Search results for "PAB"
showing 10 items of 372 documents
Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants.
1998
Although nitric oxide (NO) and antioxidants inhibit adhesion molecule expression, their inhibitory effects on nuclear factor kappaB (NF-kappaB) activation may differ. The NO donors, but not 8-bromo-cGMP, decreased tumor necrosis factor alpha (TNF-alpha)-induced VCAM-1, ICAM-1, and E-selectin expression by 11-70%. In contrast, NAC completely abolished VCAM-1 and E-selectin expression and decreased ICAM-1 expression by 56%. Gel shift assays demonstrate that NF-kappaB activation was inhibited by both NO and antioxidants. The activation of NF-kappaB involves the phosphorylation and degradation of its cytoplasmic inhibitor IkappaB-alpha by 26S proteasomes. The 26S proteasome inhibitor MG132 prev…
DSC: software tool for simulation-based design of control strategies applied to wastewater treatment plants.
2011
This paper presents a computer tool called DSC (Simulation based Controllers Design) that enables an easy design of control systems and strategies applied to wastewater treatment plants. Although the control systems are developed and evaluated by simulation, this tool aims to facilitate the direct implementation of the designed control system to the PC of the full-scale WWTP (wastewater treatment plants). The designed control system can be programmed in a dedicated control application and can be connected to either the simulation software or the SCADA of the plant. To this end, the developed DSC incorporates an OPC server (OLE for process control) which facilitates an open-standard communic…
Central Bursting Defects in Drawing and Extrusion: Numerical and Ultrasonic Evaluation
1993
Abstract A new approach for the prediction of central bursting defects in extrusion and drawing is proposed: a finite element analysis of the processes has been carried out, and the obtained results have been elaborated by means of a post-processor, which, employing a proper ductile fracture criterion, is able to suggest if and where the central burst occur. An ultrasonic control system able to detect the insurgence of defects with a resolution of 0.2 mm. has been setup in order to verify the predictive capability of the model. The experimental results show a good agreement with the numerical predictions confirming the effectiveness of the proposed approach, whose industrial application app…
The New Nino Capability Index for Dynamic Process Capability Analysis
2013
The process capability analysis is a crucial activity to evaluate if the process outcome meets the design specifications. Classically, such analysis is performed by verifying the in-control condition of the process and evaluating suitable capability indices, by assuming the process in-control steady-state condition. However, the in-control period of the process characterizes only a part of the system functioning cycle, the one with the lower defective rate. In particular, the system functioning cycle is also characterized by the out-of-control period, during which a greater defective rate is produced, and such increasing is not considered by the widely adopted capability indices. As consequ…
The Role of Different Approaches in Inspection Process Improvement
2009
There is a need to better understand improvement of software inspection practices. Typically process improvement is driven by different reference models like CMMI. In the previous work we found that such model based approach alone didn’t provide sufficient support for inspection process improvement. This paper outlines an overall picture of inspection process improvement and four different approaches for it. These approaches are seen as complementary and the focus of the paper is on describing their role in the improvement process.
Team collaboration capabilities as a factor in startup success
2018
[EN] This paper discusses the role of team collaboration as a building block for cultivating capabilities in technology-based startups. This conceptual framework draws on a literature review of innovation and entrepreneurship research to understand the intra-organization collaboration mechanisms among team members in technology-based startups. Introducing the concept of team collaboration capabilities represents a new approach to understanding the interaction conditions that give rise to new capabilities from a venture team as its organizational base. Rapid new capability building represents a competitive advantage in environments characterized by innovative technological change, known as d…
Sustainable Entrepreneurial Orientation: A Business Strategic Approach for Sustainable Development
2017
This paper proposes sustainable entrepreneurial orientation (SEO) as a multidimensional construct that offers researchers the possibility of empirically testing their theoretical proposals in the sustainable entrepreneurship field. The authors propose an integration of different theories. In accordance with the dynamic capabilities view, SEO is approached under an organizational paradigm of strategic orientations delimited by competitive culture and multiple orientation perspectives. Furthermore, SEO's nature is conceived at a firm-based entrepreneurship level and is based on an integrated triple bottom line sustainability. This approach is conceptualized using a categorization scheme and d…
Innovativeness and Family-Firm Performance: The Moderating Effect of Family Commitment
2016
The positive relationship between innovativeness and firm performance is well established and applies equally to all businesses, including family firms. However, little is yet known about how the unique characteristics of family firms influence this relationship. Drawing upon the resource-based view (RBV) of the firm, this study explains how the interplay between innovativeness as a firm-specific resource and family commitment as a family-specific resource affects performance. The analysis of longitudinal survey data collected from Finnish family firms demonstrates a curvilinear (U-shaped) moderating effect of the owner family’s commitment to the firm, in that the impact of innovativeness o…
The Berkeley Innovation Index: A Quantitative Approach to Measure, Track and Forecast Innovation Capability Within Individuals and Organizations
2018
Innovation and entrepreneurship are essential processes for human development, market growth, and technological breakthroughs, and it is vital for economic growth. Despite its importance, innovation is inherently difficult to measure and hence it is almost impossible for an individual or organization to know how they can improve their innovation output or claim that they are great at innovation. This paper presents a novel approach to measure and quantify innovation, called the Berkeley Innovation Index (BII). The BII characterizes and measures innovation capability of an individual or an organization. It builds on the hypothesis that innovation performance depends on the people, culture, a…
Origen y progresso de las pabordrias de la Sancta Metropolitana Iglesia de Valencia / por Silvio Cipres de Pobar ...
1641
Esc. xil. de València a port i en p. 6 Sign.: A-P4