de transferencia de innovación. La metodología utilizada es la cuantitativa. Se realizaron y se validaron dos cuestionarios dirigidos a la dirección y al profesorado tutor de formación profesional dual en un universo de 456 centros que desarrollaban esta modalidad en España en 2015. Las encuestas fueron respondidas por un total de 179 centros de formación profesional pertenecientes a 16 comunidades autónomas. De estos centros, 136 co…
NF-κB Inhibition Restores Sensitivity to Fas-Mediated Apoptosis in Lymphoma Cell Lines
2003
Failure to perform the Fas-related apoptosis pathway can account for tumor resistance both to chemotherapeutic agents and to immunological effectors. We studied the role of NK-kappaB in Fas-resistance, employing the Fas-sensitive human T-lymphoma HuT78 cell line and its Fas-resistant variants HuT78B1 and HuT78G9. All these cell lines expressed high levels of constitutively activated NF-kappaB. Pretreatment of cells with NF-kappaB inhibitors (PDTC, MG132, or SN50) strongly enhanced CH11-induced apoptosis in HuT78 and Hut78G9 cells, while only MG132 showed a similar potentiating effect in HuT78B1. The described synergism was significantly inhibited by pretreatment with the anti-Fas-blocking a…
A TR-FRET based functional assay for screening activators of CARM1
2013
Epigenome is an emerging field that demands selective cell-permeable chemical probes to perturb, especially in vivo, the activity of specific enzymes involved in modulating the epigenetic codes. Coactivator Associated Arginine (R) Methyltransferase 1 (CARM1) is a coactivator of estrogen receptor α (ERα), the main target in human breast cancer. We previously showed that overexpression of CARM1 by two-fold in MCF7 breast cancer cells increased the expression of ERα-target genes involved in differentiation and reduced cell proliferation, leading to the hypothesis that activating CARM1 by chemical activators may be therapeutically effective in breast cancer. Selective, potent, cell-permeable CA…
Amministrazione performante e sistema dei controlli interni
2023
Since the origins of post-unitary reform processes, analyses, and reconstructions aimed at deepening the needs and development paths for maximizing the functioning of the italian administration have directly or indirectly included the legal institutions of administrative control. Controls have progressively become an essential thematic axis in the characterization of the fundamental contents of the formation of the administrative state and the 'administrative question' of conformity in public organization and administrative activity to the principle of legality. They are seen as a specific legal institution, in which it is possible to interpret both the evolution of the state organization a…
Uso secuencial de herramientas de control de calidad en procesos productivos: una aplicación en el sector agroalimentario = Sequential use of quality…
2014
<p>Las diferentes herramientas del Control Estadístico de Calidad proporcionan mejores resultados si su uso se lleva a cabo de manera secuencial, facilitando la detección de los puntos débiles del proceso productivo. Así, en el presente estudio se expone un método de trabajo en el que se utilizan, atendiendo a la necesidad en cada punto de la cadena de producción, algunas de dichas herramientas. Concretamente se propone el uso del diagrama de flujo, gráfico de Pareto, hojas de comprobación, gráficos de control (en este caso gráfico p y gráfico de media-recorrido), así como el análisis de la varianza (ANOVA). El procedimiento se aplica a una empresa del sector agroalimentario, interesa…
Quality System for Production Software as Tool for Monitoring and Improving Organization KPIs
2013
In this paper we propose a solution as support for quality systems for production software. The motivation behind this study was to reduce that cost in the production area caused by gaps in the quality of the production software. Our proposal: QSPS (Quality System for Production Software) is offering support in the "vulnerable points" of these quality systems which usually generate nonconformities and have proved to be difficult or impossible to control. QSPS is a method in seven steps or modules that integrates also software tools, templates, checklists, evaluating tools elaborated complying to products, process and system quality standards. If other analyzed methods like: Scrum, XP, Fuzzy…
Capability studies, helpful tools in process quality improvement
2017
Ability of processes to meet customer’quality requirements has become essential for providing competitive advantages such as cost savings, reducing the number of nonconfoming products or increasing customer satisfaction. This paper aims to conduct a capability study for a swaging process (that ensures an assembly dimension) of a key product characteristic (the outer diameter of a new part), related to the concept of capability and performance indices and how these metrics can be used and interpreted to become powerful tools for decision making. To achieve the goal of the paper, the following key aspects were analyzed: capability of the measurement system capability (gage R&R), production eq…
An AMI System for User Daily Routine Recognition and Prediction
2014
Ambient Intelligence (AmI) defines a scenario involving people living in a smart environment enriched by pervasive sensory devices with the goal of assisting them in a proactive way to satisfy their needs. In a home scenario, an AmI system controls the environment according to a user’s lifestyle and daily routine. To achieve this goal, one fundamental task is to recognize the user’s activities in order to generate his daily activities profile. In this chapter, we present a simple AMI system for a home scenario to recognize and predict users’ activities. With this predictive capability, it is possible to anticipate their actions and improve their quality of life. Our approach uses a Hidden M…
Biopartitioning micellar chromatoraphy to predict blood to lung, blood to liver, blood to fat and blood to skin partition coefficients of drugs
2009
[EN] Biopartitioning micellar chromatography (BMC), a mode of micellar liquid chromatography that uses micellar mobile phases of Brij35 in adequate experimental conditions, has demonstrated to be useful in mimicking the drug partitioning process into biological systems. In this paper, the usefulness of BMC for predicting the partition coefficients from blood to lung, blood to liver. blood to fat and blood to skin is demonstrated. PLS2 and multiple linear regression (MLR) models based on BMC retention data are proposed and compared with other ones reported in bibliography. The proposed models present better or similar descriptive and predictive capability. (C) 2008 Elsevier B.V. All rights r…
Psychometric properties of the measure of achieved capabilities in homeless services
2023
Abstract Background Purposeful participation in personally meaningful life tasks, enjoyment of positive reciprocal relationships, and opportunities to realize one’s potential are growth-related aspects of a meaningful life that should be considered important dimensions of recovery from homelessness. The extent to which homeless services support individuals to achieve the capabilities they need to become who they want to be and do what they want to do is, in turn, an important indicator of their effectiveness. In this study, we developed a measure of achieved capabilities (MACHS) for use in homeless services settings, and assessed its construct and concurrent validity. Methods We analysed da…